Stratton P, Gupta P, Kalish L, Fox H, Zorilla C, Tuomala R, Erikson N, Vajarant M, Minkoff H, Brown G, Mofenson L, Fowler M; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 3rd Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 3rd 1996 Wash D C. 1996 Jan 28-Feb 1; 3rd: 133.
NIH, Bethesda, MD.
To assess the association of immune status & squamous intrepithelial lesions (SIL) in HIV+ women, SIL rates in centrally-read first WITS Pap smears were evaluated. METHODS: Rates of SIL were compared with pregnancy status, degree of immunosuppression (CD4%; CD8%; CD4/CD8), age, race, parity, # of sexual partners, # of prior pregnancies, hx of abnormal Pap, current STDs and cigarette smoking. RESULTS: No one had cervical cancer. SIL, rates were similar for 564 pregnant and 126 nonpregnant HIV+ women (21% vs 26%, p =.19), but were higher for those with immunosuppression. (Tabular Data: See Abstract Volume). After adjusting for pregnancy and CD4, SIL rates were elevated for non-Puerto Rican hispanic women (29% vs 19%, p=.02), women with herpes (43% with vs 20% without, p=.001), gonorrhea (30% vs 21%, p = .03), bact. vaginosis (30% vs 19%, p=.009), trichomonas (25% vs 20%, p=.04), and smoking (25% vs 18%, p=.004), but were not associated with other factors. CONCLUSION: While pregnancy status seems unimportant, association of SIL with impaired immune status, STDs and smoking may predict risk of cervical dysplasia; HIV+ women with these risk factors may warrant closer surveillance.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Carcinoma in Situ
- Cervical Intraepithelial Neoplasia
- Female
- HIV Infections
- HIV Seropositivity
- Humans
- Infant
- Pregnancy
- Risk Factors
- Sexually Transmitted Diseases
- Uterine Cervical Dysplasia
- Uterine Cervical Neoplasms
- Vaginal Smears
- transmission
Other ID:
UI: 102216477
From Meeting Abstracts