National Toxicology Program

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. ¹

Human Toxicity Excerpts

• PATIENTS WITH RECURRENT URTICARIA OR ANGIOEDEMA WERE PROVOKED WITH SULFANILIC ACID. NO URTICARIAL REACTION FROM SULFANILIC ACID WAS NOTED. [MICHAELSSON G, JUHLIN L; URTICARIA INDUCED BY PRESERVATIVES AND DYE ADDITIVES IN FOOD AND DRUGS; BR J DERMATOL 88(6) 525 (1973)]**PEER REVIEWED**
  

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Non-Human Toxicity Excerpts

• SULFANILIC ACID WAS NONMUTAGENIC IN THE SALMONELLA TYPHIMURIUM/MAMMALIAN MICROSOMAL MUTAGENICITY TEST. [CHUNG K-T ET AL; MUTAGENICITY TESTING OF SOME COMMONLY USED DYES; APPL ENVIRON MICROBIOL 42(4) 641 (1981)]**PEER REVIEWED**
  
• CHRONIC DAILY IP INJECTION OF SULFANILIC ACID DURING FIRST POSTNATAL MONTH TO RATS CAUSED HYPERACTIVITY & IMPAIRED SHOCK ESCAPE PERFORMANCE IN PUPS. [GOLDENRING JR ET AL; SULFANILIC ACID: BEHAVIORAL CHANGE RELATED TO AZO FOOD DYES IN DEVELOPING RATS; NEUROBEHAV TOXICOL TERATOL 4(1) 43 (1982)]**PEER REVIEWED**
  

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Human Toxicity Values

• None found

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Non-Human Toxicity Values

• None found

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Absorption, Distribution and Excretion

• WHEN SULFANILIC ACID WAS ADMINISTERED ORALLY TO RATS, 53% OF THE ADMINISTERED DOSE WAS FOUND IN THE URINE. [SCHELINE RR, LONGBERG B; THE ABSORPTION, METABOLISM AND EXCRETION OF THE SULFONATED AZO DYE, ACID YELLOW, BY RATS; ACTA PHARMACOL TOXICOL 23(1) (1965)]**PEER REVIEWED**
  

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Metabolism/Metabolites

• YIELDS P-ACETAMIDOBENZENESULFONIC ACID IN RABBIT: DANIEL, JW, TOXICOL APPL PHARMAC, 4, 572 (1962). /FROM TABLE/ [Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. S-14]**PEER REVIEWED**
  

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TSCA Test Submissions

• None found

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Footnotes

¹ Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.