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Fusobacterium nucleatum Search Results

Record: 1 of 1  
MiniMap IGR1649 IGR1648 IGR1647 IGR1644 IGR1643 IGR1642 IGR1650 IGR1646 IGR1645 ebsC, - FN1373 rnhB, - FN1371 FN1374 rluD, - FN1372 FN1381 citD,cilG, - FN1378 citE, - FN1379 pycA,oadA, - FN1376 citP,citS,citC,citN, - FN1375 citF,cilA, - FN1380 ebsC, - FN1373 rnhB, - FN1371 FN1374 rluD, - FN1372 FN1381 citD,cilG, - FN1378 citE, - FN1379 pycA,oadA, - FN1376 citP,citS,citC,citN, - FN1375 citF,cilA, - FN1380 Type: tandem, Name: FN-TR-120 - 120 Type: tandem, Name: FN-TR-120 - 120 ebsC, - FN1373 rnhB, - FN1371 FN1374 rluD, - FN1372 FN1381 citE, - FN1379 pycA,oadA, - FN1376 citP,citS,citC,citN, - FN1375 citF,cilA, - FN1380 citG,citX, - FN1377 citG,citX, - FN1377 citD,cilG, - FN1378


Gene ID:FN1376

DNA Molecule Name:
1  

GenBank ID:
19715027

Gene Name:
pycA  oadA  

Definition:
oxaloacetate decarboxylase alpha chain

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
2024019

Gene Stop:
2025365

Gene Length:
1347

Molecular Weight*:
50666

pI*:
6.90

Net Charge*:
-0.36

EC:
4.1.1.3  

Functional Class:
Transport and binding proteins; Cations  

Gene Ontology:
Biological process
  GO:0008152    metabolic process

Molecular function
  GO:0003824    catalytic activity


Pathway: pathway table
Arginine and proline metabolism
Pentose and glucuronate interconversions
Pyruvate metabolism

Secondary Evidence:
Velayudhan J, Kelly DJ.
Analysis of gluconeogenic and anaplerotic enzymes in Campylobacter jejuni: an essential role for phosphoenolpyruvate carboxykinase.
Microbiology. 2002 Mar;148(Pt 3):685-94.
PMID: 11882702

Jain B, Brand BC, Lück PC, Di Berardino M, Dimroth P, Hacker J.
An oxaloacetate decarboxylase homologue protein influences the intracellular survival of Legionella pneumophila.
FEMS Microbiol Lett. 1996 Dec;145(2):273-9.
PMID: 8961567

Comment:
The oxaloacetate decarboxylase beta chain (oadB) nucleotide sequence from Haemophilus ducreyi (in GenBank) has a very high correlation (e-94) to Glutaconyl-COA subunit B FN0201.

View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
This sequence corresponds to 19704711 in GenBank. It also corresponds to RFNV00850, a predicted oadA protein in the vincentii subspecies.

Nearest neighbor is 20807663 from Thermoanaerobacter tengcongensis.

Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|19704711|ref|NP_604273.1|  oxaloacetate decarboxylase [Fu...   886   0.0  
 gi|34763815|ref|ZP_00144726.1|  Oxaloacetate decarboxylase a...   863   0.0  
 gi|148324537|gb|EDK89787.1|  oxaloacetate decarboxylase [Fus...   859   0.0  
 gi|150390400|ref|YP_001320449.1|  Conserved carboxylase regi...   608   e-172
 gi|106894328|ref|ZP_01361448.1|  Pyruvate carboxyltransferas...   595   e-168
 gi|94990532|ref|YP_598632.1|  Na+ transporting oxaloacetate ...   594   e-168
 gi|150390968|ref|YP_001321017.1|  Conserved carboxylase regi...   593   e-168
 gi|19746127|ref|NP_607263.1|  oxaloacetate decarboxylase [St...   593   e-168
 gi|50914244|ref|YP_060216.1|  oxaloacetate decarboxylase [St...   593   e-167
 gi|71903547|ref|YP_280350.1|  oxaloacetate decarboxylase [St...   592   e-167


InterPro Summary:  InterProScan

InterPro
IPR000891
Domain
Pyruvate carboxyltransferase
PF00682 [12-276]T 2.9e-49 PF00682 HMGL-like HMGL-like
PS50991 [4-264]T 38.771 PS50991 PYR_CT PYR_CT
InterPro
IPR003379
Domain
Conserved carboxylase region
PF02436 [294-447]T 2.2e-42 PF02436 PYC_OADA PYC_OADA
InterPro
IPR013785
Domain
Aldolase-type TIM barrel
G3DSA:3.20.20.70 [2-270]T 5.6e-71 G3DSA:3.20.20.70 no description no description
noIPR
unintegrated
unintegrated
PTHR18866 [2-448]T 5e-221 PTHR18866 CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE
PTHR18866:SF1 [2-448]T 5e-221 PTHR18866:SF1 PYRUVATE CARBOXYLASE PYRUVATE CARBOXYLASE


COGS Summary:  COGS Search
BeTs to 10 clades of COG1038
COG name: Pyruvate carboxylase, C-terminal domain/oxaloacetate decarboxylase, alpha subunit
Functional Class:? E
The phylogenetic pattern of COG1038 is amtkYQv--br------l---
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB003379 (Conserved carboxylase domain) with a combined E-value of 4.1e-148.
    IPB003379A    6-28
    IPB003379B    41-69
    IPB003379C    70-96
    IPB003379D    97-132
    IPB003379E    152-195
    IPB003379F    196-241
    IPB003379G    287-331


 ProDom Summary:  Protein Domain Search
Residues 4-117 are 69% similar to a (PYRUVATE CARBOXYLASE BIOTIN LIGASE) protein domain (PD002904 which is seen in Q9HH18_METBA.

Residues 156-270 are 42% similar to a (CARBOXYLASE PYRUVATE BIOTIN LIGASE) protein domain (PD414942 which is seen in Q9CHQ7_LACLA.

Residues 156-269 are 53% similar to a (PYRUVATE CARBOXYLASE BIOTIN PROTEOME) protein domain (PD414925 which is seen in PYCB_METTH.

Residues 118-154 are 59% similar to a (SUBUNIT PROTEOME COMPLETE ALPHA) protein domain (PD378263 which is seen in Q9WXY2_THEMA.

Residues 270-441 are 55% similar to a (PYRUVATE CARBOXYLASE BIOTIN LIGASE PROTEOME COMPLETE) protein domain (PD328972 which is seen in Q9HH18_METBA.

Residues 162-268 are 48% similar to a (LYASE SYNTHASE HOMOCITRATE FIXATION) protein domain (PD344479 which is seen in O58564_PYRHO.

Residues 118-269 are 57% similar to a (LYASE SYNTHASE 2-ISOPROPYLMALATE COMPLETE) protein domain (PD327958 which is seen in PYCB_METJA.


Paralogs:  Local Blast Search
FN1376 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 12 to 276 (E-value = 2.5e-49) place FN1376 in the HMGL-like family which is described as HMGL-like (PF00682)
Residues 294 to 448 (E-value = 1.5e-40) place FN1376 in the PYC_OADA family which is described as Conserved carboxylase domain (PF02436)

 Top PDB Hits:
No hits to the PDB database.

Gene Protein Sequence:
VNKIKIMETCLRDGHQSLMATRLTTAEMLPIIEKLDSVGYHSLEMWGGAT
FDAALRFLNEDPWERLREIKKRVKNTKLQMLLRGQNLLGYRNYADDIVER
FVKKSIQNGIDIVRIFDALNDVRNLQTACKATKKYGGHAQLAMSYTISPV
HTVEYYKNLALEMQEIGADSIAIKDMSGILLPEVAYELVRELKSVLRVPV
EVHTHATAGLASMTYIKAVEAGADIIDTAISPLSGGTSQPATESIVRAFQ
GTERETGFDLELLKEIAEYFKPIRAKYLQEGILNPQALMTEPSIVEYQLP
GGMLSNFLSQLKMQKAEHKYEDVLREIPRVRKDLGYPPLVTPLSQMVGTQ
AIFNILTGQRYKLIPNEIKNYVRGFYGKSPVPISDEIKKTIIFNEEVFTG
RPADKLAPEYDKLVEETRNFARSEEDVLSYALFPQVAKDFLIKKYANE$

Gene Nucleotide Sequence:  Sequence Viewer
GTGAATAAGATTAAAATTATGGAAACTTGTCTGAGAGATGGACATCAATC
ACTTATGGCTACTCGTTTAACTACTGCTGAAATGTTACCAATAATTGAAA
AATTAGATAGTGTTGGTTACCACTCATTAGAAATGTGGGGAGGAGCAACT
TTTGATGCTGCTTTAAGATTTCTAAATGAAGATCCCTGGGAAAGATTGAG
AGAAATTAAAAAGAGAGTTAAAAATACAAAACTTCAAATGCTACTTAGAG
GACAAAACCTTTTAGGTTACCGTAATTATGCAGATGATATAGTTGAAAGA
TTTGTTAAAAAATCTATACAAAACGGAATAGACATAGTTCGTATATTTGA
TGCTTTAAATGATGTTCGTAATCTACAAACTGCTTGTAAAGCTACAAAAA
AATATGGTGGTCATGCTCAACTTGCTATGAGTTACACTATAAGTCCTGTT
CACACTGTTGAGTATTATAAAAATTTAGCTTTAGAAATGCAAGAAATTGG
TGCAGACTCTATTGCTATAAAAGATATGTCTGGAATTTTATTACCAGAAG
TTGCTTACGAATTAGTAAGAGAATTAAAATCTGTTTTAAGAGTTCCTGTT
GAAGTACATACTCATGCAACTGCTGGACTTGCGAGTATGACTTATATCAA
AGCTGTTGAAGCAGGAGCAGATATAATTGATACTGCTATATCTCCTTTAT
CTGGTGGAACTTCTCAACCTGCTACTGAAAGTATTGTTAGAGCTTTCCAA
GGAACTGAAAGAGAAACTGGTTTTGACTTAGAATTATTAAAAGAAATAGC
AGAATATTTCAAACCTATAAGAGCAAAATACTTACAAGAAGGTATCTTAA
ATCCTCAAGCTCTTATGACTGAACCAAGTATAGTTGAATATCAATTACCA
GGTGGAATGTTATCTAACTTCCTTTCTCAATTAAAAATGCAAAAAGCAGA
ACATAAATATGAAGATGTTTTAAGAGAAATCCCAAGAGTAAGAAAAGACT
TAGGATATCCACCTCTAGTTACTCCACTTAGCCAAATGGTAGGAACACAG
GCTATATTCAATATTTTAACTGGACAAAGATATAAATTGATACCAAATGA
AATTAAAAACTATGTGAGAGGATTTTATGGTAAAAGCCCAGTACCTATAT
CTGATGAAATAAAAAAGACTATTATTTTTAATGAAGAAGTGTTCACTGGA
AGACCTGCTGATAAATTAGCACCTGAATATGATAAATTAGTTGAAGAAAC
AAGAAACTTTGCAAGAAGTGAAGAAGATGTATTATCTTATGCTCTTTTCC
CACAAGTTGCAAAAGATTTCTTAATAAAGAAATATGCAAATGAATAG

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