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Table of Contents Preface to the Second Edition....................................................................................... v Some Comments about the Surveys............................................................................ ix Chapter Authors......................................................................................................... xiii 1. Origins of the IACUC ...........................................................................................1 Harry Rozmiarek 2. Circumstances Requiring an IACUC ................................................................11 Richard C. Van Sluyters and Marcy Brown 3. Creation of an IACUC ........................................................................................19 Richard C. Van Sluyters and Marcy Brown 4. Reporting Lines of the IACUC ..........................................................................31 Richard C. Van Sluyters and Marcy Brown 5. General Composition of the IACUC and Specific Roles of the IACUC Members ......................................................................................37 Christian E. Newcomer 6. Frequency and Conduct of Regular IACUC Meetings ....................................61 Sreekant Murthy 7. General Format of IACUC Protocol Forms .......................................................83 Christian E. Newcomer 8. Submission and Maintenance of IACUC Protocols.........................................93 Kathy Laber and Alison Smith 9. General Concepts of Protocol Review ............................................................ 113 Ernest D. Prentice, Gwenn S.F. Oki, and Michael D. Mann 10. Amending IACUC Protocols ............................................................................139 Diane J. Gaertner and Kathleen D. Moody 11. Continuing Review of Protocols .....................................................................149 Gwenn S.F. Oki and Ernest D. Prentice 12. Justification for the Use of Animals................................................................157 Larry Carbone 13. Justification for the Number of Animals to be Used .....................................175 Ed J. Gracely 4010_C000.fm Page xix Tuesday, June 27, 2006 3:37 PM 14. Animal Acquisition and Disposition..............................................................189 Michael J. Huerkamp and David R. Archer 15. Animal Housing and Use Sites........................................................................227 Cynthia Gillett 16. Pain and Distress ..............................................................................................241 Alicia Z. Karas and Jerald Silverman 17. Euthanasia..........................................................................................................287 Peggy J. Danneman 18. Surgery ...............................................................................................................321 Lester L. Rolf, Jr. and Kathleen L. Smiler 19. Antigens, Antibodies, and Blood Collection .................................................345 Harold F. Stills, Jr. 20. Occupational Health and Safety......................................................................359 Robin Lyn Trundy, Susan Stein Cook, Robert J. Ceru and Kristin Erickson 21. Personnel Training............................................................................................379 Howard G. Rush 22. Confidential and Proprietary Information ......................................................407 Marilyn J. Chimes, Laure Bachich Ergin, and Kathryn A. Donohue 23. General Concepts of the Facility Inspection and Program Review.........................................................................................429 Stephen K. Curtis and Karen M. Janes 24. Inspection of Animal Housing Areas ..............................................................455 Patricia A. Ward 25. Inspection of Individual Laboratories ............................................................469 Neil S. Lipman and Scott E. Perkins 26. Inspection of Surgery Areas .............................................................................479 Scott E. Perkins and Neil Lipman 27. Assessment of Veterinary Care ........................................................................493 Mark A. Suckow and Bernard J. Doerning 28. Laboratory Animal Enrichment........................................................................521 Kathryn A. L. Bayne 29. Animal Mistreatment and Protocol Noncompliance......................................543 Jerald Silverman 30. Postapproval Monitoring..................................................................................571 Ron E. Banks 4010_C000.fm Page xx Tuesday, June 27, 2006 3:37 PM Appendix A. Animal Welfare Act ............................................................................593 Appendix B. Animal Welfare Act Regulations.......................................................595 Appendix C. Health Research Extension Act of 1985 (P.L. 99-158, November 20, 1985, ¿Animals In Research¿).............................603 Appendix D. Public Health Service Policy on Humane Care and Use of Laboratory Animals .......................................................................605 Appendix E. U.S. Government Principles for the Utilization and Care of Vertebrate Animals in Testing, Research, and Training ......................................................................................................613 Appendix F. Health Research Extension Act of 1985 (P.L. 99-158, November 20, 1985, ¿Animals In Research¿).............................615 Abbreviations Used in this Book ............................................................................625 Index..........................................................................................................................
Library of Congress Subject Headings for this publication:
Animal welfare.
Laboratory animals.
National Institutes of Health (U.S.). Institutional Animal Care and Use Committee.