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Title Localization of mercury in CNS of the rat. I. Mercuric chloride (HgCl/sub 2/) per os
Creator/Author Moeller-Madsen, B. ; Danscher, G.
Publication Date1986 Oct 01
OSTI IdentifierOSTI ID: 5089386
Other Number(s)CODEN: ENVRA
Resource TypeJournal Article
Resource RelationEnviron. Res. ; Vol/Issue: 41:1
Research OrgUniv. of Aarhus, Denmark
Subject560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987); MERCURY-- BIOLOGICAL LOCALIZATION;MERCURY-- TISSUE DISTRIBUTION; CENTRAL NERVOUS SYSTEM;CHRONIC INTAKE;DRINKING WATER;EXPERIMENTAL DATA;MERCURY CHLORIDES;RATS
Related SubjectANIMALS;CHLORIDES;CHLORINE COMPOUNDS;DATA;DISTRIBUTION;ELEMENTS;HALIDES;HALOGEN COMPOUNDS;HYDROGEN COMPOUNDS;INFORMATION;INTAKE;MAMMALS;MERCURY COMPOUNDS;MERCURY HALIDES;METALS;NERVOUS SYSTEM;NUMERICAL DATA;OXYGEN COMPOUNDS;RODENTS;VERTEBRATES;WATER
Description/Abstract Adult Wistar rats of both sexes were exposed to mercuric chloride (HgCl/sub 2/) through drinking water (20 mg HgCl/sub 2/ liter/sup -1/ distilled water) ad libitum during an 8-month period.^Animals were subsequently sacrificed by transcardial perfusion with glutaraldehyde.^Coronal sections of the brain and cervical spinal cord were examined according to a histochemical technique based on a physical development process which renders mercury deposits visible.^Mercury was found unevenly distributed in the brain and spinal cord with the heaviest deposits found within the motor nuclei of the rhombencephalon.^In cerebral cortex, the highest concentration of mercury was found in the striate area.^Mercury was also localized within the deep nuclei of cerebellum; none was found within Purkinje cells.^A proportionately high amount of mercury was additionally found in the anterior horn motoneurons of the spinal cord.^In general, mercury was found primarily within neurons, but it was also observed in the cytoplasm of glia and ependymal cells.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 29-43
System Entry Date2001 May 13

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