Building 38A, 8th floor conference room at 11 am Friday January 14th, 2000. Speaker: Sanguthevar Rajasekaran, University of Florida, Gainesville. Department of Computer, Information Science and Engineering. Title: Local Alignment Search in Biological Sequences Abstract: We present efficient algorithms for local alignment seaches in biological sequences. These algorithms identify maximal segment pairs (MSPs). Our algorithms are efficiently parallelizable. We employ fast Fourier transforms (FFTs). Though several attempts have been made in the past to employ FFTs in sequence analysis, they fail to capture local similarities. Our algorithms employ FFTs in a novel way to identify local similarities. FFT-based techniques have the attractive feature of benefiting from ultrafast special purpose hardware available for digital signal processing. We also present a sorting based algorithm and a suffix tree based algorithm for the same problem.