Energy Citations Database

Bibliographic Citation

 
Document
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title Multivariate modeling of PCB bioaccumulation in three-spined stickleback (Gasterosteus aculeatus)
Creator/Author Bavel, B. van ; Andersson, P. ; Wingfors, H. ; Bergqvist, P.A. ; Rappe, C. ; Tysklind, M. [Umeaa Univ. (Sweden). Inst. of Environmental Chemistry] ; Aahgren, J. ; Norrgren, L. [Swedish Univ. of Agricultural Sciences, Uppsala (Sweden)]
Publication Date1996 Jun 01
OSTI IdentifierOSTI ID: 264303
Other Number(s)ETOCDK; ISSN 0730-7268
Resource TypeJournal Article
Resource RelationEnvironmental Toxicology and Chemistry ; VOL. 15 ; ISSUE: 6 ; PBD: Jun 1996
Subject54 ENVIRONMENTAL SCIENCES ;56 BIOLOGY AND MEDICINE, APPLIED STUDIES ; WATER POLLUTION; BIOLOGICAL INDICATORS; FISHES; SENSITIVITY; POLYCHLORINATED BIPHENYLS; BIOLOGICAL ACCUMULATION; MULTIVARIATE ANALYSIS; MATHEMATICAL MODELS; STRUCTURE-ACTIVITY RELATIONSHIPS; FORECASTING; TOXICITY; PHYSICAL PROPERTIES; CHEMICAL PROPERTIES
Description/Abstract Three-spined sticklebacks were exposed to 20 polychlorinated biphenyls (PCBs) through gastrointestinal intake. The PCBs, viz. 2,2{prime},3,4-TeCB, 2,2{prime},4,6{prime}-TeCB, 2,3,3{prime},5{prime}-TeCB, 2,3,4,4{prime}-TeCB, 2,3{prime},4,5{prime}-TeCB, 3,3{prime},4,5-TeCB, 2,2{prime},3,4{prime},6-PeCB, 2,2{prime},4,4{prime},5-PeCB, 2,2{prime},4,6,6{prime}-PeCB, 2,3,3{prime},5,6-PeCB, 2,3,4,4{prime},6-PeCB, 3,3{prime}4,4{prime}5-PeCB, 2,2{prime},3,4,5,6{prime}-HxCB, 2,2{prime},4,4{prime},5,5{prime}-HxCB, 3,3{prime},4,4{prime},5,5{prime}-HxCB, 2,2{prime},3,3{prime},4,5,6-HpCB, 2,2{prime},3,4,4{prime},6,6{prime}-HpCB, 2,2{prime},3,4{prime},5,6,6{prime}-HpCB, 2,3,3{prime},4,4{prime},5,6-HpCB, and 2,3,3{prime},4{prime},5,5{prime},6-HpCB, were selected by means of a full factorial design in combination with principal component analyses based on several physicochemical properties of tetra- through hepta-PCBs. After exposure to the training set, pooled samples of the sticklebacks were analyzed by GC-MS after lipid determination and cleanup using Florisil open-column chromatography. Bioaccumulation factors (BAFs) were calculated on a lipid basis by dividing the PCB concentrations in the fish by the respective concentrations in the feed. Higher chlorinated PCBs showed, in general, higher bioaccumulation than the lower chlorinated congeners. Polychlorinated biphenyls with vicinal hydrogens in the meta- and para-positions exhibited low bioaccumulation. Finally, 18 of the 20 measured BAFs were used to calculate a multivariate quantitative structure-activity relationship (QSAR) by means of partial least squares fitting to latent structures. By applying this QSAR, the bioaccumulation potentials of 136 nontested tetra- through hepta-PCB congeners were predicted.
Country of PublicationUnited States
LanguageEnglish
Formatpp. 947-954 ; PL:
System Entry Date2001 May 04

Top