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Technical Report Availability: o-Benzyl-p-Chlorophenol (TR-444)
[Notices]
[Page 19306]
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program (NTP); Availability of Technical Report on Toxicology and Carcinogenesis Studies of oBenzylpChlorophenol
The HHS' National Toxicology Program announces the availability of the NTP Technical Report on the toxicology and carcinogenesis studies of obenzyl-p-chlorophenol. o-Benzyl-p-chlorophenol, an aryl halide, is a broad spectrum germicide used in disinfectant solutions and soap formulations in United States hospitals and households. Human exposure to o-benzyl-p-chlorophenol occurs by absorption through the skin and mucous membranes and by ingestion.
Toxicology and carcinogenicity studies were conducted by dermal administration of o-benzyl-p-chlorophenol to groups of 50 Swiss (CD-1®) mice of each sex to study its effect as an initiator, promoter, and complete carcinogen.
Under the conditions of the 1-year mouse skin initiation/promotion study in Swiss (CD-1®) mice, o-benzyl-p-chlorophenol was a cutaneous irritant and a weak skin tumor promoter relative to strong promoters such as 12-o-tetradecanoylphorbol-13-acetate. o-Benzyl-p-chlorophenol had no activity as an initiator or as a complete carcinogen.
Questions or comments about the Technical Report should be directed to Central Data Management at P.O. Box 12233, Research Triangle Park, NC 27709 or telephone (919) 541-3419.
Copies of Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CAS No. 120-32-1) (TR-444) are available without charge from Central Data Management, NIEHS, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709; telephone (919) 541-3419 or send e-mail to CDM@niehs.nih.gov.
Dated: March 27, 1996
________________________________
Kenneth Olden, Ph.D.
Director
National Toxicology Program
[Billing Code 4140-01]
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