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Study 16 of 648 for search of: | Open Studies | "Exercise" |
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Brief Title † | Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes | ||||
Official Title † | Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes | ||||
Brief Summary | Older persons with diabetes have a harder time maintaining blood pressure when standing up. When blood pressure drops when standing up, fainting may occur. This study will see how regular exercise can improve the ability of the body to keep blood pressure up when standing. We want to see how this improvement varies with different types of exercise. The types of exercise that we will be studying are aerobic (running or cycling on a stationary bike) and strength training (weight lifting). |
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Detailed Description |
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Study Phase | |||||
Study Type † | Interventional | ||||
Study Design † | Other, Randomized, Open Label, Placebo Control, Parallel Assignment, Safety/Efficacy Study | ||||
Primary Outcome Measure † | Pulse wave velocity (central and peripheral) [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Drop in middle cerebral artery velocity with upright tilting [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Drop in blood pressure with upright tilt [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Arterial baroreflex sensitivity [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Time and frequency domain measures of heart rate variability [ Time Frame: Unspecified ] [ Designated as safety issue: No ] |
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Secondary Outcome Measure † | Fasting blood glucose, HgbA1C [ Time Frame: Unspecified ] [ Designated as safety issue: No ] VO2max [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Dynamometry measures of muscle strength [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Resting and maximal heart rate [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Waist to hip ratio, BMI [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Lean body mass/% fat [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Catecholamines [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Increase in Gosling's pulsatility index [ Time Frame: Unspecified ] [ Designated as safety issue: No ] Linear transfer-function analysis of cerebral autoregulation during upright tilt [ Time Frame: Unspecified ] [ Designated as safety issue: No ] |
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Condition † | Cardiovascular Diabetic |
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Intervention † | Behavioral: Aerobic Exercise and Strength Exercise Behavioral: Strength training |
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MEDLINE PMIDs | |||||
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Recruitment Information Fields | |||||
Recruitment Status † | Recruiting | ||||
Enrollment † | 60 | ||||
Start Date † | February 2006 | ||||
Completion Date | December 2010 | ||||
Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
Overt diabetic nephropathy excluding subjects with a urine albumin to creatinine ratio of greater than 2.0 in men or 2.8 in women Diabetic retinopathy |
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Gender | Both | ||||
Ages | 65 Years and older | ||||
Accepts Healthy Volunteers | Yes | ||||
Contacts †† |
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Location Countries † | Canada | ||||
Administrative Information Fields | |||||
NCT ID † | NCT00387452 | ||||
Organization ID | CO4-0001 | ||||
Secondary IDs †† | ORSIL# 05-0820 | ||||
Study Sponsor † | University of British Columbia | ||||
Collaborators †† | Canadian Institutes of Health Research (CIHR) | ||||
Investigators † |
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Information Provided By | University of British Columbia | ||||
Verification Date | September 2008 | ||||
First Received Date † | October 11, 2006 | ||||
Last Updated Date | September 24, 2008 |