Basic Search | Intermediate Search | Gene Image Map |  Home

Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap rRNA-16S-2 IGR146 IGR147 IGR149 IGR148 IGR144 IGR145 IGR150 dusA, - SMu0169 SMu0171 SMu0161 sloR, - SMu0168 sloB, - SMu0165 fimA,lraI, - SMu0166 mvaK,mvk, - SMu0163 SMu0162 dusA, - SMu0169 SMu0171 SMu0161 sloR, - SMu0168 sloB, - SMu0165 fimA,lraI, - SMu0166 mvaK,mvk, - SMu0163 SMu0162 dusA, - SMu0169 hslO, - SMu0170 hslO, - SMu0170 SMu0171 SMu0161 sloR, - SMu0168 sloB, - SMu0165 fimA,lraI, - SMu0166 mvaK,mvk, - SMu0163 SMu0162 SMu0167 sloA, - SMu0164 sloA, - SMu0164 SMu0167


LANL Gene ID: SMu0165

GenBank Locus Tag: SMU.183

DNA Molecule Name:
1  

GenBank ID:
24378697

Gene Name:
sloB  

Definition:
manganese ABC transporter permease element

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
180593

Gene Stop:
181432

Gene Length:
840

Molecular Weight*:
29965

pI*:
10.20

Net Charge*:
7.09

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: membrane spanning permease  

Gene Ontology:
Biological process
  GO:0006810    transport

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0005524    ATP binding
  GO:0042626    ATPase activity, coupled to transmembrane movement of substances


Pathway: pathway table

Primary Evidence:
Kitten,T., Munro,C.L., Michalek,S.M. and Macrina,F.L.
Genetic characterization of a streptococcus mutans LraI family
operon and role in virulence
Infect. Immun. 68 (8), 4441-4451 (2000)
PubMed: 10899841


Comment:
For other components see SMu0164 (NBD1) and SMu0166 (SBP1).


For other 'slo' genes see SMu0164 (sloA); SMu0166 (sloC); SMu0168 (sloR) and SMu1189 (sloC).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
This sequence was previously published in GenBank as gi8925938. In addition, residues 1-264 are 81% similar to gi1171961 from S.gordonii.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1531 (1e-110).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378697|ref|NP_720652.1|  putative Mn/Zn ABC transporter...   394   e-108
 gi|8925938|gb|AAF81673.1|AF232688_2  SloB [Streptococcus mut...   393   e-108
 gi|125717137|ref|YP_001034270.1|  ABC-type Mn2+/Zn2+ transpo...   343   5e-93
 gi|157075650|gb|ABV10333.1|  ABC transporter membrane-spanni...   338   2e-91
 gi|1171961|sp|P42361|P29K_STRGC  29 kDa membrane protein in ...   338   3e-91
 gi|15673299|ref|NP_267473.1|  manganese ABC transporter perm...   337   5e-91
 gi|401551|sp|P31309|P29K_STRPA  29 kDa membrane protein in f...   337   6e-91
 gi|139474303|ref|YP_001129019.1|  metal cation ABC transport...   333   9e-90
 gi|19745582|ref|NP_606718.1|  integral membrane protein MtsC...   332   1e-89
 gi|125623968|ref|YP_001032451.1|  manganese transport system...   332   1e-89


InterPro Summary:  InterProScan

InterPro
IPR001626
Family
ABC-3
PF00950 [11-267]T 2.80000504261382E-129 PF00950 ABC-3 ABC-3
noIPR
unintegrated
unintegrated
SSF81345 [4-261]T 1.3E-38 SSF81345 SSF81345 SSF81345


COGS Summary:  COGS Search
BeTs to 11 clades of COG1108
COG name: ABC-type Mn/Zn transport systems, ATPase component
Functional Class: P
The phylogenetic pattern of COG1108 is a-tk-QvCeB-H-----LINx
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
***** IPB001626 (ABC 3 transport family) with a combined E-value of 4e-108.
    IPB001626A    25-71
    IPB001626B    78-112
    IPB001626C    119-136
    IPB001626D    186-231
    IPB001626E    232-264


 ProDom Summary:  Protein Domain Search
Residues 166-265 are identical to a (MEMBRANE TRANSPORT PROTEOME COMPLETE) protein domain (PD002769 which is seen in Q9KIJ4_STRMU.

Residues 34-162 are 99% similar to a (TRANSPORT MEMBRANE TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD186109 which is seen in Q9KIJ4_STRMU.

Residues 171-265 are 31% similar to a (ZINC TRANSPORT SYSTEM TROC) protein domain (PD107828 which is seen in TROC_TREPA.

Residues 179-262 are 29% similar to a (TRANSPORT MEMBRANE METAL INNER) protein domain (PD346276 which is seen in Q9K4V5_STAXY.

Residues 154-265 are 35% similar to a (PROTEOME COMPLETE PERMEASE TRANSMEMBRANE) protein domain (PD401101 which is seen in Q9XDA5_LISMO.


Paralogs:  Local Blast Search
SMu0165 is paralogously related (blast p-value < 1e-3) to SMu1810, and SMu0905, both ABC transporter permeases.


Pfam Summary:  Pfam Search
Residues 11 to 267 (E-value = 2.5e-132) place SMu0165 in the ABC-3 family which is described as ABC 3 transport family (PF00950)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
22  
38
transmembrane  
51  
67
transmembrane  
68  
84
transmembrane  
95  
111
transmembrane  
138  
154
transmembrane  
172  
188
transmembrane  
190  
206
transmembrane  
223  
239
transmembrane  
251  
267

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MITEFIQGLYQFHFLQNALVTAIVIGIVAGAVGCFIILRGMSLMGDAISH
AVLPGVALSYILGINFFIGAIVFGLLASLIITFIKENSIIKSDTAIGITF
SSFLALGVILIGLANSSTDLFHILFGNILAVQDMDKWITVGISLLVLLFI
CLFFRPLLLTSFDPVLAKSMGLSVHFYHYLLMILLTLVSVTAMQSVGTIL
IVALLITPAATAYLYANSLKTMILLSSTLGAFASVAGLFIGYSFNIAAGS
SIVLTSALIFLISFVFAPKQRFFKKKAKK

Gene Nucleotide Sequence:  Sequence Viewer
ATGATTACAGAATTTATACAAGGCTTATATCAGTTTCATTTTTTACAAAA
TGCCTTGGTTACGGCGATTGTTATTGGTATCGTAGCAGGAGCTGTAGGCT
GTTTTATCATTCTTCGTGGAATGTCCCTTATGGGGGATGCCATTTCTCAT
GCTGTTTTGCCGGGCGTTGCCTTATCTTATATTTTGGGAATTAATTTTTT
TATTGGAGCTATTGTTTTTGGTCTTTTGGCTTCGCTCATTATCACCTTTA
TTAAGGAAAACAGCATCATTAAAAGCGATACAGCTATAGGGATAACCTTT
AGTTCTTTCTTGGCGCTGGGTGTCATTTTGATTGGTCTTGCCAATAGTTC
AACTGATTTATTTCATATTTTGTTTGGTAATATCTTGGCTGTTCAGGATA
TGGATAAGTGGATTACTGTGGGCATTTCTTTGCTTGTTCTTCTTTTTATC
TGTTTATTTTTCAGACCGCTTTTATTGACCTCTTTTGATCCTGTTTTGGC
TAAATCTATGGGGCTGTCTGTTCATTTTTACCATTATCTGTTGATGATTC
TATTGACTCTGGTTTCTGTTACAGCTATGCAGAGTGTTGGTACGATTTTA
ATTGTTGCCTTGCTCATTACTCCAGCAGCGACAGCTTACCTTTATGCCAA
TAGCTTAAAAACCATGATTTTATTATCGTCAACTTTAGGTGCTTTTGCTT
CCGTTGCCGGGCTCTTTATCGGCTATAGTTTTAATATTGCAGCGGGTTCA
AGCATTGTCTTAACCTCAGCACTTATCTTTTTGATTTCTTTTGTTTTTGC
ACCCAAGCAAAGATTTTTTAAGAAAAAAGCAAAAAAATAA

Los Alamos National Laboratory • Est 1943

Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy