TORO C, MONEO I, CABALLERO ML, ALARCON T, RUBIO M, LOPEZ-BREA M, BAQUERO M; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. P-924.

Hospital Carlos III, Madrid, Spain

Objective: To study if the sensibilization to A. simplex in dyspeptic patients could be related to other epidemiological factors than consumption of raw fish. Patients and METHODS: One hundred and seventy-four patients (61 men, 83 women, mean age 49.3, age range 21-80) submitted to gastric endoscopy by suffering dyspeptic symptoms were studied. Specific IgE detection against A. simplex was performed by immunoblotting. Age, sex, social status, fish consumption (raw, in vinegar, smoked and cooked), and quantitative information on smoking and alcohol consumption were recorded. RESULTS: Forty-one (23.6%) patients presented IgE anti-A. simplex (20 men, 21 women). The seroprevalence increased with the age but decreased in patients over 64 years (P<0.05). No relationship was established between the detection of IgE anti-A. simplex and social status. The ingestion of raw, in vinegar and smoked fish was associated with the presence of IgE anti-A. simplex (P<0.05). The consumption of alcohol and tobacco showed a dose-dependently positive association with the detection of antibody against A. simplex (P=0.006 and P=0.001, respectively). The logistic regression analysis found a statistically relationship only among the presence of IgE anti-A. simplex, the consumption of raw and in vinegar fish, and smoking. CONCLUSIONS: Detection of IgE anti-A. simplex was associated with smoking apart from other well-known factors as the ingestion of raw and in vinegar fish. The activity of anisakis larvae increased with low pH and could be more infective. Therefore, increased gastric acidity in the stomach through smoking may be a cause of the dose-dependently positive association between IgE anti-A. simplex and smoking.

Publication Types:

• Meeting Abstracts

Keywords:

• Animals
• Anisakiasis
• Anisakis
• Cookery
• Female
• Fishes
• Humans
• Immunoblotting
• Larva
• Male
• Seroepidemiologic Studies
• Smoke
• Stomach Diseases

Other ID:

• GWAIDS0030471

UI: 102270108

From Meeting Abstracts