DAVID Gene Report
1254640
interleukin 8 Related Genes Synthetic construct
REFSEQ_PROTEIN
NP_000575 ,
ENTREZ_GENE_SUMMARY
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.,
REFSEQ_MRNA
NM_000584 ,
GENPEPT_ACCESSION
AAA35611 ,
AAA36323 ,
AAA52849 ,
AAA59158 ,
AAA63206 ,
AAA66353 ,
AAA74722 ,
AAB21773 ,
AAB23944 ,
AAH13615 ,
AAK00048 ,
AAK60276 ,
AAP35730 ,
ABM84653 ,
ABM92181 ,
BAA03245 ,
CAA61140 ,
CAA68742 ,
CAA77745 ,
CAG46948 ,
EAX05687 ,
EAX05688 ,
EAX05689 ,
GENE_SYMBOL
IL8 ,
GENE_NAME
Interleukin-8 precursor (IL-8) (C-X-C motif chemokine 8) (Monocyte- derived neutrophil chemotactic factor) (MDNCF) (T-cell chemotactic factor) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Emoctakin) [Contains: MDNCF-a (IL8/NAP1 form I) (GCP/IL-8 protein IV); Interleukin-8 (IL-8(1-77)) (MDNCF-b) (IL8/NAP1 form II) (GCP/IL-8 protein II) ((Ala-IL-8)77); IL- 8(5-77); IL-8(6-77) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (Neutrophil-activating factor) (NAF) (MDNCF-c) (IL8/NAP1 form III) (GCP/IL-8 protein I) ((Ser-IL-8)72); IL-8(7-77) (IL8/NAP1 form IV) (GCP/IL-8 protein V); IL-8(8-77) (IL8/NAP1 form V) (GCP/IL-8 protein VI); IL-8(9-77) (IL8/NAP1 form VI) (GCP/IL-8 protein III)],
interleukin 8,
GENERIF_SUMMARY
This lithium-induced up-regulation of NF-kappa B and MAP kinase activation was associated with an enhancement of interleukin-8 mRNA accumulation as well as an increase in interleukin-8 protein release. ,
Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells ,
Conformational changes of dimeric IL-8 induced by heparan sulfate, but not by heparin, refer to an "activation" of the chemokine which is hypothesized to be important for the migration of neutrophils to inflammatory sites. ,
IFN-gamma primed CD14(high) human gingival fibroblasts to enhance production of IL-8 in response to LPS through augmentation of the CD14-TLR system ,
Increased plasma levels of interleukin-6 and interleukin-8 are observed in beta-thalassaemia major patients and may be relevant in the pathophysiology of beta-thalassaemia ,
Human bronchial epithelium releases neutrophil chemotactic factor. ,
Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells. Lidocaine inhibits the expression of il-8 mRNA. ,
secretion induced by combined effects of protein kinase C and ERK activation with TFF-papetide and TNF-alpha ,
TNF-alpha induction of IL-8 in vascular endothelium is down-regulated in vitro via an eotaxin/CCL11-induced acceleration of IL-8 mRNA decay. ,
Cushing's syndrome patients have markedly elevated levels of the proinflammatory cytokine IL-8 ,
The effect of LPS on neutrophils from patients with high risk of type 1 diabetes mellitus in relation to IL-8, IL-10 and IL-12 production and apoptosis in vitro. ,
mechanical strain increased interleukin-8 protein expression ,
Mycobacterium bovis-mediated upregulation of IL-8 biosynthesis and release by human monocytes involves intracellular protein kinase signaling pathways and transcription factor NF-kappa B. ,
process of cervical dilatation during parturition at term is associated with an increased expression of interleukin-1 beta, interleukin-6 and interleukin-8 mRNA in the lower uterine segment ,
Expression of IL8 in primary gastrointestinal non-Hodgkin's lymphoma. ,
Secretion levels of sIL-2R, IL-6, IL-8, IL-10, and TNF-alpha, but not IL-4 and IL-12, are elevated in activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders. ,
IL-8 is down regulated in ovarian carcinoma and in serous effusions ,
determine the cellular contents and concentrations of interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor alpha (TNF-alpha) in fluids of patients with spermatocele or epididymal cyst ,
TF-FVIIa signaling induced increased transcription as well as mRNA stabilization leading to the significant up-regulation of IL-8 protein synthesis ,
Inflammatory cytokines mediate C-C (monocyte chemotactic protein 1) and C-X-C (interleukin 8) chemokine expression in human pleural fibroblasts. ,
REVIEW ,
IL8 is overexpressed in paclitaxel-resistant human osteosarcoma cells ,
Huh7 cells expressing the hepatitis C viral protein NS5A showed an up-regulation of interleukin-8 ,
expression in airway epithelial cells by interleukin-17 ,
regulation of secretion in bronchial epithelial cells by phospholipase D activation by sphingosine 1-phosphate ,
Weight loss in obese subjects was associated with opposite changes in the secretion and transcription of IL-8 and TNF-alpha in the adipose tissue, as well as in plasma ,
IL-8 production by RET tyrosine kinase is regulated by multiple signaling pathways ,
Endogenous expression in nasopharyngeal carcinoma cells ,
TNFalpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells. ,
Native LDL potentiate TNF alpha and IL-8 production by human mononuclear cells. ,
Mycobacterium bovis-mediated upregulation of IL8 in human monocyes is down-regulated by IL10. ,
Glutamine decreases production of this and il6 but not nitric oxide and prostaglandins e(2) production by human gut in-vitro. ,
Endotoxin-stimulated production is increased in short-term cultures of whole blood from healthy term neonates. ,
Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase. ,
plays a role in the pathogenesis of the otitis media with effusion (review) ,
new autocrine function of secreted interleukin-8 and the intracellular signal transduction leading to the regulation of cytosolic calcium and to a migratory tumor cell phenotype ,
Simvastatin reduces expression of the proinflammatory cytokine interleukin-8 in circulating monocytes from hypercholesterolemic patients. ,
Leishmania promastigotes release a granulocyte chemotactic factor and induce interleukin-8 release by neutrophil granulocytes ,
Induction of IL-8 in THP-1 macrophages and human microvascular endothelial cells during Bartonella henselae infection ,
interleukin-8 secretion from Mycobacterium tuberculosis-infected monocytes is regulated by protein tyrosine kinases ,
Induction of interleukin 8 release from the HMC-1 mast cell line ,
IL-8 gene transcription is induced by p38 MAP kinase via AP-1 in hVMSCs ,
The expression of IL-1beta mRNA and IL-8 mRNA was increased significantly in patients with ulcerative colitis UC ,
in infants with respiratory syncytial virus bronchiolitis, the proportion of RANTES relative to IL-8 was significantly increases ,
stimulation of secretion by sphingosine 1-phosphate ,
Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages. ,
Results describe a novel action of proteasome inhibitors, possibly through reactive oxygen species production, of targeting the upstream signaling molecules Ras, ERK and JNK, which leads to AP-1 activation and interleukin-8 gene expression. ,
expression in colon carcinoma cells exposed to pyrrolidine dithiocarbamate ,
human papillomavirus type 16 E6 and E7 repress IL-8 transcription through effects on CREB binding protein/p300 and P/CAF ,
Normal and SV40 transfected human peritoneal mesothelial cells produce IL-6 and IL-8 ,
These results demonstrate that Rho family small GTPases RhoA, Rac1 and Cdc42 are novel signal transducers for SP-stimulated IL-8 expression. ,
Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.(AP-1) ,
enhances the migration of bone marrow stromal cells ,
released from lung epithelial cells rendered necrotic by influenza A virus infection ,
The endogenous levels of TPO, IL-6 and IL-8 are elevated in the thrombocytopenic patients with AML and MDS. ,
treatment of neutrophils with pneumolysin either alone or in combination with the chemotactic tripeptide, N-formyl-l-methionyl-l-leucyl-l-phenylalanine resulted in a time-dependent increase in synthesis and release of IL-8 ,
Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8. ,
Regulation of human airway epithelial cell IL-8 expression by MAP kinases. ,
human IL8 expression mediates elements of the systemic inflammatory response in pancreatic tumor cell lines ,
Elevated expression of IL-8 (and not PTHrP) by MDA-MET cells is a phenotypic change that may be related to their enhanced ability to metastasize to the skeleton. ,
plasma IL-8 levels are increased in obese subjects, and are related to fat mass and TNF-alpha system ,
Enterohaemorrhagic Escherichia coli O157 ,
Pressure-induced IL-8 production was inhibited by PKC activity. ,
IL-8 increases gap junctional intercellular communication in cultured fibroblasts and induces a more rapid maturation of granulation tissue. ,
mediates angiogenesis in Kaposi's sarcoma ,
Circulating ICAM-1, IL-8, and MCP-1 in untreated obstructive sleep apnea were significantly greater than in controls. nCPAP therapy could reduce OSAS-induced hypoxia and generation of inflammatory mediators. ,
We used specific pharmacologic inhibitors to identify the signalling molecules which lead to interleukin (IL)-8 and MCP-1 production in human monocytes in response to M. tuberculosis infection ,
some heat-stable component of P. gingivalis, including LPS, may be responsible for the induction of IL-8 and MCP-1 in HUVECs by a CD14-dependent mechanism ,
Interleukin-8-has a role in proliferation, survival, and MMP production in CXCR1 and CXCR2 expressing HUVECs ,
expressed in CSF of children with bacterial or viral meningitis ,
Activation of the p38 MAPK and ERK1/2 pathways is required for Fas-induced production in colonic epithelial cells ,
mediation of angiogenic effects by CXCR2 ,
Elevated serusm levels of this protein in advanced non-small cell lung cancer are related to prognosis. ,
results revealed that Porphyromonas gingivalis induces the expression of IL-8 and MCP-1 mRNAs in vascular endothelial cells, but bacterial proteases degrade both chemokines ,
interleukin 8 induced by IL-1beta via activation of NF-kappaB in granulosa cells may have a role in the periovulatory period of follicular maturation ,
the relationship between interleukin (IL)-8, IL-1beta and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis positive ,
IL-8 is over-expressed in cutaneous melanoma; no direct correlation was found between IL-8 expression and survival; it would appear that IL-8 plays a major role in melanoma development. ,
role in inducing CXC chemokine GCP-2/CXCL6 in mesenchymal cells ,
Follicular growth & increased capillary vessel densities were seen in rats after hIL-8 injection. IL-8 can participate in follicular development. It may play important roles in ovulation & luteinization among mediators induced by endogenous LH. ,
spontaneous release of IL-8 and IL-1ra by airway neutrophils was significantly higher than that from blood neutrophils in cystic fibrosis ,
Elevated levels of IL-8 are found in brains of patients with HIV-1 encephalitis; inhibition of long-term potentiation in IL-8-perfused rat hippocampus suggests that it plays a role in cognitive dysfunction associated with HIV-1-associated dementia. ,
Data show that hydrogen peroxide induced a time-dependent increase in histone acetylation that was maintained for 12 hours, and was associated with increased IL-8 production. ,
Acetylation of H4 mediated by air pollutant particles was associated with the promoter region of the IL-8 gene ,
Upregulation of this cytokine by infiltrating macrophages correlates with tumor angiogenesis and patient survival in non-small cell lung cancer. ,
Data show that inhibition of endogenous RhoA, Rac1, and Cdc42 by their respective dominant negative mutants inhibits neurotensin-induced interleukin-8 protein production and promoter activity. ,
CSMCs respond to LPS with increased expression of IL-8 mRNA and secreted IL-8, and that expression of matrix metabolizing enzymes in CSMCs is not directly affected by IL-8. IL-8 produced by CSMCs in response to gram-negative infection ,
3-aminobenzamide inhibited gene expression of interleukin-8 induced by hydrogen peroxide. ,
Concentrations of IL-8 were significantly higher in patients than in controls in luteal phase. Red lesions were associated with significantly increased levels of peritoneal fluid IL-8 only in luteal phase. ,
The mechanism of IL-8 regulation of angiogenesis may be in part due to enhanced proliferation and survival of endothelial cells by differential expression of anti-apoptosis genes and in part by activation of matrix metalloproteinases MMP-2 and MMP-9. ,
Neutrophil recruitment to inflammatory sites is mediated by two related receptors ,
IL-8 regulates MMP-2 activity and plays an important role in the invasiveness of human pancreatic cancer ,
Expression of interleukin-8 in human fallopian tube epithelial and stromal cells differs. Expression in response to inflammatory cytokines such as interleukin-1alpha and tumor necrosis factor-alpha varies. May be important in pathogenesis of salpingitis. ,
stretch of airway smooth muscle causes production of interleukin-8 by activating CCAAT/enhancer-binding protein and activator protein-1 transcription factor through activation of extracellular regulated kinase-1 and 2 and p38 kinase signaling pathways ,
Data show that ergothioneine abolished the transcriptional activation of interleukin-8 (IL-8) in human alveolar epithelial cells. ,
There is a significan correlation of IL-8 to age, total fructose, immunoglobulin G (IgG) concentration and leucocyte count. ,
binds to heparan sulfate and chondroitin sulfate in lung tissue ,
FliC of enteropathogenic Escherichia coli is sufficient to induce IL-8 release in T84 cells and that activation of the Erk and p38 pathways is required for IL-8 induction ,
mast cells may play an active role in the angiogenesis of basal cell carcinoma through the production of IL-8 ,
individuals with interleukin-8-251TT and interleukin-10-819TT, a combination presumably causing mild inflammation, have a higher probability of the continuing Helicobacter pylori infection, especially among current smokers. ,
results indicate that epithelial TLR5 mediates p38 activation and subsequently regulates flagellin-induced IL-8 expression independently of NF-kappaB, probably by influencing IL-8 mRNA translation ,
Pretreatment of monocytic cells with low TNF doses inhibited TNF-induced (restimulation with a high dose) IL-8 promoter-dependent transcription as well as IL-8 production, which was prevented by overexpression of C/EBPbeta, but not p65 or Oct-1. ,
IL-8 increased by 30% after weight loss. IL-8 and IL-6 correlated with measures of insulin resistance, and changes in IL-6 but not IL-8 were correlated with improvement in insulin sensitivity after weight loss. ,
Candida albicans induce expression of il-8 in cultured epidermal keratinocyttes. ,
These observations indicate that von Willebrand factor plays an active role in sequestering interleukin-8 into Weibel-Palade bodies. ,
enhanced expression in Helicobacter pylori infection of gastric mucosa; significant association with bacteria load, chronic inflammation and activity ,
The role of IL8 in cultured nasal epithelial cells was studied for its ability to synthesize and deliver neutrophil chemotactic factors following TNF-alpha induction. ,
Abrogation of MRP-14 activity with a specific antibody reduced the IL-8-stimulating potential of bronchial secretions, suggesting it was a stimulus to IL-8 production in the lung and may amplify neutrophilic inflammation in bronchial disease ,
IL-8 regulation by bradykinin involves prostanoid-dependent activation of AP-1 and NF-LI-6 and prostanoid-independent activation of NF-kappaB ,
IL8 transcription is induced when oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine binds to a 37-kDa GPI-anchored protein, which interacts with TLR4 ,
IL-8 is upregulated by neutrophil elastase via toll-like receptor 4 ,
Stimulation of conjunctival epithelium with TNF-alpha and/or IFN-gamma generated release of the chemotactic factors IL-8 and RANTES, which could act to prolong inflammation. May prolong inflammation by recruiting eosinophils to the ocular surface. ,
results indicate that RBC, when interacting with extracellular matrix, may participate in the recruitment of inflammatory cells by stimulating fibroblasts to secrete IL-8. ,
Data report the location and level of interleukin (IL)-8 and TGF-beta2 expression in the fimbrial compartment of fallopian tubes and IL-10 expression in the endometrium of women with pyoinflammatory adnexal diseases. ,
These results show that cathepsin L is secreted from human fibroblasts in response to external stimuli and plays an important role in IL-8 processing in inflammatory sites. ,
IL8 selectively recruited a single NF-kB subunit. ,
Bombesin stimulates nuclear factor kappa B activation and expression of this angiogenic factor in prostate cancer cells. ,
Common polymorphisms in this protein are associated with increased risk of colorectal cancer. ,
The lack of glutamine increases IL-8 production by Caco-2 cells after LPS stimulation ,
Higher cytosol IL8 levels were found in the walls of ruptured aneurysms than in the asmptomatic aneurysms. ,
IL-8 is regulated by NF-kappaB and has a role in mediating angiogenesis and metastasis of human bladder cancer ,
Serum amyloid A appears to be important mediator of inflammatory process, possibly contributing to pool of IL-8 produced in chronic diseases, which may play a role in degenerative diseases. ,
serum and cyst fluid levels of interleukin (IL)-6, IL-8 and tumour necrosis factor-alpha (TNF-alpha) were evaluated in women with endometriomas and compared with those in women with benign or malignant ovarian tumours. ,
adipose tissue mRNA of tumor necrosis factor-alpha, interleukin-6, and interleukin-8 was increased in HIV-associated lipodystrophy syndrome subjects ,
Relationship of polymorphism at this locus to susceptibility to E. coli-associated diarrhea. ,
effects of interleukin (IL)-15 on human polymorphonuclear leukocyte (PMNL) activity against Aspergillus and IL-8 release were investigated ,
Significant relationship between IL-8 levels in drainage veins and both gastric tumor size and lymph node metastasis. ,
Increased shedding of IL-8 bound to a trimolecular complex with heparan sulfate and syndecan-1 in cultured vascular endothelium is associated with plasmin activity and inhibition of neutrophil transendothelial migration. ,
Although an intact promoter NF-kappa B site is crucial to macrophage IL-8 production, only LPS-stimulated production appears to require additional nuclear translocation of NF-kappa B. ,
IL-8 is implicated as a potent activator of the bone destruction common in metastatic bone disease. ,
Differential interleukin-8 and nitric oxide production in epithelial cells induced by mucosally invasive and noninvasive Trypanosoma cruzi trypomastigotes. ,
IL8 is overexpressed in human fat cells from insulin-resistant subjects ,
Induces human neutrophils to produce IL-8 (more in smokers) through the generation of peroxynitrite and subsequent activation of NF-kappaB. ,
Data suggest that the elevated circulating levels of IL-8 in obese subjects is due to the release of IL-8 from nonfat cells in adipose tissue. ,
differential IL-8 expression in macrophages infected with M. tuberculosis and M. marinum may be critically associated with distinct host responses in tuberculosis ,
Up-regulation of interleukin-8 by novel small cytoplasmic molecules of nontypeable Haemophilus influenzae via p38 and extracellular signal-regulated kinase pathways. ,
saliva CD14 promoted the invasion of oral epithelial cells by A. actinomycetemcomitans and consequently augmented the production of IL-8, playing an important role in innate immunity in the oral cavity ,
Recombinant IL-8 induces articular chondrocyte hypertrophy and calcification through p38 MAP kinase and transglutaminase 2. ,
PAI-1 and IL-8 secretion are increased by glucose ,
Increase in IL-8 is independent of nuclear factor kappaB activation and is associated with an increase in c-Jun N-terminal kinase and activator protein-1 activity. ,
an aberrant DNA methylation pattern may be responsible for the differences in IL-8 release between high and low metastatic breast carcinoma cell lines ,
IL-8 is regulated by MEF (ELF4) in human cells ,
Data show that tumor necrosis factor-alpha priming significantly enhanced interleukin (IL)-8 secretion in response to concentrated ambient particles and other urban air particles in HTB54 cells. ,
Some levels, such as interleukin-6 and interleukin-8, may fluctuate during normal pregnancy. These spontaneous variations during pregnancy must be taken into account when mucosal immunologic responses to lower genital tract infection are being studied. ,
Microvessel endothelium of fetal placental vasculature produces both interleukin-6 and interleukin-8 in umbilical placental vascular disease. May play key role in interaction of endothelial cells of placenta villi with neighboring cells. ,
data identified Rac1 as a key intermediate in Yersinia enterocolitica invasin-triggered IL-8 synthesis and demonstrated that maximum IL-8 induction involves several MAP kinase cascades ,
both NF-kappa B and C/EBP beta transcription factors were cross-linked to the il-8 promoter after IL-1 treatment ,
Cockroach proteases and PAR-2 activation synergistically increase TNF-alpha-induced IL-8 transcription via activation of ERK in bronchial epithelial cells ,
The relative IL-8 mRNA expression levels were significantly higher in esophageal mucosa of esophageal reflux patients than in normal controls. ,
significant negative correlation between the concentrations of IL-8 and oxygen in ovarian follicular fluid ,
elevated serum interleukin-8 is associated with venous invasion, and advanced pathological tumor-node-metastasis stage of hepatocellular carcinoma ,
role of Vibrio cholerae hemagglutinin protease (hap) in the induction of IL-8 in intestinal epithelial T84 cells ,
minor trauma to skin may induce expression of E-selectin, ICAM-1 and IL-8 ,
significantly higher in supernatants from Hepatitis C virus-infected primary human macrophage cultures. ,
The expression of IL-8 and IL-18 mRNAs was down-regulated from the third or fourth gestational month (GM) until the eighth or ninth GM, respectively, and both increased before the onset of labor ,
Anti-IL-8 ,
Results indicate that neutrophil elastase activates p38 MAP kinase which upregulates NF-kappaB and AP-1 activities, thus inducing interleukin-8 mRNA expression and protein synthesis. ,
IL-8 may play an important role in the local gastric and duodenal mucosal inflammatory infiltration with a large number of neutrophils when there is Helicobacter pylori infection. ,
IL-8 confers androgen-independent growth and migration of prostatic cells. ,
Trichomonas vaginalis-induced neutrophil recruitment may be mediated via the IL-8 expressed by neutrophils in response to activation by live T. vaginalis. ,
IL-8 is a primary regulator of monocyte adhesion to EC in response to glucose. It accounts for almost 50% of glucose-mediated monocyte adhesion. The regulation of IL-8 production in EC by glucose does not appear to be through PPAR[alpha]. ,
Peripheral blood monocytes upregulated both tumor ENA-78 and IL-8 mRNA and protein. Alveolar macrophages only upregulated ENA-78 mRNA and protein. ,
Reactive oxygen species regulate immune signaling through TLR4 mediated NF-kappa B activation and Il-8 expression ,
IL-8 was generated upon exposure of lung organ culture to adenovirus 7 ,
The mucosal inflammatory response to H. pylori infection is complex and involves different pathways converging on the IL-8 promoter. ,
Expression of IL-8 was markedly upregulated by nitric oxide. ,
in non-transformed human colonocytes, MEK activation following flagellin/TLR5 engagement is a key modulator for NFkappaB-independent, IL-8 and MIP3alpha expression. ,
mRNA abundance of IL-6 and IL-8 appears to be influenced by glycogen availability in the contracting muscle. ,
Collagen II-reactive T cells in rheumatoid arthritis joints can increase the production of chemokines such as IL-8, MCP-1, and MIP-1 alpha through interaction with synoviocytes. ,
CD28-stimulated T cells actively secrete IL-8, and Bcl-xL up-regulation protects T cells from radiation-induced apoptosis ,
haplotype-specific increase in transcription may cause susceptibility to Respiratory Syncytial Virus-induced bronchiolitis ,
Data show that oxidant-injured and stressed airway epithelial cells upregulate thioredoxin, but produce little IL-8, which may be important in airway epithelial cell-mediated multistep navigation of neutrophils to sites of oxidant injury. ,
Human airway trypsin-like protease might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis. ,
Promoter polymorphism of the IL-8 gene is associated with Parkinson's disease. ,
Ox-PAPC-mediated IL-8 expression in endothelial cells is regulated by the c-src kinase/STAT3 pathway ,
MIF may play an important role in the migration of inflammatory cells into the synovium of rheumatoid joints via induction of IL-8. ,
concetration in children with acute lymphoblbastic leukemia after chemotherapy ,
Both motility and adherence to intestinal epithelial cells (Int407)are possible triggering factors contributing to IL-8 mRNA expression by Vibrio cholera. ,
Nitric oxide induction of IL-8 gene expression could be a significant contributing factor in the initiation and induction of inflammatory response in the respiratory epithelium. ,
Among apparently healthy men and women, elevated levels of IL-8 are associated with an increased risk of future coronary artery disease. These prospective data support a role for IL-8 in the development of CAD events. ,
This is the first evidence of the involvement of ROS and calcium/calcineurin in IgE-dependent IL-8 production. ,
Data show that IL-8/CXCL8 is consistently transcribed and expressed in fetal intestinal tissue, in a developmentally regulated inverse relationship with gestational maturation. ,
data suggest that cyclic mechanical stretch of the uterine cervix by the presenting part of the fetus during labour may augment both IL-8 and MCP-3 production in the uterine cervix via AP-1 activation. ,
Candida albicans and Saccharomyes cerevisiae stimulated Caco-2 cells to produce IL-8 only in the presence of butyric acid, a metabolite produced by intestinal bacteria. S. cerevisiae zymosan and glucan also enhanced IL-8 secretion. Treatment of Caco ,
We believe that H. pylori-related cytokine activation becomes concentrated on gastric mucosa and this pathogen-induced local inflammatory cascade does not cause changes in circulatory levels of these cytokines. ,
Activation of NF-kappaB is an important signal transduction pathway in M. bovis-induced IL-8 secretion in monocytic or epithelial cells. Calcium influx had a direct effect on IL-8 secretion in U937 cells or HEp-2 cells infected with M. bovis. ,
IL-8 gene overexpression in breast cancer requires a complex cooperation between NF-kappaB, AP-1 and C/EBP transcription factors. ,
MAPK-AP-1 and ROS-NF-kappaB signaling pathways are involved in the IL-1beta-induced IL-8 expression and that these paracrine signaling pathways induce endothelial cell proliferation ,
IL-6 and IL-8 levels in all amniotic fluids and in all supernatants ,
downregulation in leukocytes in Crohn's disease ,
IL8 production by dengue virus infected monolayers contributes to the virus-induced effect on the cytoskeleton and tight junctions and thereby modifies transendothelial permeability. ,
interleukin 8 interleukin 8 precursor emoctakin protein 3-10C LUCT/interleukin-8 CXC chemokine ligand 8 T cell ,
IL-8 production in response to serotype VIII Group B Streptococcus was significantly higher (P < 0.001) than that in response to serotype III in A549 epithelial cells. ,
PIV-4 infection enhances epithelial IL-8 and IL-6 production by transcriptional and posttranscriptional mechanisms. ,
Peptide fragments of gliadin induced interleukin (IL)-8 and tumour necrosis factor-alpha (TNF-alpha) production in a monocytic cell line. ,
interleukin-8 secretion and NF-kappaB activation is induced by Protein kinase Cdelta mediated lysophosphatidic acid in human bronchial epithelial cells ,
CXCR1 defined a novel interleukin-8/CXC ligand 8 (IL-8/CXCL8)-responsive CD8 T-cell subset that was enriched in perforin, granzyme B, and interferon-gamma, and had high cytotoxic potential ,
IL-8 may have a role in the neutrophilic promotion of the metastatic phenotype ,
IL-1beta-dependent prolonged EGFR transactivation involves multiple pathways, including an IL-8-dependent pathway. ,
alterations of circulating IL-8 and nitric oxide levels and cytokine network in children with diabetes may be associated with cardiovascular disease in their adulthood ,
In Helicobacter pylori-colonized gastric epithelial cells, IL-17-induced IL-8 synthesis is associated with and depends at least in part on the activation of ERK 1/2 MAP kinase ,
Flagellin and SopE2 interact functionally at multiple levels to increase IL-8 secretion by Salmonella typhimurium infected enterocytes ,
cPLA2 has an influence on IL-8 and COX 2 gene and protein expression at least in part through PPAR-gamma ,
FasL induces NF-kappaB activation and IL-8 production by a novel mechanism, distinct from that of TNF-alpha ,
Serum CXCL8 and CXCL8 secretion from PBMCs are significantly higher in untreated MS patients compared to controls and are significantly reduced in MS patients receiving interferon-beta1a therapy. ,
A new model of colonic infection by Shigella utilizes a double intraluminal addition of recombinant human IL-8, together with invasive S. flexneri, to induce mucosal lesions with inflammatory infiltrate that appear similar to human bacillary dysentery. ,
association with asthma and a significant inverse distribution of the polymorphisms in juvenile idiopathic arthritis ,
the presence of the membrane-anchored, but not the soluble, form of CD14 is a strong factor in IL-8 induction in bladder epithelial cells in response to bacterial components ,
IL-8 release from cultured sinus epithelium cells was increased by lipopolysaccharide and lipoteichoic acid ,
both glucocorticoids and interferons inhibit TNF-alpha-induced upregulation of IL-8 at the mRNA level. ,
B. fragilis toxin-stimulated IL-8 secretion involves tyrosine kinase-dependent activation of nuclear factor-kappaB (NF-kappaB) as well as activation of the mitogen-activated protein kinases, p38 and extracellular signal-related kinase ,
Serum levels elevated in prostatic cancer with bone metastssis. ,
IL-8 and its receptors participate in the altered megakaryocyte growth that features myeloid metaplasia with myelofibrosis ,
expression upregulated in oral mucosa cells by Candida albicans and Streptococcus salivarius ,
IL-1-inducible phosphorylation of p65 NFkB is mediated by multiple protein kinases including IKKalpha, IKKbeta, IKKepsilon, TBK1, and an unknown kinase and couples p65 to TAFII31-mediated IL-8 transcription ,
airway fluid from mechanically ventilated premature infants contains soluble factors capable of inducing airway epithelial cell IL-8 expression via a NF-kappa B-dependent pathway, and that IL-1 beta plays a specific role in this process. ,
bacteria-derived tripeptides stimulate human PMN to release VEGF and IL-8, which activate endothelial cells and induce angiogenesis by a paracrine feedforward mechanism involving endothelial IL-8 upregulation. ,
IL-1 is a potent cytokine stimulus for IL-8 RNA stabilization in breast cancer cells. ,
hPepT1 stimulates il-8 secrretion in colonic cancer cells. ,
group IB secretory phospholipase A2 (PLA2gr1b) stimulates the expression and secretion of CXC chemokine ligand 8 in human neutrophils without affecting other proinflammatory cytokines ,
MCP-1, MIP-1beta, and IL-8 elevated in relapsing polychondritis(RP) are proinflammatory chemokines, characteristic of activation of monocytes and macrophages and, in the case of IL-8, also of neutrophils. Role for cell-mediated immune response in RP. ,
IL-8 may have a critical role in breast tumor progression ,
majority of neutrophil chemoattractant activity produced by female reproductive tract epithelial cells results from the synergistic effects of IL-8 and GM-CSF ,
we show that Ras-dependent CXCL-8 secretion is required for the initiation of tumor-associated inflammation and neovascularization. ,
CD38 is stimulated by sequential activation of IL8 receptor, IP(3)-mediated Ca(2+) rise, and cGMP/protein kinase G and plays an essential role in IL8-induced migration of LAK cells ,
IKK-beta/NF-kappa B transcription pathway is a key regulator of IL-6, IL-8, and TNF-alpha release from adipose tissue and skeletal muscle ,
IL-8 has a role in tumor microenvironment in lung cancers [review] ,
Interleukin-8 has a role in progression of cystic fibrosis ,
CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway ,
induced by Helicobacter pylori HSP60 through interaction with TLR (Toll-like receptor) in gastric epithelial cells ,
Endometrial stromal cells cultured with cyclic stretch stimulated the mRNA expression of IL-8. ,
data suggest that IL-8/CXCL8 protease resistance is due to disulfide bond-related tertiary folding ,
IL-8-induced NF-kappaB activation proceeds through a TRAF2-independent but TRAF6-dependent pathway, followed by recruitment of IRAK and activation of IKK ,
the interleukin (IL)-8 (-251) TT genotype was associated with an approximately fourfold increased risk for multiple system atrophy. ,
The IL-8 is increased of native human acute myelogenous leukemia (AML) blasts and nonleukemic cells in the bone marrow microenvironment seem important both for disease development chemosensitivity. ,
GSK3 and PKB/Akt have roles in the integrin-mediated regulation of PTHrP, IL-6 and IL-8 in pancreatic cancer ,
both estradiol and progesterone stimulated IL-8 mRNA and protein expression in endometrial cells from women with endometriosis ,
Delayed recruitment of Fra-1 to the IL-8 promoter provides an example how AP-1 subunits may dampen excessive chemokine synthesis. ,
The expression level of IL-8 mRNA was significantly increased by alpha-humulene in an intestinal epithelial tumor cell line. ,
Our results link low-grade IL-8-mediated cartilaginous inflammation in OA to altered chondrocyte differentiation and disease progression through PiT-1 expression and sodium-dependent Pi uptake mediated by CXCR1 signaling. ,
acrolein can suppress inflammatory processes in the airways by inhibiting epithelial IL-8 production through direct or indirect inhibitory effects on NFkappaB activation ,
Curcumin acts as a free radical scavenger to induce glutathione biosynthesis and inhibit NF-kappaB activation and interleukin-8 release in alveolar epithelial cells ,
IL-8 chemokine activity potentiates amyloid beta peptide (fragment 1-42)-induced microglial expression and secretion of pro-inflammatory mediators TNF-alpha, IL-1 beta, IL-6 and inflammatory enzyme cyclooxygenase-2. ,
Tumor Necrosis Factor-alpha significantly induces both IL-8 and endothelin 1 gene expression in human dermal microvascular endothelial cells possibly through different redox signaling pathways ,
Prostaglandin E2 induces interleukin-8 gene transcription by activating C/EBP homologous protein in human T lymphocytes ,
results provide a molecular cascade showing nitric oxide-Heme oxygenase(HO)-1-vascular endothelial growth factor (VEGF)-interleukin-8 sequence in human endothelial cells ,
study shows that bradykinin upregulates IL-1beta- and TNFalpha-stimulated IL-8 production via BK B2 receptor and that PKC signal pathway seems to be involved in the upregulation of the cytokine-induced IL-8 production in gingival fibroblasts ,
Extracellular catalase induces IL-8 in primary chondrocytes. ,
IL-1alpha, TNF-alpha, CCL20, CCL27, and CXCL8 alarm signals are induced in human cells after allergen and irritant exposure ,
caspase-8 plays an important role in the ASC-mediated NF-kappaB activation and IL-8 production, which actually induces physiologically relevant gene expression ,
IL-8 secretion induced by Helicobacter pylori through a dual mechanism that includes a TLR2/5-independent component involving the activities of JNK and ERK and a TLR2/5-dependent component that requires p38 activity. ,
both autocrine and paracrine regulation are involved in IL-8 expression of lung cancer cells cocultured with macrophage ,
BCG induced transcription and secretion of the chemokine CXCL8, by signalling through Toll-like receptors TLR2 and TLR4, in conjunction with myeloid differentiation factor 88 (MyD88)in neutrophils ,
cAMP-independent PKA activation and a PKC-associated pathway are probably involved in the regulation of UVB-induced IL-8 synthesis in human keratinocytes ,
Exposure of human uterine myocytes to both stretch and IL-1beta activates the MAPK system, which is responsible for the increase in il-8 mRNA expression. ,
although IL-8 dimers or monomers are sufficient for several neutrophil functions, dimers may participate in suppression of specific surface-dependent neutrophil responses ,
Significantly higher levels of IL-8 secretion by human endothelial progenitor cells (EPCs) than by mature endothelial cells. IL-8 appears to be an important mediator of the paracrine mitogenic effect of EPCs. ,
TNFalpha also increased the level and extracellular release of interleukin-8 ,
IL-8-induced MMP-9 release from neutrophils is mediated through CXCR2 and involves two distinct pathways, one involving PKC and ERK1/2 and the other involving Src-family kinases ,
upregulated in macrophages by OMP P6 of nontypeable Haemophilus influenzae ,
production stimulated by binding of H. pylori to CD74 on gastric epithelial cells ,
IL-17 particularly affects post-transcriptional regulation of IL-8 and IL-6 expression leading to enhanced IL-8 and IL-6 responses to secondary stimuli, and is only a weak proinflammatory stimulus by itself ,
Ca(2+) influx is necessary for a full induction of neutrophil priming by IL-8 ,
Macrolide-affected Toll-like receptor 4 expression from Helicobacter pylori-infected monocytes does not modify interleukin-8 production ,
Mitogen-Activated Protein Kinase Kinases signaling is essential for the induction of CXCL8 in epithelial cells in response to Mycobacterium bovis BCG ,
IL-8 is downregulated in blood neutrophils during complicated peritonitis ,
Heavy drinkers show higher IL-8 production by peripheral blood mononuclear cells and higher serum IL-8 concentrations. ,
Cytokine/thrombin-enhanced DC IL-8 expression interacts with constitutively expressed ICAM-1 in decidual endothelium to modulate neutrophil trafficking into hemorrhagic and inflamed first trimester decidua ,
that wt-p53 gene transfer inhibits IL-8 production and NF-kappaB transcription activity in cancer cells ,
Activation of the IL-8 promoter by HCV core protein was significantly decreased in biochemical responders after interferon therapy. ,
CD74 is expressed on the surface of gastric cells, and Helicobacter pylori can use this receptor as a point of attachment to gastric epithelial cells, which lead to IL-8 production. ,
the production of MCP-1 and IL-8 in vascular endothelial cells was induced by mast cell granules and amplified by tryptase ,
IL-8 and MCP-1 may contribute to the pathophysiology of adenomyosis ,
Lactocillus rhamnosus reduced TNFalpha-induced IL-8 production by affecting the NFkappaB/IkappaB pathway in Caco-2 cells. ,
IL-4 regulates TNFalpha-induced IL-8 expression at a transcriptional level and this mechanism involves STAT6 and NF-kappaB transcription factors ,
Cigarette smoke may directly cause the release of IL-8 from HASMC, an effect enhanced by TNF-alpha which is overexpressed in COPD ,
This confirms the prediction that antibodies with affinities beyond the proposed affinity ceiling can be generated in vivo. ,
In contrast, adiponectin augmented both the phagocytosis of apoptotic cells and the IL-8 production in the presence of LPS. ,
Selective induction of CXCL8 binding site on endothelial syndecan-3 in rheumatoid arthritis(RA) synovium. This site may be involved in leukocyte trafficking into RA synovial tissue. ,
IL-8 production is controlled by de novo transcriptional induction as well as posttranscriptional up-regulation of IL-8 by neonatal leukocytes, relating to the development of premature chronic lung disease ,
IL-8 is responsible for tumor progression and liver metastasis of colorectal cancer(CRC), and activation of plasminogen activator system induced by IL-8 and VEGF may play important role in progression of CRC. ,
PAR2 activation stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells ,
endothelin-1 (ET-1) induces CXCL1 and CXCL8 secretion in three human melanoma cell lines ,
Gene polymorphisms active in the EGFR pathway may be associated with the sensitivity of colorectal cancer patients to platinum-based chemotherapy. ,
It may be assumed that IL-8 plays an important role in the pathophysiology of Behcet's disease. ,
Results indicate that histidine inhibited the hydrogen peroxide- and tumor necrosis factor-alpha-induced interleukin-8 secretion at the transcriptional level in intestinal epithelial cells. ,
We observed a correlation between IL-8 mRNA expression, intratumoral microvessel count and VEGF mRNA expression levels; furthermore, an aberrant p53 status was related to IL-8 expression in patients with non-small cell lung carcinoma. ,
significantly elevated levels of MMP-8 and IL-8 but not TNF-alpha were found in chronic rhinosinusitis with nasal polyposis (CRSwNP)patients; IL-8 and MMP-8 seemingly form an inductive cytokine-proteinase cascade in CRSwNP pathogenesis ,
These studies suggest that HCV core protein can lead to enhanced p38- and gC1qR-dependent IL-8 expression ,
The IL-8 -251T allele is significantly associated with increased risk of gastric carcinoma, particularly the diffuse and mixed types in Chinese population. ,
IL-8 protects liver cells from Gal/ET-mediated apoptosis by signaling through phosphatidylinositol-3 kinase (PI-3K). ,
Our results indicate that integration of adenoviral DNA and expression of E1A and E1B can either increase or decrease IL-8 production. ,
Human perivascular white adipose tissue has chemotactic properties through the secretion of chemokines ,
Significant association of interleukin 8 -251T/A polymorphism with smoking behavior in a Japanese population. ,
an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in human bronchial epithelial cells. ,
Basal secretion of IL-8 and MCP-1 was not changed in CTGF-silenced renal cells. ,
Under certain circumstances IL-8 may serve an anti-inflammatory role and thereby contribute to the resolution of tissue injury. ,
the effect of interleukin-8 (IL-8) induced by H. pylori infection on EGFR transactivation and epithelial cell growth ,
the capacity of LDLs to induce fibroblast spreading and accelerate wound closure relies on their ability to stimulate IL-8 secretion in a p38 MAPK-dependent manner ,
thrombin-enhanced IL-8 expression in term decidual cells may explain how abruption-associated premature rupture of the fetal membranes promotes decidual neutrophil infiltration ,
By upregulating IL-8, the RANKL/RANK system may contribute to the pathogenesis of B chronic lymphocytic leukemia. ,
Homozygous familial hypercholesterolemia patients exhibited significantly elevated level of active IL-8. ,
circulating neutrophils are susceptible to augmentation by IL-8 through the reinforcement of IL-8 receptors in acute inflammatory conditions ,
Der p 1 (but not Der p 3)-induced IL-8 production in A549 epithelial cells is independent of PAR(2) activation ,
The role of TLR3 in the immunobiology of muscle is reported; its implications for the understanding of the pathogenesis of inflammatory myopathies or therapeutic interventions are included. ,
results suggest that S. pneumoniae activate human epithelial cells by TLR1/2 and a phosphatidylinositol 3-kinase- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter. ,
P2Y receptors revealed that the P2Y6 (ligand of UDP) signaling pathway plays a predominant role in mediating human neutrophil peptides-induced IL-8 production. ,
Robust neutrophil chemorepulsion in gradients of IL-8 was dependent on the absolute concentration of CXCR2, and was associated with polarization of cytoskeletal elements and signaling molecules involved in chemotaxis and leading edge formation. ,
Zn(2+)-induced inhibition of phosphatase activity initiates AP-1 activation that leads to enhanced IL-8 expression by human airway epithelial cells. ,
CXCL-8 was found to partly cofractionate with calnexin, a marker for endoplasmic reticulum (ER). Thus, part of CXCL-8 may be localized to the ER or ER-like structures in the neutrophil. ,
ONOO- -dependent activation of NF-kappaB and c-Fos as an important mechanism that mediates PMN responses, including IL-8 gene expression and release, to bacterial DNA ,
The CXCL8-induced phosphorylation of FAK in CXCR1-expressing cells required cytoskeletal elements.CXCL8-induced migration was highly reliant on actin filaments, but only the migration of CXCR1-expressing cells was fully dependent on microtubules. ,
Histamine stimulated the activation of MAPK signals, which may regulate the expression or IL-8 and GM-CSF ,
PAR2-driven upregulation of VCAM-1 cell surface expression and the release of IL-8 and G-CSF from bronchial fibroblasts may be important in promoting neutrophilic airways inflammation. ,
Findings indicate that IL-8 mRNA translation and degradation are affected by the distortion of the cytoskeleton in airway epithelial cells. ,
IL-8 has an effect on the pancreatic cancer cells in an autocrine manner. ,
TGF-beta1 signaling regulates IL-8 expression in prostate cancer cells and may contribute to the overexpression of IL-8 in human prostate cancer. ,
findings indicate thathuman gingival epithelial cells synthesize increased levels of IL-1alpha and IL-8 in response to viable Candida albicans before cell injury is manifested ,
non-Afa/Dr DAEC (diffusely adherent E. coli) can induce IL-8 in epithelial cells (HEp-2, INT407, and T84). ,
IL-6 and IL-8 production by human articular chondrocytes is vitro are stimulated by histamine exposure, this being mediated bia the H1R pathway ,
IL-6 and IL-8 are associated with postoperative surgical site infection, including pancreatic leakage after pancreaticoduodenectomy. ,
our results strongly suggest that ghrelin may be a proinflammatory peptide in the colon. Ghrelin may participate in the pathophysiology of colonic inflammation by inducing PKC-dependent NF-kappaB activation and IL-8 production at the colonocyte level ,
Results suggest that, in human myocardial infarction, IL-8 produced by neutrophils is responsible for the subsequent accumulation and activation of neutrophils, thus increasing the degree of myocardial damage. ,
Furthermore, hyaluronan, by inducing IL-8 and IP-10 by distinct pathways, provides a unique target for differential regulation of key inflammatory chemokines. ,
Human monocytes readily produce IL-8 upon cigarette smoke stimulation. IL-8 production is dependent on Toll-like receptor 4 stimulation. ,
We conclude that NE increases IL-8 transcription through p38/NF-kappaB activation via EGFR transactivation. ,
Patients who had a combined BM relapse had lower IL-8 and CXCR4 expression than those who had an isolated BM relapse om chldhood acute lymphoblastic leukemia. ,
lysophosphatidic acid-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF ,
The biological interaction networks of the SqCC profile identified IL-8 as playing a potentially important role SqCC development ,
Further analyses show that inhibitors of phosholipase D, Rho, and protein kinase C also inhibited the LPL-induced release of IL-6 and IL-8. ,
ASC expression correlates with IL-8 secretion and may play an important role in maintaining mucosal homeostasis ,
Carriers of IL-8 -251 T allele may have increased susceptibility to multiple sclerosis because of their differences in neuron survival or increased chances of viral persistence compared to carriers of A allele. ,
Elevated urine IL-8 level in kidney transplant patients with asymptomatic bacteriuria may reflect impaired immune response to bacterial infection and occult inflammatory process in urinary tract ,
These results suggest that lysophospholipid released by activated platelets might enhance the IL-8- and MCP-1-dependent chemoattraction of monocytes toward the endothelium through an IL-1-dependent mechanism. ,
Real-time RT-PCR confirmed up-regulation of IL-8, osteopontin, and TNFRSF14 and down-regulation of SAMeS and CD209 in AH. ,
IL-8 is induced from human neutrophils by tryptic enzymes via proteinase activated receptor-2 ,
MSI-H GC is associated with IL-8-251 T/T (low expression genotype) and is inversely correlated with cigarette smoking. ,
Elevated systemic levels of the chemokines MCP-1, IL-8, and IP-10 precede coronary heart disease but do not represent independent risk factors. ,
Stimulation of interleukin (IL)-8 expression by IGF-I is through the formation of activator protein-1 complex. ,
M. bovis BCG-infected human epithelial cells can have an active role in a local inflammatory immune response via the secretion of IL-4, CXCL-8 and CXCL-10, which can be selectively regulated by Th2-derived cytokines ,
IL-8 and IL-6 may have roles in development of psoriasis ,
The data indicate that in the replicon system, CXCL-8 protein levels are positively associated with chronic HCV replication and that CXCL-8 removal inhibits HCV replication. ,
These studies indicate that adenovirus 7 (Ad7) internalization is calcium-dependent and is required for IL-8 protein induction upon Ad7 infection. ,
Infection of human endothelial cells by B. henselae resulting in IL-8 production likely plays a central role in the ability of this organism to cause angiogenesis during infection. ,
post-ischemic modulation of IL-8 release and synthesis following ischemia reperfusion will require strategies directed towards inhibition of IL-8 transcription ,
PKD2 is involved in the production of IL-8, a potent proinflammatory chemokine, by epithelial cells. ,
the human IL-8 -251 A/T polymorphism and the polymorphisms in H pylori vacA gene are involved in limiting the infection outcome to gastritis and peptic ulcer or in favoring cancer onset in Iranian patients ,
Adiponectin-mediated induction of IL-6, CCL2 and CXCL8 is disturbed in monocytes from type I diabetes patients. ,
Activated hydrolase-secreting macrophages in atherosclerotic lesions may sustain proatherogenic extracellular environment by hydrolyzing LDL and triggering it to act in autocrine or paracrine fashion to induce IL-8 secretion by plaque macrophages. ,
Data show that the gene expression for interleukin-8, IL-10, and IL-1Ra, but not IL-6, is increased in blood leukocytes taken from athletes following 2 hours of intensive cycling and is not influenced by carbohydrate compared with placebo ingestion. ,
analysis of the LLKIL motif in CXCR2, which is required for full IL-8 ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells ,
Hierarchical regression analyses revealed a positive relationship between production of IL-8 and symptoms of depression, trait negative affect, and perceived stress. There was an inverse relationship between IL-8 production and perceived social support. ,
C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production ,
distribution results may help define the true significance of IL8 -251 A>T polymorphism as a marker for smoking behavior in populations worldwide ,
Pc-mediated IL-8 release by human AM requires the coexpression of MR and TLR2 and further supports the concept that combinatorial interactions of macrophage innate receptors provide specificity of host defense cell responses to infectious challenge. ,
LDL lipoprotein subunit L5 induces human umbilical vein endothelial cells (HUVEC) to express IL-8. ,
[Bpa(74)]hIL-8 has a high tendency to form covalent dimers whereas no dimer formation was observed for the variant with Bpa at position 65. ,
HCV infection triggers dsRNA signaling pathways that induce CXCL-8 via transcriptional activation. ,
macrolides (but not steroids/immunosuppressive agents) inhibit IL17-induced IL8 production in human primary airway smooth muscle cells via a reduction in MAPK activation and 8-isoprostane production. ,
results implicate involvement of toll-like receptors, particularly TLR7, and type 1 specific interferon signaling in the pathogenesis of BA, especially in early stage, which is associated with upregulation of inflammatory cytokines IL-8 ,
These results suggest that the COX-2-PGE(2) pathway may be involved in IL-8 production in gastric epithelial cells. ,
There were no statistically significant differences in IL-6 and IL-8 gene polymorphisms between the SLE and control groups (chi-squared test, P=0.53, chi(2)=1.27 and P=0.44, chi(2)=1.62, respectively). ,
These findings show that melanoma cells induce PMNs to secrete IL-8 through activation of NF-kappaB and suggest a model in which this interaction promotes a microenvironment that is favorable for metastasis. ,
findings of this study suggest that the mutant allele of the (-251 A/T) polymorphism may be a major contributing genetic factor to risk for oral cancer ,
MAPK and PI3K pathways regulate the synergy of IL-17 and IL-1beta to enhance CXCL-8 promoter activity, mRNA induction, and protein synthesis in human airway smooth muscle cells via the cooperative activation of AP-1 and NF-kappaB trans-acting elements. ,
TNF-alpha enhanced TLR ligand-induced IL-8 production in human gingival fibroblasts ,
esophageal inflammation may be induced by protease-activated receptor 2 activation via reflux of trypsin ,
data herein indicate that the second extracellular loop (2ECL) of the receptors CXCR1,CXCR2, and CXCL8 is critical for the distinct rate of internalization of each ,
the differential regulation of expression by PKCalpha/beta in lung adenocarcinoma cells ,
data indicate that IL-8 gene is not involved in the pathogenesis of familial vesico-ureteral reflux or reflux nephropathy ,
HNP enhanced the interaction between A549 cells and CD4+ lymphocytes by increasing cell adhesion and release of IFN-gamma, IL-2, and IL-8. This was attenuated by using an alpha1-proteinase inhibitor to neutralize HNP. ,
A signaling pathwayon the surface of airway epithelial cells that mediates airway epithelial defense against bacterial infection by producing IL-8. ,
Results demonstrate that IL-8 production may be augmented upon the malignant transformation of hepatocytes in chronic hepatitis C. ,
results suggest that ERK and p38 MAPK signalling linked to the TLR2 recognition receptor in human monocytes may be an important pathway in H. pylori-HSP60-induced IL-8 secretion ,
These results suggest that the genetic polymorphisms of proinflammatory chemokine IL-8 can contribute to the pathogenesis of Behcet's disease. ,
HDM-induced IL-8 production is predominantly regulated by Ca(2+)/calmodulin signaling, and ERK plays an important role in signal transmission for efficient activation of the HDM-induced IL-8 signaling pathway. ,
NTAL acts as a negative regulator of TNF-alpha and IL-8 production after stimulation via TREM-1. ,
Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8, interleukin-1beta, tumor necrosis factor-alpha, and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like receptor 4 ,
activation of the prostanoid DP receptor on THP-1 cells enhances TNF-alpha-induced MCP-1 and IL-8 production via the cAMP/PKA signaling pathway ,
The -251 IL-8 polymorphism was significantly associated with either gastritis or duodenal ulcer in H. pylori-infected subjects. ,
The researchers found a decreased risk of laryngeal cancer when a polymorphism occurs in the minor allele A promoter ,
Understanding of the cross-talk between NF-kappaB and MAPKs signaling in CF lung epithelial cells may help in developing new therapeutics to reduce lung inflammation in patients with CF. ,
The use of Cu(+)/Cu(2+)-binding peptides might be beneficial in the treatment of ROS-related diseases associated with copper. ,
Psychosine does not modifiy IL-8 production by peripheral immune cells of Krabbe patients. ,
Inhibition of ERK phosphorylation decreased expfression of IL8. ,
These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of bronchiolitis obliterans after measles virus infection. ,
Neutrophilic infiltration around reactive bile ductules may be related to the IL-8 expressed in bile ductular epithelia. ,
link between IL-8-251A allele & increased posttraumatic ARDS. reaffirms central role of IL-8 in pathogenesis of ARDS & points towards genetic predisposition for posttraumatic IL-8 synthesis which might be associated with posttraumatic ARDS. ,
IGF-I stimulates IL-8 expression in a prostatic cancer cell line. ,
anti-IL-8 ,
presence of intracellular HCV antigens led to transcriptional and protein expression of IL-8 (CXCL-8), and impaired interferon induction of signal transducers and activators of transcription 1 (STAT1) serine and tyrosine and STAT2 tyrosine phosphorylation ,
Identify Bcl10 as a mediator of LPS-induced activation of NK-kappaB and IL-8. ,
Higher levels of IL-10, IL-8 and TNF-alpha were found in fibromyalgia patients than in controls. ,
Rapid withdrawal of inhaled corticosteroids results in an exacerbation of asthma that is preceded by an increase in sputum neutrophils and IL-8 concentrations. ,
These results suggest that E1Blarge interacts with NF-kappaB to prevent transcription and down regulate proinflammatory cytokine IL-8 production. ,
PAR-2 plays a role in serine protease-mediated regulation of IL-8 and GRO-alpha in nasal epithelial cells and may be involved in the pathophysiology of rhinosinusitis. ,
The PRBC group had a significantly different expression profile included up-regulation of the interleukin-8. PRBCs activate inflammatory genes in circulating leukocytes. ,
host susceptibility to C. difficile diarrhea is related both to a defective humoral immune response to CD toxin A and host IL-8 AA genotype. ,
UVB enhances melanoma cell motility and that this effect is mediated at least in part by IL-8 released by melanoma cells in an autocrine fashion ,
complex roles of IL-8 in the regulation of estrogen receptor-negative breast cancer progression may in part be related to its potent chemotactic effects on neutrophils ,
Fibrinogen alone and fibrinogen plus C5a are potent inducers of IL-8 production in monocytes, and signaling by fibrinogen is mediated through the TLR-4 pathway. ,
The N-loop residues in IL-8 (H18 and F21) and the receptor N-termini are the major structural determinants regulating the rate of receptor internalization, which in turn controlls the activation profile of ERK1/2. ,
IL-8 is a molecular determinant of androgen-independent prostate cancer growth and progression ,
Azithromycin suppressed NF-kappaB activation and reduced synthesis of IL6/IL8 in tracheal cells from preterm ventilated infants. ,
interleukin-8 (CXCL-8) is induced by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells ,
Knockdown of Embryonic development associated gene (EDAG), expression by siRNA is associated with decreased expression of IL-8. ,
These data demonstrate for the first time that lipid accumulation in hepatocytes can stimulate IL-8 production, thereby potentially contributing to hepatic inflammation and consequent liver injury. ,
Cervical IL-6 and IL-8 might have predictive value for cases of recurrent miscarriage. ,
Results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. ,
Promoter polymorphism is associated with increased nasopharyngeal carcinoma risk, particularly in males, as well as disease progress. ,
17beta-estradiol (E2) attenuates lipopolysaccharide-induced expression of CXCL8 in human peripheral blood monocytes ,
CHROMOSOME
4,
ENTREZ_GENE_ID
3576 ,
PIR_SUMMARY
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.,
UNIGENE
Hs.551925 ,
Hs.561078 ,
Hs.624 ,
PIR_NREF_ID
NF00154197,
UNIREF100_ID
UniRef100_P10145 ,
CYTOBAND
4q13-q21,
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