BIOGRAPHICAL SKETCH

Provide the following information for the key personnel in the order listed on Form Page 2.
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NAME
POSITION TITLE
Grant T. Gullberg
Senior Staff Scientist
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
NSTITUTION AND LOCATION
DEGREE(if applicable)
YEAR(s)
FIELD OF STUDY
Seattle Pacific University, Seattle, WA
B.S.
1966
Mathematics
University of Washington, Seattle, WA
M.S.
1971
Mathematics
University of California, Berkeley, CA
Ph.D.
1979
Biophysics


Positions and Employment
1967-1971	Engineer, Boeing Company, Renton, WA
1972-1980	Staff Scientist, Lawrence Berkeley Laboratory, Berkeley, CA
1980-1985	Senior Physicist, General Electric Co., Medical Systems, Waukesha, WI
1983-1995	Adjunct Assistant Professor, Dept. of Radiology, University of Washington, Seattle, WA
1985-1988	Assistant Professor, Dept. of Radiology, University of Utah, Salt Lake City, UT
1988-1994	Associate Professor, Department of Radiology, University of Utah, Salt Lake City, UT
1994-2002	Professor, Department of Radiology, University of Utah, Salt Lake City, UT
2002-present	Senior Staff Scientist, Lawrence Berkeley National Laboratory, Berkeley, CA
2002-present	Adjunct Professor, Department of Radiology, University of California at San Francisco
Other Experience
1989-1997	Director, Medical Imaging Research Laboratory, University of Utah, Salt Lake City, UT
1997-2001	Director, Nuclear Medicine Research Division, University of Utah, Salt Lake City, UT
Honors 
1995-present	Editorial Board, Journal of Nuclear Cardiology
1997-2003	International Advisory Board, Physics in Medicine and Biology
1992-1999	Associate Editor, IEEE Transactions on Medical Imaging
1999	Medical Imaging Conference Chairman, 1999 IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, WA
2004-present	Fellow, IEEE

Selected peer-reviewed publications (37 selected from 147 refereed publications)

1.	Zeng GL, Gullberg GT: Iterative and analytical reconstruction algorithms for varying-focal-length cone-beam projections. Phys Med Biol 43:811-821, 1998.
2.	Huesman RH, Reutter BW, Zeng GL, Gullberg GT. Kinetic parameter estimation from SPECT cone-beam projection measurements. Phys Med Biol 43:973-982, 1998.
3.	Frey EC, Tsui BMW, Gullberg. Improved estimation of the detector response function for converging beam collimators. Phys Med Biol 43:941-950, 1998.
4.	Basko R, Zeng GL, Gullberg GT. Application of spherical harmonics to image reconstruction for the Compton camera. Phys Med Biol 43:887-894, 1998.
5.	Hsieh Y-L, Zeng GL, Gullberg GT. Projection space image reconstruction using strip functions to calculate pixels more "natural" for modeling the geometric response of the SPECT collimator. IEEE Trans on Med Imag 17:24-44, 1998.
6.	Gullberg GT, Morgan HT, Zeng GL, Christian PE, Di Bella EVR, Tung C-H, Maniawski PJ, Hsieh Y-L, Datz FL. The design and performance of a simultaneous transmission and emission tomography system. IEEE Trans on Nucl Sci 45:1676-1698, 1998.
7.	Reutter BW, Gullberg GT, Huesman RH. Kinetic parameter estimation from attenuated SPECT projection measurements. IEEE Trans on Nucl Sci 45:3007-3013, 1998. 
8.	DiBella EVR, Clackdoyle R, Gullberg GT. Blind estimation of compartmental model parameters. Phys Med Biol 44:765-780, 1999.
9.	Kadrmas DJ, DiBella EVR, Huesman RH, Gullberg GT. Analytical propagation of errors in dynamic SPECT: estimators, degrading factors, bias, and noise. Phys Med Biol 44:1997-2014, 1999.
10.	Gullberg GT, Ghosh RD, Zeng GL, Alexander AL, Parker DL: Tensor tomography. IEEE Trans on Nucl Sci 46:991-1000, 1999.
11.	Zeng GL, Bai C, Gullberg GT. A projector/backprojector with slice-to-slice blurring for efficient 3D scatter modeling. IEEE Trans on Med Imag 18:722-732, 1999.
12.	Zeng GL, Gullberg GT. A slice-by-slice blurring model and kernel evaluation using the Klein-Nishina formula for 3D scatter compensation in parallel and converging beam SPECT. Phys Med Biol 45:1275-1307, 2000.
13.	Rutter BW, Gullberg GT, Huesman RH. Direct least squares estimation of spatiotemporal distributions from dynamic SPECT projections using a spatial segmentation and temporal B-splines. IEEE Trans on Med Imag 19:434-450, 2000.
14.	Zeng GL, Gullberg GT. Unmatched projector/backprojector pairs in an iterative reconstruction algorithm. IEEE Trans on Med Imag 19:548-555, 2000. 
15.	Di Bella EVR, Khare HS, Kadrmas DJ, Gullberg GT. SPECT imaging of teboroxime during myocardial blood flow changes. IEEE Trans on Nucl Sci 47:982-988, 2000.
16.	Kadrmas DJ, Di Bella EVR, Khare HS, Christian PE, Gullberg GT. Static versus dynamic teboroxime myocardial perfusion SPECT in canines. IEEE Trans on Nucl Sci 47:1112-1117, 2000. 
17.	Sitek A, Di Bella EVR, Gullberg GT. Factor analysis with a priori knowledge application in dynamic cardiac SPECT. Phys Med Biol 45:2619-2638, 2000.
18.	Laurette I, Zeng GL, Welch A, Christian PE, Gullberg GT. A three-dimensional ray-driven attenuation, scatter and geometric response correction technique for SPECT in inhomogeneous media. Phys Med Biol. 45(11):3459-80, 2000.
19.	Gullberg GT, Defrise M, Panin VY, Zeng GL. Efficient cardiac diffusion tensor MRI by three-dimensional reconstruction of solenoidal tensor fields. Magn Reson Imaging. 19(2):233-56, 2001.
20.	Kadrmas DJ, Gullberg GT. 4D maximum a posteriori reconstruction in dynamic SPECT using a compartmental model-based prior. Phys Med Biol.46(5):1553-74, 2001.
21.	Taguchi K, Zeng GL, Gullberg GT. Cone-beam image reconstruction using spherical harmonics. Phys Med Biol. 46:N127-N138, 2001. 
22.	Feng B, Sitek A, Gullberg GT. The prolate spheroidal transform for the gated SPECT. IEEE Trans on Nucl Sci. 48:872-875, 2001.
23.	Khare HS, Di Bella EVR, Kadrmas DJ, Christian PE, Gullberg GT. Comparison of static and dynamic cardiac perfusion thallium-201 SPECT. IEEE Trans on Nucl Sci. 48:774-779, 2001.
24.	Feng B, Veress A, Sitek A, Gullberg GT, Ghosh Roy D. Estimation of mechanical properties from gated SPECT and cine MRI data using a finite element mechanical model of the left ventricle. IEEE Trans on Nucl Sci. 48:725-733, 2001.
25.	Gullberg GT, Di Bella EVR, Sinusas A. Editorial - Estimation of coronary flow reserve: Can SPECT compete with other modalities? J Nucl Cardiol. 8:620-625, 2001.
26.	Sitek A, Gullberg GT, Di Bella EVR, Celler A. Reconstruction of dynamic renal tomographic data acquired by slow rotation. J Nucl Med. 42:1704-1712, 2001.
27.	Sitek A, Gullberg GT, Huesman RH. Correction for ambiguous solutions in factor analysis using a penalized least squares objective. IEEE Trans Med Imaging. 21(3):216-225, 2002.
28.	Sitek A, Di Bella EV, Gullberg GT, Huesman RH. Removal of liver activity contamination in teboroxime dynamic cardiac SPECT imaging with the use of factor analysis. J Nucl Card. 9(2):197-205, 2002.
29.	Feng B, Sitek A, Gullberg GT: Calculation of the LVEF without edge detection - application to smaller hearts. J Nucl Med 43:786-794, 2002.
30.	Reutter BW, Gullberg GT, Huesman RH: Effects of temporal modeling on the statistical uncertainty of spatiotemporal distributions estimated directly from dynamic cone-beam SPECT projections. Phys Med Biol 47:2673-2683, 2002.
31.	Panin VY, Zeng GL, Defrise M, Gullberg GT: Diffusion tensor MR imaging of principal directions: A tensor tomography approach. Phys Med Biol 47:2737-2757, 2002.
32.	Sitek A, Klein GJ, Gullberg GT, Huesman RH: Deformable model of the heart with fiber structure. IEEE Trans on Nucl Sci 49:789-793, 2002.
33. Veress AI, Weiss JA, Gullberg GT, Vince DG, Rabbitt RD: Strain measurement in coronary arteries using intravascular ultrasound and deformable images. ASME J Biomech Eng 124:734-741, 2002.
34. Zeng GL, Gullberg GT, Christian P, Gagnon D: Cone-beam iterative reconstruction of a segment of a long object. IEEE Trans on Nucl Sci 49:37-41, 2002. 
35. Zeng GL, Gullberg GT: A channelized Hotelling-trace collimator design method based on reconstruction rather than projections. IEEE Trans on Nucl Sci 49:2155-2158, 2002.
36. Panin VY, Zeng GL, Gullberg GT: Regularized iterative reconstruction in tensor tomography using gradient constraints. IEEE Trans on Nucl Sci 49:2387-2393, 2002.
37. Bal H, Di Bella EVR, Gullberg GT: Parametric image formation using clustering for dynamic cardiac SPECT. IEEE Trans on Nucl Sci 50:1584-1589, 2003.
Research Support

Ongoing:

5 R01 HL39792 (PI: Gullberg)	07/01/02-03/31/06
NIH/NHLBI
Improved Cardiac SPECT with Convergent Hole Collimators
Major goals are to design collimators and algorithms for converging geometry single photon emission computed tomography. Algorithms include the correction for the physical effects of attenuation, scatter, geometric point response, and motion. Also included in the research is the development of mechanical models for the heart that are determined from SPECT and carefully evaluated in spontaneous hypertensive rats.
Role: PI

Completed During the Last Three Years:

5 R01 HL50663-08 (PI: Gullberg)	01/01/95-04/30/03
NIH/NHLBI
Dynamic Cardiac SPECT Imaging
The goal of this proposal is to develop methods that use existing single- and multi-detector SPECT systems; and, in so doing, make dynamic SPECT useful even in those clinics which have only single-detector SPECT systems and are thus not able to perform rapid acquisitions. Resubmitted 11/01/03 for competitive continuation.
Role: PI

P20 HL68566 (PI: Johnson)	06/01/01-05/31/04
NIH/NHLBI 
Program for Computational Functional Imaging and Visualization
Major goals are to develop, implement, and test methods for diffusion imaging in the heart and its importance in modeling ECG/MCG inverse problems. (Dr. Gullberg's participation in this project ended when he left the University of Utah to join the Lawrence Berkeley National Laboratory.)
Role: Co-PI

Picker/Marconi Medical Systems, Inc. (PI: Gullberg)	02/15/88-06/31/01
Advanced Development Research in Single Photon Emission Computed Tomography
Major goals were to develop hardware and algorithms for modeling and correcting for the physics of the imaging process in single photon emission computed tomography.
Role: PI

Bracco Diagnostics, Inc. (PI: Gullberg)	01/01/02-06/31/02
A Clinical Evaluation to Determine Optimal Imaging Parameters for Tc-99m Teboroxime in Subjects With Coronary Artery Disease and Subjects With No Coronary Artery Disease
Major goals are to develop an optimum imaging protocol for imaging the rapidly exchanging radiopharmaceutical teboroxime-Tc-99m.
Role: PI
I.  Literature Cited.



PHS 398/2590 (Rev. 05/01)	Page ____	Biographical Sketch Format Page
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