Actinobacillus actinomycetemcomitans is a gram negative facultative anaerobe for which a complete genomic sequence is herein generously made available in advance of publication by David Dyer, Bruce Roe and colleagues at the University of Oklahoma. Their work on this genome was funded by NIDCR at the NIH. Strain HK1651 was employed for the sequencing project. For questions regarding the sequencing and the strain, contact David Dyer. A.actinomycetemcomitans is a typical cause of periodontitis but it may also be associated with systemic infections and it has been of current interest in relation to arterial plaques.

More than 3000 orfs are encoded in the 2.1 Mb circular chromosome. Approximately 35 orfs predicted by the LANL Oralgen project but not by Oklahoma University are included. Thus the core information in this database is a table of 3000 + annotated records. Each gene record is identified by a gene ID, AA00001 - AA03016; be forewarned that record designations have some discontinuities and some IDs utilize the number suffix 1. Basic summaries of specific information are available below in the Predefined Database Searches that contain links to the particular gene record. Specialized analysis sections of the database are available below in the Specialized Analysis section.

Browsing and searching are also facilitated by the 'Functional Classes', 'EC Table', and 'Biochemical Pathways' summaries. For precise inquiries on the other hand, start with the search capabilities and their associated tables. We invite anyone with questions or suggestions to contact us ( brettin@lanl.gov).

Seventy-seven references covering the years 2002-2004 and drawn from the molecular subset of Medline are included; please let us know of any pertinent reference that may have been omitted.

A plasmid sequence, pVT745, has been reported in association with A. actinomycetemcomitans and is included in this database. This plasmid sequence of approximately 5.5 kb encodes 13 orfs , some of which are orthologous to chromosomal genes. For further information about the plasmid, see Galli,D.M et al. J. Bacteriol. 183 (5), 1585-1594 (2001), PMID: 11160089; Chen J et al., J Bacteriol. 2002 Nov;184(21):5926-34 PMID: 12374826; Novak KF et al, Microbiology. 2001 Nov;147(Pt 11):3027-35, PMID: 11700353 .

User Defined Database Searches
Basic Search
Intermediate Search
Sequence Search
Protein Motif Search
Repeat Search

Predefined Database Searches
Genomic Island Table
Secondary Structure Table
Definition Table
Functional Classes Table
EC Table
PDB Table
Metabolic Pathways
Repeat Table
Codon Usage Table

Specialized Analysis
Phylogenetic Fingerprints
ABC Transporters
Base Composition Analysis

RNA Tables and Maps
Transfer RNA Table
Ribosomal RNA Table
Transfer & Ribosomal RNA Map