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Title EFFECT OF ETHIONINE, 6-MERCAPTOPURINE, AND IRRADIATION WITH X RAYS AND GAMMA RAYS ON THE INCREASED METABOLISM OF MEPROBAMATE INDUCED BY PRETREATMENT WITH LUMINAL
Creator/Author Kato, R. ; Chiesara, E.
Publication Date1960 Jan 01
OSTI IdentifierOSTI ID: 4641170
Resource TypeJournal Article
Resource RelationAtti Accad. Med. Lombarda; Vol: 15
Research OrgUniversita, Milan
SubjectBIOLOGY AND MEDICINE; BODY; CARBAMATES; COBALT 60; DRUGS; ENZYMES; ETHIONINE; GAMMA RADIATION; LIVER; LUMINAL; METABOLISM; MILK; NUCLEIC ACIDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PURINES; RADIATION DOSES; RATS; X RADIATION
Description/Abstract When rats were pretreated with phenobarbital (Luminal), liver slices showed an increased ability to catabolize meprobamate 12-48 hr later. The effects of ethionine, 6-mercaptopurine and x and gamma radiation on this increase of meprobamate metabolism were studied. Single wholebody 750-r x-ray and 700- or 2100-r Co/sup 60/ gamma -ray doses were given 6 to 12 hr after injection of phenobarbital. When 250 mg/kg ethionine was injected 30 min before phenobarbital administration, the induction of increased metabolism was completely inhibited. If ethionine was administered after phenobarbital, the inhibitory effect was markedly decreased. Such decrease was dependent on the time interval between the pretreatment and ethionine administration. In contrast, 8-mercaptopurine and x or gamma radiation did not inhibit the induction of increased metabolism of meprobamate. It is suggested that the increased drug metabolism after phenobarbital treatment depends on the biosynthesis of nucleic acids which then control elaboration of the liver apoenzyme. Although 6-mercaptopurine and ionizing radiation are known to inhibit nucleic acid synthesis, they apparentiy do not affect the precursors of the meprobamate-metabolizing enzyme system. (H.H.D.)
LanguageItalian
FormatPages: 392-6
System Entry Date2001 Jun 03

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