UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

SANTA Dm.nm.4 SANTA cnuz

SCHOOL OP MEDICINE SAN FIWNCISCO, CALIE'OIINIA 941 22

Febuary 3, 1976

Dr. Dominique Stehelin
I.R.S.C.
B. P. - 8
94800-Ville juif
France

Dear Dominique :

Many thanks for your letter of December 10, which, believe it or not, arrived
in late January.
But no clear cut pattern that would suggest a simple role for the sarc gene in
normal cells has yet emerged from Daisy and Debbie's survey of cultured cells
or from Tom's survey of embryos.  Sarc is simply turned on everywhere, with up
to 5-fold differences among some of the samples. (Happily, globin and ovalbumin
are completely off in the embryo cultures we've tested.  So the turn-on is not
global.)  I will have to summarize some of this stuff for a Squaw Valley manu-
script, and will consult with you at that time.
it does appear that sarc and RAV-0 are unlinked in normal cells, since sarc is
in macros.

We are all happy to hear that our results are all in agreement.

If I didn't mention it before,

I'm glad to hear you're able to retain your American work ethic in the face of
French mores, and that your family is doing well.

Best regards,

Harold E. Varmus, M. D.
Associate Professor
Department of Microbiology

HEV/es