Rubbert A, Bock E, Schwab J, Marienhagen J, Nusslein H, Wolf F, Kalden JR; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 422 (abstract no. PO-B16-1722).
Dep of Medicine III, University of Erlangen, Germany.
Central nervous system involvement occurs frequently in patients with HIV infection, leading to a variety of unique disorders. While CT or MRI inconsistently show atrophy or white matter abnormalities, cerebral perfusion defects as measured by 99m-Tc-HMPAO SPECT were detected in a substantial proportion of patients with early and advanced disease. In the present study, 99m-Tc-HMPAO SPECT was performed in 23 patients with HIV infection and results were correlated to serological and clinical parameters. Normal SPECT findings were present in 11/24 patients; focal and diffuse uptake defects were detected in 6/24 and 7/24 patients, respectively. There was a significant association (p = 0.02) between the presence of anti-cardiolipin antibodies (ACA) and brain perfusion defects, especially ACA were detected in all patients with focal uptake defects. No association between SPECT findings and clinical parameters, CD4 cell count, circulating immune complexes or surrogate markers like beta 2-microglobulin and neopterin was observed. Our results suggest a possible implication of autoimmune mechanisms in brain perfusion abnormalities detected in HIV-infected patients by SPECT scanning. However, further studies are needed to evaluate the clinical significance of these findings.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Antibodies, Anticardiolipin
- Brain
- Brain Diseases
- CD4 Lymphocyte Count
- HIV Infections
- HIV Seropositivity
- Humans
- Magnetic Resonance Imaging
- Perfusion
- Technetium Tc 99m Exametazime
- Tomography, Emission-Computed, Single-Photon
- radionuclide imaging
Other ID:
UI: 102204677
From Meeting Abstracts