Imaging Perfusion, Oxygenation and Angiogenesis in the Peripheral Microcirculation (RFA DK-02-001)
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Description:
There is a need to apply imaging techniques to measure perfusion or tissue oxygenation at the level of the microvasculature in peripheral skeletal muscle of diabetic patients, in order to determine risk for development of microvascular complications such as neuropathy that can lead to loss of sensation and the development of wounds in the hands and feet. Very early detection of defective perfusion may help to identify those patients who would benefit from close monitoring and intensive treatment. The NIDDK is also interested in imaging angiogenesis and inflammation for the monitoring of wound healing in diabetes. The ultimate goal of this initiative is to develop an inexpensive method for screening newly diagnosed patients and patients under care for diabetes.
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