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Title Effects of chronic exposure to ozone on collagen in rat lung
Creator/Author Wright, E.S. ; Kehrer, J.P. ; White, D.M. ; Smiler, K.L.
Publication Date1988 Mar 15
OSTI IdentifierOSTI ID: 6936275
Other Number(s)CODEN: TXAPA
Resource TypeJournal Article
Resource RelationToxicol. Appl. Pharmacol. ; Vol/Issue: 92:3
Research OrgGeneral Motors Research Labs, Warren, MI (USA)
Subject560300 -- Chemicals Metabolism & Toxicology; COLLAGEN-- BIOSYNTHESIS;LUNGS-- FIBROSIS;OZONE-- TOXICITY; AIR POLLUTION;CARBON 14 COMPOUNDS;CHRONIC EXPOSURE;DOSE-RESPONSE RELATIONSHIPS;HYDROXYPROLINE;RATS;TRACER TECHNIQUES
Related SubjectAMINES;AMINO ACIDS;ANIMALS;AZOLES;BODY;CARBOXYLIC ACIDS;HETEROCYCLIC ACIDS;HETEROCYCLIC COMPOUNDS;HYDROXY ACIDS;ISOTOPE APPLICATIONS;LABELLED COMPOUNDS;MAMMALS;ORGANIC ACIDS;ORGANIC COMPOUNDS;ORGANIC NITROGEN COMPOUNDS;ORGANS;PATHOLOGICAL CHANGES;POLLUTION;PROTEINS;PYRROLES;PYRROLIDINES;RESPIRATORY SYSTEM;RODENTS;SCLEROPROTEINS;SYNTHESIS;VERTEBRATES
Description/Abstract Pulmonary fibrosis is a consequence of severe injury from some toxic agents including high doses of ozone.^It is not known, however, whether chronic exposure to low doses of ozone, such as those encountered in polluted ambient atmospheres, could also result in abnormal accumulations of lung collagen.^Rats were exposed to ozone for 20 hr per day, 7 days per week for 3, 6, 12, and 18 months at concentrations of 0.12, 0.25, or 0.50 ppm.^Controls were exposed under identical conditions to purified air.^Upon removal from the chambers, rats were euthanized and lung tissue slices incubated with (14C)proline.^The incorporation of 14C into hydroxyproline and the total hydroxyproline content of lung tissue were measured as estimates of lung collagen synthesis and content, respectively.^The formation of labeled hydroxyproline tended to decrease significantly with time in controls and at the three ozone doses.^There were, however, no significant dose-related changes at any of the time points tested.^Total lung hydroxyproline increased with age in all groups, but no dose-related changes were detected at any time point.^It was concluded that chronic exposure of rats to ozone at concentrations which approximate ambient urban concentrations did not affect normal age-related changes in either synthesis or accumulation of lung collagen.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 445-452
System Entry Date2001 May 13

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