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Blood Protein Warns of Hidden Belly Fat
and Disease Risk
People with excess deep-belly fat are known to be at increased
risk for cardiovascular disease and type 2 diabetes. Now scientists
have found that this type of fat, compared to other types, produces
higher levels of a protein that can be detected in the blood. The
protein may serve as a simple indicator for deep visceral fat and
disease risk.
In recent years scientists at Beth Israel Deaconess Medical Center
and Harvard Medical School in Boston have been exploring the unexpected
complexity of the molecule retinol-binding protein (RBP4), once
thought to have the sole purpose of ferrying vitamin A (retinol)
through the bloodstream. The researchers, led by Dr. Barbara B.
Kahn, showed that it appears to affect insulin resistance, a risk
factor for diabetes, in mice. In people, RBP4 is elevated in obese
or diabetic individuals with insulin resistance, and it drops with
exercise training or other interventions known to reverse insulin
resistance.
In the new study, reported in the July 2007 issue of the journal Cell
Metabolism, the scientists set out to determine if blood
levels of RBP4 were directly influenced by visceral fat, which
surrounds abdominal organs and has been linked to disease risk.
They measured blood levels of RBP4 in 130 obese and 66 lean people.
Each participant underwent a computed tomography (CT) scan to
assess relative amounts of visceral fat and subcutaneous fat,
which lies just beneath the skin. The researchers also analyzed
RBP4 gene expression in small samples of both visceral and subcutaneous
fat from each person. The study was funded in part by NIH's National
Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
The scientists found that, overall, RBP4 gene expression was 5-fold
higher in visceral than in subcutaneous fat. In obese people with
a "visceral fat" pattern of obesity, RBP4 gene expression
in visceral fat cells was 60-fold higher than in the lean group.
By comparison, RBP4 expression increased just 12-fold in people
with a "subcutaneous fat" pattern.
Blood levels of RBP4 measured up to 3 times higher in obese than
in lean people. Those with higher blood levels of RBP4 had a corresponding
increase in abdominal fat and a reduction in insulin sensitivity,
regardless of their age, gender or body mass index (a ratio of
weight to height).
Among several fat-secreted proteins now associated with insulin
activity, blood concentration of RBP4 is thus far the strongest
predictor of a person's visceral fat load and insulin resistance.
With further study, RBP4 may serve as a convenient marker to identify
patients at risk for type 2 diabetes and cardiovascular disease.
—by Vicki Contie
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