2-Chlorophenol (CASRN 95-57-8)
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0303
2-Chlorophenol; CASRN 95-57-8
Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of chronic toxicity data by U.S. EPA health scientists from several Program Offices and the Office of Research and Development. The summaries presented in Sections I and II represent a consensus reached in the review process. Background information and explanations of the methods used to derive the values given in IRIS are provided in the Background Documents.
STATUS OF DATA FOR 2-Chlorophenol
File First On-Line 08/22/1988
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 07/01/1993 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — 2-Chlorophenol
CASRN — 95-57-8
Last Revised — 07/01/1993
The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Please refer to the Background Document for an elaboration of these concepts. RfDs can also be derived for the noncarcinogenic health effects of substances that are also carcinogens. Therefore, it is essential to refer to other sources of information concerning the carcinogenicity of this substance. If the U.S. EPA has evaluated this substance for potential human carcinogenicity, a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Reproductive effects Rat Subchronic Exon and Koller, 1982 |
NOAEL: 5 mg/kg/day LOAEL: 50 mg/kg/day |
1000
|
1
|
5E-3
mg/kg/day |
*Conversion Factors: Assuming a rat drinks a daily amount of water equal to 10% of its body weight, 50 mg/L x 0.1 L/kg/day = 5 mg/kg/day and 500 mg/L x 0.1 L/kg/day = 50 mg/kg/day
__I.A.2. Principal and Supporting Studies (Oral RfD)
Exon, J.H. and L.D. Koller. 1982. Effects of transplacental exposure to chlorinated phenols. Environ. Health Perspect. 46: 137-140.
Groups of 12-20 weanling female Sprague-Dawley rats were exposed to 0, 5, 50 or 500 ppm of 2-chlorophenol in the drinking water. The rats were bred after 10 weeks of 2-chlorophenol treatment. Treatment was continued during breeding, gestation and weaning. Parameters evaluated included percent conception, litter size, birth weight, weaning weight, number of stillbirths and hematology (hematocrit, hemoglobin levels, red and white cell counts and mean corpuscular volume) in weanling rats. An increase in the conception rate and in the number of stillborns as well as a decrease in the size of the litters was observed in the rats exposed to 500 ppm, the LOAEL. No effects were observed at 50 ppm, which can be converted to a dosage of 5 mg/kg/day. Dividing the NOAEL of 5 mg/kg/day by an uncertainty factor of 1000 yields the RfD of 0.005 mg/kg/day, or 0.4 mg/day for a 70 kg human.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — 10 to account for interspecies extrapolation, 10 for intraspecies variability and 10 for the use of subchronic data.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
No chronic or subchronic oral or inhalation toxicity studies of 2-chlorophenol were available to support the NOEL. 2-Chlorophenol has not been studied for teratogenicity.
__I.A.5. Confidence in the Oral RfD
Study — Low
Database — Low
RfD — Low
Confidence in the study is low because, although it was a subchronic oral study, it evaluated only reproductive and hemotological effects. The data base is rated as low because no other subchronic, chronic, carcinogenicity or teratogenicity studies were available. Because of the low confidence in the study and database, the level of confidence in the RfD is low.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — U.S. EPA, 1986a,b
U.S. EPA, 1986a received extensive Agency-wide and limited external review, 1986.
U.S. EPA, 1986b received ECAO-CIN Internal Review and limited Agency Review, 1986.
Other EPA Documentation — None
Agency Work Group Review — 12/15/1987, 01/20/1988
Verification Date — 01/20/1988
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for 2-Chlorophenol conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
lease contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — 2-Chlorophenol
CASRN — 95-57-8
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — 2-Chlorophenol
CASRN — 95-57-8
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — 2-Chlorophenol
CASRN — 95-57-8
Last Revised — 07/01/1993
_VI.A. Oral RfD References
Exon, J.H. and L.D. Koller. 1982. Effects of transplacental exposure to chlorinated phenols. Environ. Health Perspect. 46: 137-140.
U.S. EPA. 1986a. Drinking Water Criteria Document for Chlorophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC.
U.S. EPA. 1986b. Health Effects Assessment for Selected Chlorinated Phenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — 2-Chlorophenol
CASRN — 95-57-8
Date |
Section |
Description |
---|---|---|
08/22/1988 | I.A. | Oral RfD summary on-line |
08/01/1989 | VI. | Bibliography on-line |
01/01/1992 | I.A.7. | Secondary contact changed |
01/01/1992 | IV. | Regulatory Action section on-line |
07/01/1993 | I.A.6. | Documentation clarified |
07/01/1993 | VI.C. | References clarified |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — 2-Chlorophenol
CASRN — 95-57-8
Last Revised — 08/22/1988
- 95-57-8
- Chlorophenol, 2-
- o-chlorophenol, liquid
- o-chlorophenol
- o-chlorophenol, solid
- o-chlorphenol
- phenol, 2-chloro-
- phenol, o-chloro-
- RCRA waste number U048
- UN 2020
- UN 2021