Weniger BG, Tansuphaswadikul S, Young NL, Pau CP, Lohsomboon P, Yindeeyoungyeon W, Limpakarnjanarat K; National Conference on Human Retroviruses and Related Infections.
Program Abstr First Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 1st 1993 Wash DC. 1993 Dec 12-16; 105.
Division of HIV/AIDS, CDC, Atlanta, GA.
Introduction: Comparison of clinical features of the two major, distinct HIV-1 genotypes in Thailand--AA and B--is made possible by peptide EIA serotyping which, if monoreactive, has 100% PVP for the true genotype. Methods: HIV+ outpatients (n=60) and inpatients (n=267) admitted 8/91-9/92 were serotyped, resulting in 216 type As and 73 type Bs for analysis (12 dual-reactors and 26 nonreactors were excluded). Results: Of 162 sexual risk-group patients, 99% (160) had HIV-1 type A, while 86% (66) of 77 IDUs had B. Type As had lower mean CD4+ levels (204/microliter, 11.4%) than Bs (310/microliter, 20.0%, p less than .001), with similar trend when stratified by sex and transmission mode. CD4+ levels less than 200/microliter or less than 14% occurred in 64% (133/209) of As and 44% (31/71) of Bs (p=.003). All 17 Pneumocystis diagnoses were in As (p less than .01), as were all 34 non-Candida mycoses (p less than .001), including two of Penicillium marneffei. However, TB occurred in fewer As (33%) than Bs (53%, p=.002). Inpatient fatality rate was 20% for A and 12% for B (p=.14). Conclusion: Thai HIV-1 types segregate markedly by transmission mode. Lower CD4+ levels and different opportunistic infections in type A vs. B may result from confounding or perhaps from real biological differences.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Antigens, CD4
- Genotype
- HIV
- HIV Envelope Protein gp120
- HIV Infections
- HIV Seronegativity
- HIV Seropositivity
- HIV Seroprevalence
- HIV-1
- Health Personnel
- Humans
- Serotyping
- Thailand
- genetics
- immunology
Other ID:
UI: 102214244
From Meeting Abstracts