DAVID Gene Report
43771
early b-cell factor 1 Related Genes Mus musculus
SP_COMMENT
developmental stage:First detected at 9.5 dpc.,
function:Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.,
similarity:Belongs to the COE family.,
similarity:Contains 1 IPT/TIG domain.,
subcellular location:Nucleus .,
subunit:Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes (By similarity). Forms either a homodimer or a heterodimer with a related family member.,
tissue specificity:Expressed at high levels in early B-cells, spleen, lymph node and adipose tissue, and at low levels in heart, brain, skeletal muscle and kidney. In adult expressed in olfactory epithelium, in spleen, and at a lesser extent in Purkinje cells of the cerebellum, heart, kidney, lung, thymus and testis. In embryo expressed in dorsal thalamus and epithalamus, at a lower level in mesencephalon and in the caudal rhombencephalon, in the postmitotic cells of developing retina, highly in developing spinal cord, dorsal root ganglia, trigeminal ganglia and in glossopharyngeal nerve ganglia, in developing inner ear.,
REFSEQ_PROTEIN
NP_031923 ,
REFSEQ_MRNA
NM_007897 ,
GENPEPT_ACCESSION
AAA37533 ,
BAC27313 ,
BAC29185 ,
BAC31407 ,
BAE23864 ,
BAE24573 ,
BAE43347 ,
CAI23921 ,
CAI23922 ,
CAI23923 ,
CAI24864 ,
CAI24865 ,
CAI24866 ,
CAI25206 ,
CAI25207 ,
CAI25208 ,
EDL33837 ,
EDL33838 ,
EDL33839 ,
Genomic_DNA ,
JOINED ,
mRNA ,
GENE_SYMBOL
EBF1 ,
GENE_NAME
0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230085D05 product:early B-cell factor 1, full insert sequence,
12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone: D130048P03 product: early B-cell factor, full insert sequence,
12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130048P03 product:early B-cell factor, full insert sequence,
13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930435O04 product:early B-cell factor, full insert sequence,
16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630004C21 product:early B-cell factor, full insert sequence.,
7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730040I05 product:hypothetical protein, full insert sequence,
Adult male aorta and vein cDNA, RIKEN full-length enriched library, clone: A530079D01 product: early B-cell factor 1, full insert sequence,
Adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530079D01 product:early B-cell factor 1, full insert sequence,
Early B-cell factor,
Early B-cell factor 1 (0 day neonate cerebellum cDNA, RIKEN full- length enriched library, clone: C230085D05 product: early B-cell factor 1, full insert sequence),
O/E-1,
OE-1,
Transcription factor COE1,
Transcription factor COE1 (OE-1) (O/E-1) (Early B-cell factor),
early B-cell factor 1,
GENERIF_SUMMARY
Characterization of a promoter flanking the early B cell factor (Ebf) gene indicates roles for E-proteins and autoregulation in the control of Ebf expression. ,
data point to the importance of O/E target genes for adipocyte differentiation and suggest a novel role for O/E-1 as an initiator and stimulator of adipogenesis ,
Oscillation between B-lymphoid and myeloid lineages was seen in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway. ,
EBF1 has a role in determining that a set of thalamic axons reaches the neocortex in developing mice ,
high levels of E2A protein activity are essential for the activation of EBF and N-myc. ,
Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. ,
We demonstrate that Ebf1 is a lineage-specific transcription factor essential to the differentiation of striatonigral neurons. ,
the protein causing the pre-B cell-specific in vivo footprint on a sequence similar to the EBF-binding consensus is truly EBF as judged by EMSA using various oligo-DNA competitors and anti-EBF antibodies ,
Reduction of Ebf1 and Ebf2 proteins by specific short hairpin RNA blocks differentiation of 3T3-L1 cells, suggesting a critical role for these factors and the absence of functional redundancy between members of this family. ,
The regulation of Ebf1 via distinct promoters allows for the generation of several feedback loops and the coordination of multiple determinants of B lymphopoiesis in a regulatory network. ,
Ebf1 expression is maintained abnormally in cerebellar ventricular zone of Zfp423-deficient mice. ,
CHROMOSOME
11,
ENTREZ_GENE_ID
13591 ,
PIR_SUMMARY
Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.,
UNIGENE
Mm.439662 ,
Mm.440346 ,
PIR_NREF_ID
NF00522166,
NF01175453,
NF01179586,
NF01179760,
NF02197022,
NF02197635,
NF02864789,
NF02869597,
UNIREF100_ID
UniRef100_Q3UTW6 ,
UniRef100_Q3V317 ,
UniRef100_Q5SRG7 ,
UniRef100_Q63398 ,
UniRef100_Q9UH73 ,
UNIPROT_ID
COE1_MOUSE ,
Q3UTW6_MOUSE ,
Q3V317_MOUSE ,
Q5SRG6_MOUSE ,
Q5SRG7_MOUSE ,
Q5SRG8_MOUSE ,
Q8BSM3_MOUSE ,
Q8C955_MOUSE ,
Q8CBL7_MOUSE ,
CYTOBAND
11 20.0 cM,
11 B1.1,
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