Bibliographic Citation
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| Title | Role of blood flow and blood flow modifiers in clinical hyperthermia therapy |
| Creator/Author | Olch, A.J. |
| Publication Date | 1986 Jan 01 |
| OSTI Identifier | OSTI ID: 6711038 |
| Resource Type | Thesis/Dissertation |
| Resource Relation | Thesis (Ph. D.) |
| Research Org | California Univ., Los Angeles (USA) |
| Subject | 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics ;560200 -- Thermal Effects; BLOOD FLOW-- INHIBITION;BLOOD FLOW-- TEMPERATURE EFFECTS;VASOCONSTRICTORS-- BIOLOGICAL EFFECTS;XENON 133-- BLOOD-PLASMA CLEARANCE; BLOOD VESSELS;COMPARTMENTS;DOGS;HYPERTHERMIA;NEOPLASMS;PATIENTS;RABBITS |
| Related Subject | ANIMALS;BETA DECAY RADIOISOTOPES;BETA-MINUS DECAY RADIOISOTOPES;BODY;BODY TEMPERATURE;CARDIOVASCULAR AGENTS;CARDIOVASCULAR SYSTEM;CLEARANCE;DAYS LIVING RADIOISOTOPES;DISEASES;DRUGS;EVEN-ODD NUCLEI;INTERMEDIATE MASS NUCLEI;INTERNAL CONVERSION RADIOISOTOPES;ISOMERIC TRANSITION ISOTOPES;ISOTOPES;MAMMALS;NUCLEI;ORGANS;RADIOISOTOPES;VERTEBRATES;XENON ISOTOPES |
| Description/Abstract | A quantitative assessment of the effect of localized magnetic-loop hyperthermia on blood flow was performed on 12 patients (19 tumor studies) using the Xenon-133 clearance method.^After it was discovered that blood flow in most of the tumors increased in response to needle injection, a physiologically based, one compartment model was developed that included both a hyperemic (transient) and a steady state component.^In the tumors of six patients, increases in blood flow induced by heat were also observed.^The same model was used to describe the measured clearance data for both types of hyperemic response.^The ability of tumor vessels to respond dynamically to stress and the degree of response may be predictive of tumor heating efficiency and subsequent therapeutic response.^Many tumors treated by hyperthermia, therefore, do not reach therapeutic temperatures (42/sup 0/C).^One explanation for this may be that some tumors react to thermal stress in a manner similar to normal tissues; i.e., they increase blood flow during hyperthermia in order to dissipate heat.^Higher temperatures might be achieved in these heat-resistant tumors by administering vasoconstrictive agents in an effort to reduce blood flow.^In the second part of this research study, the extent to which pharmacologic inhibition of local blood flow might allow higher temperatures to develop in normal muscles exposed to localized radiofrequency hyperthermia was determined.^It was found that the local muscle temperature rise could be increased by at least 90% in dogs and rabbits with the use of a local vasoconstrictive drug. |
| Publisher | Univ. of California,Los Angeles, CA |
| Country of Publication | United States |
| Language | English |
| Format | Pages: 71 |
| Availability | University Microfilms Order No. 86-14,113. |
| System Entry Date | 2001 May 13 |
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Last Updated: 02/08/2009