Our Science – Choyke Website

Peter L. Choyke, M.D.

Selected Publications

1) Regino CA, Walbridge S, Bernardo M, Wong KJ, Johnson D, Lonser R, Oldfield EH, Choyke PL, Brechbiel MW.
A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents.
Contrast media & molecular imaging. 3: 2-8, 2008. [Journal]

2) Longmire MR, Ogawa M, Hama Y, Kosaka N, Regino CA, Choyke PL, Kobayashi H.
Determination of optimal rhodamine fluorophore for in vivo optical imaging.
Bioconjug. Chem. 19: 1735-42, 2008. [Journal]

3) Singh AK, Kruecker J, Xu S, Glossop N, Guion P, Ullman K, Choyke PL, Wood BJ.
Initial clinical experience with real-time transrectal ultrasonography-magnetic resonance imaging fusion-guided prostate biopsy.
BJU Int. 101: 841-5, 2008. [Journal]

4) Giesel FL, Choyke PL, Mehndiratta A, Zechmann CM, von Tengg-Kobligk H, Kayser K, Bischoff H, Hintze C, Delorme S, Weber MA, Essig M, Kauczor HU, Knopp MV.
Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34).
Academic radiology. 15: 563-70, 2008. [Journal]

5) Choyke PL.
Radiologic evaluation of hematuria: guidelines from the American College of Radiology's appropriateness criteria.
American family physician. 78: 347-52, 2008. [Journal]

6) Bratslavsky G, Liu JJ, Johnson AD, Sudarshan S, Choyke PL, Linehan WM, Pinto PA.
Salvage partial nephrectomy for hereditary renal cancer: feasibility and outcomes.
J. Urol. 179: 67-70, 2008. [Journal]

7) Koyama Y, Talanov VS, Bernardo M, Hama Y, Regino CA, Brechbiel MW, Choyke PL, Kobayashi H.
A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice.
Journal of magnetic resonance imaging : JMRI. 25: 866-71, 2007. [Journal]

8) Mai PL, Korde L, Kramer J, Peters J, Mueller CM, Pfeiffer S, Stratakis CA, Pinto PA, Bratslavsky G, Merino M, Choyke P, Linehan WM, Greene MH.
A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report.
Journal of medical case reports. 1: 9, 2007. [Journal]

9) Hama Y, Urano Y, Koyama Y, Gunn AJ, Choyke PL, Kobayashi H.
A self-quenched galactosamine-serum albumin-rhodamineX conjugate: a.
Clin. Cancer Res. 13: 6335-43, 2007. [Journal]

10) Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Shin IS, Paik CH, Choyke PL, Kobayashi H.
A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate.
Cancer Res. 67: 2791-9, 2007. [Journal]

11) Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
Activatable Fluorescent Molecular Imaging of Peritoneal Metastases following Pretargeting with a Biotinylated Monoclonal Antibody.
Cancer Res. 67: 3809-17, 2007. [Journal]

12) Kamiya M, Kobayashi H, Hama Y, Koyama Y, Bernardo M, Nagano T, Choyke PL, Urano Y.
An enzymatically activated fluorescence probe for targeted tumor imaging.
J. Am. Chem. Soc. 129: 3918-29, 2007. [Journal]

13) Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M.
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Proc. Natl. Acad. Sci. U.S.A. 104: 8749-54, 2007. [Journal]

14) Blansfield JA, Choyke L, Morita SY, Choyke PL, Pingpank JF, Alexander HR, Seidel G, Shutack Y, Yuldasheva N, Eugeni M, Bartlett DL, Glenn GM, Middelton L, Linehan WM, Libutti SK.
Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine neoplasms (PNETs).
Surgery. 142: 814-8; discussion 818.e1-2, 2007. [Journal]

15) de Souza LR, Goldman SM, Faintuch S, Faria JF, Bekhor D, Tiferes DA, Ortiz V, Choyke P, Szejnfeld J.
Comparison between ultrasound and noncontrast helical computed tomography for identification of acute ureterolithiasis in a teaching hospital setting.
São Paulo medical journal = Revista paulista de medicina. 125: 102-7, 2007. [Journal]

16) Xu H, Baidoo K, Gunn AJ, Boswell CA, Milenic DE, Choyke PL, Brechbiel MW.
Design, Synthesis, and Characterization of a Dual Modality Positron Emission Tomography and Fluorescence Imaging Agent for Monoclonal Antibody Tumor-Targeted Imaging.
J Med Chem. 2007. [Journal]

17) Ocak I, Bernardo M, Metzger G, Barrett T, Pinto P, Albert PS, Choyke PL.
Dynamic contrast-enhanced MRI of prostate cancer at 3 T: a study of pharmacokinetic parameters.
AJR. American journal of roentgenology. 189: 849, 2007. [Journal]

18) Zbar B, Glenn G, Merino M, Middelton L, Peterson J, Toro J, Coleman J, Pinto P, Schmidt LS, Choyke P, Linehan WM.
Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development.
J. Urol. 177: 461-5; discussion 465, 2007. [Journal]

19) Roberts JN, Buck CB, Thompson CD, Kines R, Bernardo M, Choyke PL, Lowy DR, Schiller JT.
Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan.
Nat. Med. 13: 857-61, 2007. [Journal]

20) Hussain N, Feld JJ, Kleiner DE, Hoofnagle JH, Garcia-Eulate R, Ahlawat S, Koziel DE, Anderson V, Hilligoss D, Choyke P, Gallin JI, Liang TJ, Malech HL, Holland SM, Heller T.
Hepatic abnormalities in patients with chronic granulomatous disease.
Hepatology. 45: 675-83, 2007. [Journal]

21) Grubb RL, Franks ME, Toro J, Middelton L, Choyke L, Fowler S, Torres-Cabala C, Glenn GM, Choyke P, Merino MJ, Zbar B, Pinto PA, Srinivasan R, Coleman JA, Linehan WM.
Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer.
J. Urol. 177: 2074-9; discussion 2079-80, 2007. [Journal]

22) Linehan WM, Pinto PA, Srinivasan R, Merino M, Choyke P, Choyke L, Coleman J, Toro J, Glenn G, Vocke C, Zbar B, Schmidt LS, Bottaro D, Neckers L.
Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics.
Clin. Cancer Res. 13: 671s-679s, 2007. [Journal]

23) Hricak H, Choyke PL, Eberhardt SC, Leibel SA, Scardino PT.
Imaging prostate cancer: a multidisciplinary perspective.
Radiology. 243: 28-53, 2007. [Journal]

24) Barrett T, Koyama Y, Hama Y, Ravizzini G, Shin IS, Jang BS, Paik CH, Urano Y, Choyke PL, Kobayashi H.
In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies.
Clin. Cancer Res. 13: 6639-48, 2007. [Journal]

25) Koyama Y, Barrett T, Hama Y, Ravizzini G, Choyke PL, Kobayashi H.
In vivo molecular imaging to diagnose and subtype tumors through receptor-targeted optically labeled monoclonal antibodies.
Neoplasia. 9: 1021-9, 2007. [Journal]

26) Thukral A, Thomasson DM, Chow CK, Eulate R, Wedam SB, Gupta SN, Wise BJ, Steinberg SM, Liewehr DJ, Choyke PL, Swain SM.
Inflammatory Breast Cancer: Dynamic Contrast-enhanced MR in Patients Receiving Bevacizumab Initial Experience.
Radiology. 244: 727-35, 2007. [Journal]

27) Choyke PL.
Is it possible to quantify fluorescence during optical endoscopy?.
Radiology. 245: 307-8, 2007. [Journal]

28) Toro JR, Pautler SE, Stewart L, Glenn GM, Weinreich M, Toure O, Wei MH, Schmidt LS, Davis L, Zbar B, Choyke P, Steinberg SM, Nguyen DM, Linehan WM.
Lung cysts, spontaneous pneumothorax, and genetic associations in 89 families with Birt-Hogg-Dubé syndrome.
Am. J. Respir. Crit. Care Med. 175: 1044-53, 2007. [Journal]

29) Lattouf JB, Grubb RL, Lee SJ, Bjurlin MA, Albert P, Singh AK, Ocak I, Choyke P, Coleman JA.
Magnetic resonance imaging-directed transrectal ultrasonography-guided biopsies in patients at risk of prostate cancer.
BJU Int. 99: 1041-6, 2007. [Journal]

30) Hama Y, Bernardo M, Regino CA, Koyama Y, Brechbiel MW, Krishna MC, Choyke PL, Kobayashi H.
MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 57: 431-6, 2007. [Journal]

31) Barrett T, Brechbiel M, Bernardo M, Choyke PL.
MRI of tumor angiogenesis.
Journal of magnetic resonance imaging : JMRI. 26: 235-49, 2007. [Journal]

32) Xu H, Regino CA, Koyama Y, Hama Y, Gunn AJ, Bernardo M, Kobayashi H, Choyke PL, Brechbiel MW.
Preparation and Preliminary Evaluation of a Biotin-Targeted, Lectin-Targeted Dendrimer-Based Probe for Dual-Modality Magnetic Resonance and Fluorescence Imaging.
Bioconjug Chem. 2007. [Journal]

33) Singh AK, Guion P, Sears-Crouse N, Ullman K, Smith S, Albert PS, Fichtinger G, Choyke PL, Xu S, Kruecker J, Wood BJ, Krieger A, Ning H.
Simultaneous integrated boost of biopsy proven, MRI defined dominant intra-prostatic lesions to 95 Gray with IMRT: early results of a phase I NCI study.
Radiation oncology (London, England). 2: 36, 2007. [Journal]

34) Kobayashi H, Hama Y, Koyama Y, Barrett T, Regino CA, Urano Y, Choyke PL.
Simultaneous multicolor imaging of five different lymphatic basins using quantum dots.
Nano Lett. 7: 1711-6, 2007. [Journal]

35) Koyama Y, Hama Y, Urano Y, Nguyen DM, Choyke PL, Kobayashi H.
Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu.
Clin. Cancer Res. 13: 2936-45, 2007. [Journal]

36) Hama Y, Koyama Y, Bernardo M, Choyke PL, Kobayashi H.
Spectral near-infrared fluorescence imaging of curved surfaces using projection reconstruction algorithms.
Contrast media & molecular imaging. 2: 82-7, 2007. [Journal]

37) Gunn AJ, Hama Y, Koyama Y, Kohn EC, Choyke PL, Kobayashi H.
Targeted optical fluorescence imaging of human ovarian adenocarcinoma using a galactosyl serum albumin-conjugated fluorophore.
Cancer Sci. 98: 1727-33, 2007. [Journal]

38) Ocak I, Baluk P, Barrett T, McDonald DM, Choyke P.
The biologic basis of in vivo angiogenesis imaging.
Front. Biosci. 12: 3601-16, 2007. [Journal]

39) Gunn AJ, Brechbiel MW, Choyke PL.
The emerging role of molecular imaging and targeted therapeutics in peritoneal carcinomatosis.
Expert opinion on drug delivery. 4: 389-402, 2007. [Journal]

40) Xu H, Regino CA, Bernardo M, Koyama Y, Kobayashi H, Choyke PL, Brechbiel MW.
Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.
J. Med. Chem. 50: 3185-93, 2007. [Journal]

41) Gunn AJ, Kobayashi H, Choyke PL.
Tumor-targeted optical imaging in the management of peritoneal carcinomatosis.
South Dakota medicine : the journal of the South Dakota State Medical Association. 60: 353-7, 2007. [Journal]

42) Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H.
Two-Color Lymphatic Mapping Using Ig-Conjugated Near Infrared Optical Probes.
J Invest Dermatol. 2007. [Journal]

43) Ferrier MC, Sarin H, Fung SH, Schatlo B, Pluta RM, Gupta SN, Choyke PL, Oldfield EH, Thomasson D, Butman JA.
Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model.
Neoplasia. 9: 546-55, 2007. [Journal]

44) Choyke PL.
ACR Appropriateness Criteria(R) on Incidentally Discovered Adrenal Mass.
Journal of the American College of Radiology : JACR. 3: 498-504, 2006. [Journal]

45) Barrett T, Choyke PL, Kobayashi H.
Imaging of the lymphatic system: new horizons.
Contrast media & molecular imaging. 1: 230-45, 2006. [Journal]

46) Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H.
Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity.
Breast Cancer Res Treat. 2006. [Journal]

47) Hama Y, Urano Y, Koyama Y, Bernardo M, Choyke PL, Kobayashi H.
A comparison of the emission efficiency of four common green fluorescence dyes after internalization into cancer cells.
Bioconjug. Chem. 17: 1426-31, , ,. [Journal]

48) Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
D-galactose receptor-targeted in vivo spectral fluorescence imaging of peritoneal metastasis using galactosamin-conjugated serum albumin-rhodamine green.
Journal of biomedical optics. 12: 051501, , ,. [Journal]

49) Boswell CA, Eck PK, Regino CA, Bernardo M, Wong KJ, Milenic DE, Choyke PL, Brechbiel MW.
Synthesis, characterization, and biological evaluation of integrin alphavbeta3-targeted PAMAM dendrimers.
Mol. Pharm. 5: 527-39, , ,. [Journal]

50) Hama Y, Koyama Y, Choyke PL, Kobayashi H.
Two-color in vivo dynamic contrast-enhanced pharmacokinetic imaging.
Journal of biomedical optics. 12: 034016, , ,. [Journal]

51) Hama Y, Koyama Y, Urano Y, Choyke P, Kobayashi H.
A comparison of 4 green fluorophores in vivo.
Bioconjugate Chemistry. in press, 2006. [Journal]

52) Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin.
Biochem. Biophys. Res. Commun. 348: 807-13, 2006. [Journal]

53) Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Krishna MC, Choyke PL, Kobayashi H.
In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent.
Neoplasia. 8: 607-12, 2006. [Journal]

54) Barrett T, Kobayashi H, Brechbiel M, Choyke PL.
Macromolecular MRI contrast agents for imaging tumor angiogenesis.
Eur J Radiol. 2006. [Journal]

55) Tang JS, Choy G, Bernardo M, Thomasson D, Libutti SK, Choyke PL.
Dynamic contrast-enhanced magnetic resonance imaging in the assessment of early response to tumor necrosis factor alpha in a colon carcinoma model.
Investigative radiology. 41: 691-6, 2006. [Journal]

56) Wedam SB, Low JA, Yang SX, Chow CK, Choyke P, Danforth D, Hewitt SM, Berman A, Steinberg SM, Liewehr DJ, Plehn J, Doshi A, Thomasson D, McCarthy N, Koeppen H, Sherman M, Zujewski J, Camphausen K, Chen H, Swain SM.
Antiangiogenic and antitumor effects of bevacizuman in inflammatory and locally advanced breast cancer patients.
J Clin Oncol. Jan 3, 2006. [Journal]

57) Choyke PL.
Contrast agents for imaging tumor angiogenesis: is bigger better?.
Radiology. 235: 1-2, 2005. [Journal]

58) Talanov VS, Regino CA, Kobayashi H, Bernardo M, Choyke PL, Brechbiel MW.
Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
Nano Lett. 6: 1459-63, 2006. [Journal]

59) Kobayashi H, Kawamoto S, Brechbiel MW, Bernardo M, Sato N, Waldmann TA, Tagaya Y, Choyke PL.
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.
Neoplasia. 7: 984-91, 2005. [Journal]

60) Choyke PL, Kobayashi H.
Functional magnetic resonance imaging of the kidney using macromolecular contrast agents.
Abdominal imaging. 31: 224-31, , ,. [Journal]

61) Kobayashi H, Kawamoto S, Brechbiel MW, Bernardo M, Sato N, Waldmann TA, Tagaya Y, Choyke PL.
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.
Neoplasia. Nov;7(11): 984-91, 2005. [Journal]

62) Kobayashi H, Kawamoto S, Bernardo M, Brechbiel MW, Knopp MV, Choyke PL.
Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: Comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging.
J Control Release. 2006. [Journal]

63) Choyke PL, Kobayashi H.
Functional magnetic resonance imaging of the kidney using macromolecular contrast agents.
Abdominal Imaging. Nov 10, 2005. [Journal]

64) Zhang Y, Choyke PL, Lu H, Takahashi H, Mannon RB, Zhang X, Marcos H, Li KC, Kopp JB.
Detection and Localization of Proteinuria by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using MS325.
J Am Soc Nephrol. 16: 1752-7, 2005. [Journal]

65) Susil RC, Ménard C, Krieger A, Coleman JA, Camphausen K, Choyke P, Fichtinger G, Whitcomb LL, Coleman CN, Atalar E.
Transrectal prostate biopsy and fiducial marker placement in a standard 1.5T magnetic resonance imaging scanner.
J Urol. 175: 113-20, 2006. [Journal]

66) Matsumoto K, Bernardo M, Subramanian S, Choyke P, Mitchell JB, Krishna MC, Lizak MJ.
MR assessment of changes of tumor in response to hyperbaric oxygen treatment.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 56: 240-6, 2006. [Journal]

67) Ménard C, Susil RC, Choyke P, Coleman J, Grubb R, Gharib A, Krieger A, Guion P, Thomasson D, Ullman K, Gupta S, Espina V, Liotta L, Petricoin E, Fitchtinger G, Whitcomb LL, Atalar E, Coleman CN, Camphausen K.
An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement.
Molecular Imaging. 4(1): 63-6, 2005. [Journal]

68) Gunay-Aygun M, Avner ED, Bacallao RL, Choyke PL, Flynn JT, Germino GG, Guay-Woodford L, Harris P, Heller T, Ingelfinger J, Kaskel F, Kleta R, LaRusso NF, Mohan P, Pazour GJ, Shneider BL, Torres VE, Wilson P, Zak C, Zhou J, Gahl WA.
Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference.
J. Pediatr. 149: 159-64, 2006. [Journal]

69) Garcia-Eulate R, Hussain N, Heller T, Kleiner D, Malech H, Holland S, Choyke PL.
CT and MRI of hepatic abscess in patients with chronic granulomatous disease.
AJR. American journal of roentgenology. 187: 482-90, 2006. [Journal]

70) Schmidt LS, Nickerson ML, Warren MB, Glenn GM, Toro JR, Merino MJ, Turner ML, Choyke PL, Sharma N, Peterson J, Morrison P, Maher ER, Walther MM, Zbar B, Linehan WM.
Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dube syndrome.
Am J Hum Genet. 76: 1023-33, 2005. [Journal]

71) Pavlovich CP, Grubb RL, Hurley K, Glenn GM, Toro J, Schmidt LS, Torres-Cabala C, Merino MJ, Zbar B, Choyke P, Walther MM, Linehan WM.
Evaluation and management of renal tumors in the Birt-Hogg-Dube syndrome.
J Urol. 173: 1482-6, 2005. [Journal]

72) Wei MH, Toure O, Glenn GM, Pithukpakorn M, Neckers L, Stolle C, Choyke P, Grubb R, Middelton L, Turner ML, Walther MM, Merino MJ, Zbar B, Linehan WM, Toro JR.
Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer.
J Med Genet. 2005. [Journal]

73) Grubb RL, Choyke PL, Pinto PA, Linehan WM, Walther MM.
Management of von Hippel-Lindau-associated kidney cancer.
Nat Clin Pract Urol. 2: 248-55, 2005. [Journal]

This page was last updated on 11/20/2008.