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Title Analysis of mammalian tumor vascularization in the development of a therapy to prevent metastasis
Creator/Author D`Amico, A.V.
Publication Date1986 Apr 29
OSTI IdentifierOSTI ID: 5526602; DE86013122
Report Number(s)DOE/OR/00033-T200
DOE Contract NumberAC05-76OR00033
Resource TypeTechnical Report
Resource RelationPortions of this document are illegible in microfiche products. Thesis
Research OrgMassachusetts Inst. of Tech., Cambridge (USA)
Subject550900 -- Pathology ;550700 -- Microbiology; BLOOD VESSELS-- PATHOLOGICAL CHANGES;EXPERIMENTAL NEOPLASMS-- VASCULAR DISEASES;METASTASES;NECROSIS-- PHYSIOLOGY;THROMBIN-- THERAPEUTIC USES; CARCINOMAS;ELECTRON MICROSCOPY;EXPERIMENTAL DATA;KIDNEYS;MORPHOLOGY;RATS
Related SubjectANIMALS;BODY;CARDIOVASCULAR SYSTEM;COAGULANTS;DATA;DISEASES;DRUGS;ENZYMES;HEMATOLOGIC AGENTS;HEMOSTATICS;HYDROLASES;INFORMATION;MAMMALS;MICROSCOPY;NEOPLASMS;NUMERICAL DATA;ORGANS;PATHOLOGICAL CHANGES;PEPTIDE HYDROLASES;RODENTS;SERINE PROTEINASES;USES;VERTEBRATES
Description/Abstract In this investigation the use of thrombin as both a tumor growth inhibitor and anti-metastatic agent is studied using transplantable renal, adenocarcinoma and rhabdomyosarcoma.^The administration of one bolus injection of thrombin to the tumor necrotic region at six weeks post-implantation (pre-metastatic) prolongs the time to metastasis to approximately twenty weeks post-implantation (or roughly double the life expectancy following tumor implantation) depending on the tumor diameter at the time the thrombin is delivered.^In addition, the growth rate of the primary tumor is considerably decreased probably due to vascular thrombosis of the tumor vasculature leading to increased ischemia and subsequent tumor necrosis.^The results of the morphological examination and the success of the thrombin therapy provide evidence for the existence of a radially directed open vessel pathway in the metastatic process.^From the results of the students` t-test on the morphological data one can assert that inward directed radial tumor vasculature exists.^Two classes of these inward radial tumor vessels are found: Class 1 consists of vessels that are not active mitotically but are open-ended; Class 2 consists of vessels that are active mitotically (i.e., growing) but are closed-ended; indicating the growth of new tumor vasculature.^Class 1 tumor vessels may provide the entrance into which thrombin can permeate and fill the entire tumor parenchyma resulting in both tumor toxic and anti-metastatic effects.^(30 refs., 24 figs., 8 tabs.)
Country of PublicationUnited States
LanguageEnglish
FormatPages: 123
AvailabilityNTIS, PC A06/MF A01; 1.
System Entry Date2001 May 13

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