Human pancreatic secretion and intestinal motility: effects of ileal nutrient perfusion.

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Title:	Human pancreatic secretion and intestinal motility: effects of ileal nutrient perfusion.
Author:	Layer, P : Peschel, S : Schlesinger, T : Goebell, H
Citation:	Am-J-Physiol. 1990 Feb; 258(2 Pt 1): G196-201
Abstract:	To study the effects of intraileal nutrients on human pancreatic secretion and gastrointestinal motility, nine healthy subjects were intubated with an oroileal multilumen tube for ileal perfusion, duodenal juice aspiration, and intestinal motility recording. The duodenum was perfused continuously with essential amino acids to induce submaximal stimulation of pancreatic enzyme secretion and fed motility pattern. Additional ileal perfusion with carbohydrate at quantities similar to those observed under physiological late postprandial conditions or fat at isocaloric loads significantly decreased pancreatic enzyme outputs by greater than 80% (P less than 0.001) compared with saline. Ileal carbohydrate or fat induced a duodenal motor activity front that migrated distally and was followed by reduced motility. In summary, ileal delivery of small quantities of nutrient markedly decreased endogenously stimulated pancreatic enzyme secretion in humans. This was associated with specific changes in fed intestinal motility that converted to patterns characteristic of the interdigestive state. Our findings suggest that the distal small intestine may participate in the late postprandial regulation of gastrointestinal function in humans.
Review References:	None
Notes:	Copyright American Physiological Society. Abstracts are reprinted by the permission of the publisher of the journal for volume, pages, and dates cited. Hypertext links to electronic journal sites, if available, can be found in the the Peer Reviewed Journal List on the IBIDS home page.
Language:	English
Publication Type:	Journal-Article
Keywords:	Amylases secretion : Dietary Carbohydrates : Dietary Fats : Gastrointestinal Motility : Ileum physiology : Intestine, Small physiology : Pancreas enzymology : Pyloric Antrum physiology
URL:	http://ajpcon.physiology.org/