National Toxicology Program

American Cyanamid Co. 1991. Initial Submission: CT­470­91: Primary Dermal/Ocular Irritation Study in Albino Rabbits with Cover Letter Dated 052992. EPA TSCA Section 8ECP Test Submission. Doc. No. 88­920003288. Fiche No. OTS0536630 (1).

Anonymous. 1996. Huntsman to Boost Amines Output. Chem. Week. 158(14):5.

Beard, R.R., and J.T. Noe. 1981. Aliphatic and Alicyclic Amines. In: Patty's Industrial Hygiene and Toxicology. 3rd ed. Vol. 2B. G.D. Clayton and F.E. Clayton, Eds. A Wiley­Interscience Publication. John Wiley and Sons, New York, NY. pp. 3135-3173.

Budavari, S. (Ed.). 1996. The Merck Index, 12th ed. Merck & Co., Inc., Whitehouse Station, NJ. p. 481.

Casper, J.W., and R.P. Redman. 1995. Odor Emission to Atmosphere from Two-piece Beer and Beverage Can Manufacturing Plants. Surf. Coat. Int. 78(5):210-16. Abstract used from Chemical Abstract 123:177950.

De Silva, L. 1977. Biochemical Mechanisms and Management of Choreiform Movement Disorders. Drugs 14:300­310.

En Garde Health Products. 1997. Company home page URL http://o2.com/mind.htm.

Foureman, P., J.M. Mason, R. Valencia, and S. Zimmerling. 1994. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 Coded Compounds Tested for the National Toxicology Program. Environ. Mol. Mutagen. 23(Suppl. 1):51­63.

Gauggel, D.L., K. Sarlo, and T.N. Asquith. 1993. A Proposed Screen for Evaluating Low­Molecular­Weight Chemicals as Potential Respiratory Allergens. J. Appl. Toxicol. 13(5):307­313.

Gosselin et al. 1976. Ingredients Index: Deanol. Clinical Toxicology of Commercial Products, 4th ed. Vol. 2, p.240.

Hartung, R., and H.H. Cornish. 1968. Cholinesterase Inhibition in the Acute Toxicity of Alkyl­Substituted 2­Aminoethanols. Toxicol. Appl. Pharmacol. 12:486­494.

Haug, B.A., and M. Holzgraefe. 1991. Orofacial and Respiratory Tardive Dyskinesia: Potential Side Effects of 2­Dimethylaminoethanol (Deanol). Eur. Neurol. 31(6):423­425.

Hermansky, S.J., D.A. Neptun, E.V. Weaver, and B. Ballantyne. 1995. Clinical Pathology Changes Related to Cutaneous Irritation in the Fischer 344 Rat and New Zealand White Rabbit. J. Toxicol., Cutan. Ocul. Toxicol. 14(4):219­236.

HSDB. 1996. The Hazardous Substances Data Bank. Online database produced by the National Library of Medicine. Profile updated on 1/21/96.

Katyal, S.L., and B. Lombardi. 1978. Effects of Dietary Choline and N,N­Dimethylaminoethanol on Lung Phospholipid and Surfactant of Newborn Rats. Pediatric Res. 12:952­955.

Kiss, Z., and K.S. Crilly. 1996. Ethanolamine Analogues Stimulate DNA Synthesis by a Mechanism Not Involving Phosphatidylethanolamine Synthesis. FEBS Letters 381(1­2):67­70.

Kiss, Z., K.S. Crilly, and W.B. Anderson. 1996. Protein Kinase C Inhibitors Enhance the Synergistic Mitogenic Effects of Ethanolamine Analogues and Insulin in NIH 313. Biochem. Biophys. Res. Commun. 220(1):125­130.

Klonne, D.R., D.E. Dodd, I.M. Pritts, D.J. Nachreiner, E.H. Fowler, C.M. Troup, E.R. Homan, and B. Balllantyne. 1987. Dimethylethanolamine Acute 2­Week and 13­Week Inhalation Toxicity Studies in Rats. Fundam. Appl. Toxicol. 9(3):512­521.

Mehta, D., S. Mehta, and P. Mathew. 1976. Letter to the Editor: Failure of Deanol in Treating Tardive Dyskinesia. Am. J. Psychiatr. 133(12):1467.

Murray, M.P., and J.E. Cummins. 1979. Mutagenic Activity of Epoxy Embedding Reagents Employed in Electron Microscopy. Environ. Mutagen. 1:307­313.

Naujokaitis, S.A., J.M. Fisher, and M. Rabinovitz. 1984. Protection of Murine L1210 Leukemia and Bone Marrow Progenitor Cells Against Mechlorethamine and Inhibition of Choline Uptake as a Structure­Activity Relationship of 2­Dimethylaminoethanol and its Analogues. J. Pharm. Sci. 73(1):34­39.

Nesse, R., and B.J. Carroll. 1976. Cholinergic Side­Effects Associated With Deanol. Lancet 2:50­51.

NIOSH. 1984. National Institute for Occupational Safety and Health. National Occupational Exposure Survey (1980-1983). Cincinnati, OH: Department of Health, Education, and Welfare.

Pitts, J.N., Jr., A.M. Winer, P.L. William, G.J. Doyle, and R.A. Graham. 1980. Chemical Consequences of Air Quality Standards and of Control Implementation Programs. Statewide Air Pollution Res. Cent., Univ. California, Riverside, CA, USA, Report No. ARB-R-80/131; NTIS Order No. PB81-137697, 408 pp. Abstract from Chem. Abstract. 95:137480.

RTECS. 1996. Registry of Toxic Effects of Chemical Substances. Online database produced by National Institute of Occupational Safety and Health. Last updated October 1996.

Schlenk, D.K. 1990. Dimethylaminoethanol. In: Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Vol. 2. D.R.Buhler and D.J. Reed, Eds. Elsevier Science Publishers New York, NY. pp. 417­422.

SRI Int. 1996. Directory of Chemical Producers, United States. SRI International. Menlo Park, CA. pp. 136, 208, 293.

Stemad, W., B. Kempter, S. Wisst, I. Trick, and W. Troesch. 1995. Microbial Purification of Waste Water from Varnish Processes with Waterborne Paints. Biochem. Eng. 3, Int. Symp., 3rd, 129-31. R.D. Schmid, Ed. Universitaet Stuttgart, Institut fuer Technische Biochemie, Stuttgart, Germany. Abstract used from Chemical Abstracts 124:240919.

Stenbäck, F., J.H. Weisburger, and G.M. Williams. 1988. Effect of Lifetime Administration of Dimethylaminoethanol on Longevity, Aging Changes, and Cryptogenic Neoplasms in C3H Mice. Mechanisms Ageing Develop. 42(2):129­138.

Strum, K., Ed. 1997. Chemcyclopedia 97, Vol. 15. American Chemical Society, Washington, D.C.

Union Carbide. 1986. Initial Submission: N,N-Dimethylethanolamine: Acute Toxicity and Primary Irritancy Studies (Project Report) with Cover Sheet and Letter Dated 050592. EPA TSCA Section 8ECP Test Submission. Doc. No. 88­920002183. Fiche No. OTS0536318 (1).

Vallieres, D.W. Cockcroft, D.M. Taylor, J. Dolovich, and F.E. Hargreave. 1977. Dimethyl Ethanolamine­Induced Asthma. Am. Rev. of Respir. Dis., Vol. 115:867­ 871.

Weast, R.C., and M.J. Astle, Eds. 1980. CRC Handbook of Chemistry and Physics. CRC Press, Inc. Boca Raton, FL.

Zeiger, E., B. Anderson, S. Haworth, T. Lawlor, K. Mortelmans, and W. Speck. 1987. Salmonella Mutagenicity Tests. 3. Results from the Testing of 255 Chemicals. Environ. Mutagen. 9(Suppl. 9):1-110.

ACKNOWLEDGMENTS

Support to the National Toxicology Program for the preparation of the Toxicology of Dimethylethanolamine - Review of Literature was provided by Integrated Laboratory Systems, Inc., through NIEHS Contract Number N01-ES-65402. Contributors included: Raymond R. Tice, Ph.D. (Principal Investigator); Bonnie L. Carson, M.S. (Co-Principal Investigator); Paul W. Andrews, M.S.; Robyn H. Binder, M.E.M.; Maria E. Donner, Ph.D.; John J. Falchi, M.S.; Rodney Gilmore, B.S.; Brenda R. Hafshejani, B.S.; and Gregory G. Pazianos, B.S.

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