FORNACE LAB RECENT PUBLICATIONS     (REVIEWS at bottom of page)

Koch-Paiz, C. A., Amundson, S. A., Bittner, M., Meltzer, P., and Fornace, A.J., Jr. Functional genomics of UV radiation responses in human cells.  Mutation Res. 549:  65-78, 2004.

Bulavin, D. V., Phillips, C., Nannenga, B., Timofeev, O., Donehower, L. A., Anderson, C. W., Appella, E., and Fornace, A. J. Jr.  Inactivation of the Wip1 Phosphatase Inhibits Mammary Tumorigenesis through p38 MAPK-mediated Activation of the Ink4a/Arf Pathway.  Nature Genetics 36:  343-350, 2004.

Hildesheim, J., Awaad, R. T.,  and Fornace, A.J. Jr. p38 MAP kinase inhibitor protects the epidermis against the acute damaging effects of UV irradiation by blocking apoptosis and inflammatory responses.  J. Invest. Derm. 122:  497-502, 2004.

Hildesheim, J., Belova, G. I., Tyner, S. D., Zhou, X., Vardanian, L., and Fornace, Jr, A. J.  Gadd45a regulates matrix metalloproteinases by suppressing DNp63alpha and ß-catenin via p38 MAP kinase and APC complex activation.  Oncogene 23:  1829-1837, 2004.

Jiang, F., P. Li, A. J. Fornace, Jr, S. V. Nicosia, and W. Bai.  G2/M Arrest by 1,25 dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer.  J Biol Chem 278:  48030-48040, 2003.

Saito, S, Yamaguchi, H., Higashimoto, Y., Chao, C, Xu, Y., Fornace, A.J. Jr., Appella, E., and Anderson, C.W.  Phosphorylation Site Interdependence of Human p53 Posttranslational Modifications in Response to Stress.  J. Biol. Chem. 278:  37536–37544, 2003.

Bishop, A. J., M. C. Hollander, B. Kosaras, R. L. Sidman, A. J. Fornace, Jr, and R. H. Schiestl.  Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development.  Cancer Res 63:  5335-5343, 2003.

Yoo, J, Ghiassi, M., Jirmanova, L., Balliet, A.G., Hoffman, B., Fornace, A. J. Jr., Liebermann, D.A., Böttinger, E.P., and Roberts, A.B. TGF-b-induced apoptosis is mediated by Smad-dependent expression of GADD45B through p38 activation. J. Biol. Chem. 278:  43001-7, 2003.

Balliet, A. G., M. C. Hollander, A. J. Fornace, Jr, B. Hoffman, and D. A. Liebermann.  Comparative Analysis of the Genetic Structure and Chromosomal Mapping of the Murine Gadd45g/CR6 Gene.  DNA Cell Biol. 22:  457-468, 2003.

Amanullah, A., Azam, N., Balliet, A., Hollander, M.C., Hoffman, B., Fornace, A.J. Jr., and Liebermann, D.  Cell signalling: Cell survival and a Gadd45-factor deficiency.  Nature 424:  741, 2003.

Goloudina, A., Yamaguchi, H., Chervyakova, D. B., Appella, E, Fornace, A. J. Jr., and Bulavin, D. V.  Regulation of human Cdc25A stability by serine 75 phosphorylation is not sufficient to activate a S-phase checkpoint.  Cell Cycle 2:  473-8, 2003.    Commentary:  Neely, K.E. and Piwnica-Worms, H.  Cdc25A regulation, To destroy or not to destroy?is that the only question?  Cell Cycle 2:  455-7, 2003.

Bulavin, D. V., Demidenko, Z. N., Moody, S. A., Appella, E., and Fornace, A. J. Jr. Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in the pre-midblastula embryos. Cell Cycle 2:  263-266, 2003.  Commentary:  Manke, I. A, & Yaffe, M. B., Chk’n Out in Mitosis. Cell Cycle 2:  236-237, 2003.

Bulavin, D. V., Higashimoto, Y., Demidenko, Z. N., Meek, S., Graves, P., Phillips, C., Zhao, H., Moody, S. A., Appella, E., and Fornace, A. J. Jr.  Dual Phosphorylation Controls Cdc25 Phosphatases and Mitotic Entry.  Nature Cell Biology 5:  545-551, 2003.

Hollander, M.C., Poola-Kella, S., and Fornace, A. J. Jr.  Gadd34 functional domains involved in growth suppression and apoptosis.  Oncogene 22:  3827-3832, 2003.

Bulavin, D. V., Kovalsky, O.,  Hollander, M. C., and Fornace, A. J. Jr. Abrogation of oncogenic H-ras-induced cell-cycle arrest and p38 MAPK activation by disruption of Gadd45a. Mol. Cell. Biol. 23: 3859-3871, 2003.

Amundson, S. A., Lee, A., Koch-Paiz, C. A., Bittner, M.L., Meltzer, P., Trent, J. M., and Fornace, A. J. Jr. Differential responses of stress genes to low dose-rate g irradiation.  Molecular Cancer Res. 1:  445-452, 2003.

Hildesheim, J., Bulavin, D., Anver, M. R., Alvord, W. G., Hollander, M. C., Vardanian, L., and Fornace, Jr, A. Gadd45a protects against UV irradiation-induced skin tumors and promotes apoptosis  and stress signaling via MAP kinases and p53. Cancer Res. 62: 7305-7315, 2002.

Fan, F., Jin, S., Amundson, S. A., Tong, T., Fan, W., Zhao, H., Zhu, X., Mazzacurati, L., Li, X., Petrik, K. L., Fornace, Jr, A. J., Rajasekaran, B., and Zhan, Q. ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene 21:  7488-7496, 2002.

Morinobu, A., Gadina, M., Strober, W., Visconti, R., Fornace, A., Montagna, C., Feldman, G. M., Nishikomori, R., and O'Shea, J. J. STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci U S A 99:  12281-12286, 2002.

Bulavin, D. V., Demidov, O. N., Saito, S., Kauraniemi, P., Phillips, C., Amundson, S. A., Ambrosino, C., Sauter, G., Nebreda, A. R., Anderson, C. W., Kallioniemi, A., Fornace, Jr, A. J., and Appella, E. Amplification of the Wip1 phosphatase gene in human tumors abrogates p53 tumor-suppressor activity. Nat Genet  31:  210-215,  2002.

Salvador, J.M., Hollander, M.C., Nguyen, A.T., Kopp, J.B., Barisoni, L., Moore, J.K., Ashwell, J.D., and Fornace, A.J., Jr.  Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.  Immunity 16:  499-508, 2002.

Amundson,, S.A., Patterson, A., Do, K.T., and Fornace, A.J., Jr.  A nucleotide excision repair master-switch:  p53 regulated coordinate induction of global genomic repair genes. Cancer Biology and Therapy 1:  145-149, 2002.

Tran, H., Brunet, A., Grenier, J. M., Datta, S. R., Fornace, A. J., Jr,  DiStefano, P. S., Chiang, L. W., and Greenberg, M. E.  DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296:  530-534, 2002.

Dmitrieva, N.I., Bulavin, D.V., Fornace, A.J., Jr., and Burg, M.B.  Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase. Proc. Natl. Acad. Sci. USA 99:  184, 189, 2002.

Kovalsky, O., F. D. Lung, P. P. Roller, and A. J. Fornace, Jr.  Oligomerization of human Gadd45a protein. J. Biol. Chem. 276:  39330-39339, 2001.

Bulavin, D. V., Y. Higashimoto, I. J. Popoff, W. A. Gaarde, V. Basrur, O. Potapova, E. Appella, and A. J. Fornace, Jr.  Initiation of a G2/M checkpoint after UV radiation requires p38 kinase. Nature 411:  102-107, 2001.

Kovalsky, O., F. D. Lung, P. P. Roller, and A. J. Fornace, Jr.  Oligomerization of human Gadd45a protein. J. Biol. Chem. 276:  39330-39339, 2001.

Bulavin, D. V., Y. Higashimoto, I. J. Popoff, W. A. Gaarde, V. Basrur, O. Potapova, E. Appella, and A. J. Fornace, Jr.  Initiation of a G2/M checkpoint after UV radiation requires p38 kinase. Nature 411:  102-107, 2001.

Hollander, M. C., O. Kovalsky, J. M. Salvador, K. E. Kim, A. D. Patterson, D. C. Hairnes, and A. J. Fornace, Jr.  DMBA carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency. Cancer Res. 61:  2487-2491, 2001.

Hollander, M. C., Sheikh, M. S., Yu, K., Zhan, Q., Iglesias, M., Woodworth, C., and Fornace, A.J., Jr.  Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. Int. J. Oncology: Radiation Oncology Investigations:  Basic & Clinical Res., 96:  22-31, 2001.

Amundson, S.A., Myers, T.G., Scudiero, D., Kitada, S., Reed, J.C., and Fornace, A.J., Jr.  An informatics approach identifying markers of chemosensitivity in human cancer cell lines.  Cancer Res. 60:  6101-6110, 2000.

Jin, S., H. Zhao, F. Fan, P. Blanck, W. Fan, A. B. Colchagie, A. J. Fornace, Jr, and Q. Zhan.  BRCA1 activation of the GADD45 promoter. Oncogene 19:  4050-4057, 2000.

Koch-Paiz, C.A., Momenan, R., Amundson, S.A., Lamoreaux, E., and Fornace, A.J., Jr.  Estimation of relative mRNA content by filter hybridization to a polyuridylic probe.  Biotechniques 29:  706-714, 2000.

Amundson, S.A., K.T. Do, S. Shahab Bittner, M., Meltzer, P., Trent, J., and Fornace, A.J., Jr. Identification of potential mRNA markers in peripheral blood lymphocytes for human exposure to ionizing radiation.  Radiation Res. 154:  342, 2000.

Zhao, H., Jin, S., Antinore, M.J., Lung, F.D.L., Fan, F., Blanck, P., Roller, P., Fornace, A.J., Jr., and Zhan, Q.  The central region of Gadd45 is required for its interaction with p21/Waf1.  Experimental Cell Res. 258:  92-100, 2000.

Jin, S., Antinore, M.J., Lung, F.D.T., Dong, X., Chao, H., Fan, F., Colchagie, A.B., Blanck, P., Roller, P.R., Fornace, A.J., Jr., and Zhan, Q.  The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression.  J. Biol. Chem. 275:  16602-8, 2000.

Smith, M. L., Ford, J. M., Hollander, M. C., Bortnick, R. A., Amundson, S. A., Seo, Y. R., Deng, C. X., Hanawalt, P. C., and Fornace, Jr, A. J.  p53-mediated DNA responses to UV radiation:  studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol. Cell. Biol. 20:  3705-3714, 2000.

Elizondo, G., Fernandez-Salguero, P., Sheikh, M. S., Kim, G. Y., Fornace, A. J., Lee, K. S., and Gonzalez, F. J.  Altered Cell Cycle Control at the G(2)/M Phases in Aryl Hydrocarbon Receptor-Null Embryo Fibroblast. Mol Pharmacol 57:  1056-1063, 2000.

Meng, R.D., McDonald, E.R., Sheikh, M.S., Fornace, A.J., Jr., El-Deiry, W.S.  The TRAIL Decoy receptor TRUNDD (DcR2, TRAIL-R4I) is induced by Adenovirus-p53 overexpression and can delay TRAIL-, p53-, and Killer/DR5-dependent colon cancer apoptosis.  Mol. Therapy 1:  130-144, 2000.

Bulavin, D., Saito, S. I., Hollander, M. C., Sakaguchi, K., Anderson, C. W., Appella, E., and Fornace, Jr, A. J.  Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation which mediates activation of transcription and apoptosis in response to UV radiaton. EMBO J. 18:  6845-6854, 1999.

Graunke D.M., Fornace A.J., Jr., Pieper R.O.  Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation.  Nucleic Acids Res. 27:  3881-3890, 1999.

Hollander, M. C., Sheikh, M. S., Bulavin, D., Lundren, K., Augeri-Henmueller, L., Shehee, R., Molinaro, T., Kim, K., Tolosa, E., Ashwell, J. D., Rosenberg, M. D., Zhan, Q., Fernández-Salguero, P. M., Morgan, W. F., Deng, C. X., and Fornace, A.J., Jr.  Genomic instability in Gadd45a-deficient mice.  Nature Genetics 23:  176-184, 1999.

Adler, H. T., Chinery, R., Wu, D. Y., Kussick, S. J., Payne, J. M., Fornace, Jr, A. J., and Tkachuk, D. C.  Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins. Mol. Cell. Biol. 19:  7050-7060, 1999.

Goldwasser, F., Bae, I., Pommier, Y., and Fornace, Jr, A. J.  Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation. Anticancer Res. 19:  3167-3171, 1999.

Amundson, S. A., Do, K. T., and Fornace, A.J., Jr.  Induction of Stress Genes by Low Doses of Gamma Rays.  Radiat Res 152:  225-231, 1999.

Rishi, A. K., Sun, R. J., Gao, Y., Hsu, C. K., Gerald, T. M., Sheikh, M. S., Dawson, M. I., Reichert, U., Shroot, B., Fornace, Jr, A. J., Brewer, G., and Fontana, J. A.  Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437. Nucleic Acids Res 27:  3111-3119, 1999.

Sheikh, M.S., Huang, Y., Fernandez-Salas, E.A., El-Deiry, W.S., Friess, H., Amundson, S., Yin, J., Meltzer, S.J., Holbrook, N.J., and Fornace, A.J., Jr.  The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract.  Oncogene 18:  4153-4159, 1999.

Amundson, S.A., Bittner, M., Yidong, C., Trent, J., Meltzer, P., and Fornace, A.J., Jr.  Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses.  Oncogene 18:  3666-3672, 1999.

Rishi, A. K., R. J. Sun, Y. Gao, C. K. Hsu, T. M. Gerald, M. S. Sheikh, M. I. Dawson, U. Reichert, B. Shroot, A. J. Fornace, Jr, G. Brewer, and J. A. Fontana.  Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437. Nucleic Acids Res 27:  3111-3119, 1999.

Huang, Y., Sheikh, M.S., Fornace, A.J., Jr., and Holbrook, N.J.  Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells.  Oncogene 18:  3431-3439, 1999.

Sheikh, M. S., E. Fernandez-Salas, M. Yu, A. Husssain, J. D. Dinman, S. W. Peltz, Y. Huang, and A. J. Fornace, Jr.  Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1A121/SUI1). J. Biol. Chem. 274:  16487-16493, 1999.

Zhan, Q., Antinore, M., Wang, X.W., Carrier, F., Smith, M.L., Harris, C.C., and Fornace, A.J., Jr.  Association with Cdc2  and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45.  Oncogene 18:  2892-2900, 1999.

Wang, X. W., Q. Zhan, J. D. Coursen, M. Khan, H. U. Kontny, L. Liu, M. C. Hollander, P. M. O'Connor, A. J. Fornace, Jr, and C. C. Harris.  Gadd45 induction of a G2-M cell cycle checkpoint. Proc. Natl. Acad. Sci. USA 96:  3706-3711, 1999.

Carrier, F., Georgel, P.T., Pourquier, P., Blake, M., Kontny, H.U., Antinore, M.J., Gariboldi, M., Myers, T. G, Weinstein, J.N., Pommier, Y., and Fornace, A.J., Jr.  Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.  Molec. Cell. Biol. 19:  1673-1685, 1999.

Zhan, Q., Kontny, U., Iglesias, M., Alamo, I., Jr., Yu, K., Hollander, M.C., Woodworth, C.D., and Fornace, A.J., Jr.  Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stress. Oncogene 18:  297-304, 1999.

Sheikh, M.S., Antinore, M.J., Huang, Y, and Fornace, A.J., Jr.  Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1.  Oncogene 17:  2555-2564, 1998.

Amundson, S.A., Zhan, Q., Penn, L.Z. and Fornace, A.J., Jr.  Myc suppresses induction of the growth arrest genes gadd34, gadd45 and gadd153 by DNA-damaging agents.  Oncogene  17:  2149-2154, 1998.

Zaher, H., P. M. Fernandez-Salguero, J. Letterio, M. S. Sheikh, A. J. Fornace, Jr., A. B. Roberts, and F. J. Gonzalez.  The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. Mol. Pharmacol. 54:  313-321, 1998.

Smith, M.L., Bortnick, R.A., Sheikh, M.S., and Fornace, Jr., A.J. Chromatin relaxation by overexpression of mutant p53, HPV16-E6, or cyclin G transgenes. Exp Cell Res 242:235-243, 1998.

Carrier, F., Zhan, Q., Alamo, Jr, I., Hanaoka, F., and Fornace, Jr, A.J.  Evidence for distinct kinase-mediated pathways in gadd gene responses. Biochemical Pharmacology 55:  853-861 1998.

Zhan, Q., Chen, I.T., and Fornace, Jr, A.J. Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding. Molec. Cell. Biol. 18:  2768-2778, 1998.

Sheikh, M.S., Burns, T.F., Huang, Y., Wu, G.S., Amundson, S., Brooks, K.S., Fornace, A.J., Jr. and El-Deiry, W.S.  p53-dependent and independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and TNFa.  Cancer Res. 58:  1593-1598, 1998.

Zhang, L., Q. Zhan, S. Zhan, F. Kashanchi, A. J. J. Fornace, P. Seth, and L. J. Helman.  p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells. DNA Cell Biol. 17:  125-131, 1998.

Sheikh, M.S., Carrier, F., Papathanasiou, M.A., Hollander, M.C., Zhan, Q., Yu, K. and Fornace Jr., A.J.  Identification of several human homologs of hamster DNA damage inducible transcripts: cloning and characterization of novel UV inducible cDNA which codes for a putative RNA binding protein. J. Biological Chemistry 272:  26720-26726, 1997.

O’Connor, P.M., Jackman, J., Bae, I., Myers, T.G., Fan, S., Mutoh, M., Scudiero, D.A., Monks, A., Paull, K., Sausville, E.A., Weinstein, J.N., Friend, S., Fornace, Jr, A.J., and Kohn, K.W.  Characterization of the p53 tumor suppressor pathway in cell lines of the NCI anticancer drug screen and correlations with the growth inhibitory potency of 123 anticancer agents.  Cancer Res. 57:  4285-4300, 1997.

Sheikh, M.S., Carrier, F., Johnson, A.C., Ogdon, S.E. and  Fornace Jr., A.J.    Identification of an additional p53 regulatory site in the human epidermal growth factor receptor gene promoter.  Oncogene 15:  1095-1101, 1997.

Marhin, W.W., Chen, S., Facchini, L.M., Fornace, Jr., A.J., and Penn, L.Z.  Myc represses the growth arrest gene gadd45.  Oncogene 14:  2825-2834, 1997.

Fan, S., Chang, J.K., Smith, M.L., Duba, D., Fornace, Jr, A.J., and O'Connor, P.M. Cells lacking CIP1/WAF1 genes exhibit enhanced sensitivity to cisplatin and nitrogen mustard, Oncogene 14:  2127-2136, 1997.

Hollander, M.C., Zhan, Q., Bae, I., Iglesias, M., Woodworth, C., and Fornace, Jr, A.J. Mammalian GADD34, a DNA damage-inducible gene associated with apoptosis. J. Biological Chemistry 272:  13731-13737, 1997.

Sheikh, M.S.,  Chen, Y.Q., Smith, M.L., and  Fornace Jr., A.J.  Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 14:  1875-1882, 1997.

Smith, M. L., H. U. Kontny, R. Bortnick, and A. J. Fornace, Jr.  The p53-regulated cyclin G gene promotes cell growth:  p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. Exp. Cell Res. 230:  61-8, 1997.

Zhan, Q., Bae, I., Fornace, Jr, A.J., and Craig, R.W. Induction of Bcl-2 Family Member Mcl-1 as an Early Response to DNA Damage. Oncogene 14:  1031-9, 1997.

Weinstein, J.N., Myers, T.G., O’Connor, P.M., Friend, S.H., Fornace, A.J., Jr., Kohn, K.W., Fojo, T., Bates, S.E., Rubinstein, L.V., Anderson, N.L., Buolamwini, J.K., van Osdol, W.W., Monks, A.P., Scudiero, D.A., Sausville, E.A., Zaharevitz, D.W., Bunow, B., Viswanadhan, V.N., Johnson, G.S., Wittes, R.E., and Paull, K.D.  An information-intensive approach to the molecular pharmacology of cancer.  Science 275:  343-349, 1997.

Goldwasser, F., Bae, I., Fornace, Jr, A.J., and Pommier, Y. Differential GADD45, p21CIP1/WAF1, MCL1, and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. Oncol. Res. 8:  317-323, 1996.

Chen, M.S., Fornace, A., Jr., and Laszlo, A.  Characterization of an hsp70 related clone encoding a 33 kDa protein with homology to a protein which associates with polysomes.  Biochim Biophys Acta 1297:  124-6, 1996.

Sheikh, M. S., M. Garcia, Q. Zhan, Y. Liu, and A. J. Fornace, Jr.  Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells. Cell Growth Diff. 7:  1599-1607, 1996.

Zhan, Q., Alamo, Jr, I., Yu, K., Boise, L.H., O'Connor, P.M., and Fornace, Jr, A.J. The apoptosis-associated g-ray response of BCL-XL depends on normal p53 function. Oncogene 13:  2287-2293, 1996.

Smith, M.L., Kontny, H.U., Zhan, Q., Sreenath, A., O'Connor, P.M., and Fornace, A.J., Jr.  Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to UV-irradiation or cisplatin.  Oncogene 13:  2255-2263, 1996.

Zhan, Q.,  Fan, S., Smith, M.L., Bae, I., Yu, K., Alamo, I., Jr., O’Connor, P.M. and Fornace, A.J., Jr.  Abrogation of p53 function affects gadd gene responses to DNA-base damaging agents and starvation.  DNA and Cell Biology 15:  805-815, 1996.

Vairapandi, M., Balliet, A.G., Fornace, A.J., Jr., Hoffman, B., and Liebermann, D.A.  The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.  Oncogene 12:  2579-2594, 1996.

Carrier, F., Bae, I., Smith, M.L., Ayers, D.M., and Fornace, A.J., Jr.  Characterization of the GADD45 response to ionizing radiation in WI-L2-NS cells, a line containing a p53 mutation. Mutation Res. 352:  79-86, 1996.

Hollander, M.C., Alamo, I., and Fornace, A.J., Jr.  A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product.  Nucleic Acids Res. 24:  1589-1593, 1996.

Zhang, L., Kashanchi, F. Zhan, Q., Brady, J.N., Fornace, A.J., Seth, P., and Helman, L.J.  Regulation of insulin-like growth factor II P3 promoter by p53:  a potential mechanism for tumorigenesis.  Cancer Res. 56:  1367-1373, 1996.

Bae, I., Smith, M.L., Zhan, Q., Friend, S.H., O’Connor, P.M., and Fornace, A.J., Jr.  An abnormality in the p53 pathway following g-irradiation in many wild-type p53 human melanoma lines.  Cancer Res. 56:  840-847, 1996.

Chen, I.T., Akamatsu, M., Smith, M.L., Roller, P.P., Fornace, A.J., Jr., and O’Connor, P.M.  Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.  Oncogene 12::  595-607, 1996.

Kilpatrick, K. E., F. Carrier, M. L. Smith, C. Y. Chen, A. J. Lee, D. W. Rusnak, M. B. Kastan, A. J. J. Fornace, B. R. Champion, T. M. Gilmer, and et al.  The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. Hybridoma 14:  355-359, 1995.

Gu, J., Dubner, R., Fornace, A.J., Jr., and Iadarola, M.J.  UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation.  Oncogene 11:  2175-2178, 1995.

Chen, I.T., Smith, M.L., O’Connor, P.M., and Fornace, A.J. Jr.  Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA.  Oncogene 11:  1931-1937, 1995.

Bae, I., Fan, S., Bhatia, K., Kohn, K.W., Fornace, A.J. Jr., and O’Connor, P.M.  Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following g-irradiation of human lymphoma cells. Cancer Res. 55:  2387-2393, 1995.

Kashima, N., Ueohzono, T., Fornace, A.J., Jr., and Ide, T.  Induction of gadd153 in G0-specific ts mutant cells at nonpermissive temperature.  Experimental Cell Res. 217:  324-328, 1995.

Zhan, Q., El-Deiry, W.,  Bae, I., Alamo, I. Jr., Kastan, M.B., Vogelstein, B., and Fornace, A.J., Jr.  Similarity of the DNA-damage responsiveness and growth-suppressive properties of WAF1/CIP1 and GADD45.  Int. J. Oncology 6:  937-946, 1995.

Bae, I., Smith, M.L., and Fornace, A.J., Jr.  Induction of p53-, MDM2- and p21WAF1/CIP1-like molecules in insect cells by DNA-damaging agents.  Experimental Cell Res. 217:  541-545, 1995.

Fan, S., Smith, M.L., Rivet, D.J., II, Duba, D., Zhan, Q., Kohn, K.W., Fornace, A.J., Jr., and O'Connor, P.M.  Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplain and pentoxifylline.  Cancer Res. 8:  1649-1654, 1995.

Smith, M.L., Chen., I.T., Zhan, Q., O’Connor, P.M.,  and  Fornace, A.J. Jr.  Involvement of the p53 tumor suppressor in repair of UV-type DNA damage.  Oncogene 10:  1053-1059, 1995.

Hollander, M.C., Tan, K.B.,and Fornace, A.J., Jr.:  Overexpression of the radiation inducible gene, GADD153, in drug-resistant Burkitt lymphoma cells.  Radiation Oncology Investigations:  Basic and Clinical Res. 2:  157-163, 1994.

Carrier, F., Smith, M.L., Bae, I., Kilpatrick, K.E., Chen, C.-Y., Engelstein, M., Friend, S.H., Johnson, K.J., Henner, W.D., Gilmer, T.M., Kastan, M.B., and Fornace, A.J. Jr.  Characterization of human Gadd45, a p53-regulated protein.  J. Biol. Chem. 269:  32672-32677, 1994.

Zhang, H., Cooney, D.A., Sreenath, A., Zhan, Q., Agbaria, R., Stowe, E.E., Fornace, A.J., Jr., and Johns, D.G.:  Quantitation of mitochondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method:  application to the study of inhibitors of mitochondrial DNA content.  Molecular Pharmacology 46:  1063-1069, 1994.

Smith, M.L., Zhan, Q., Bae, I., and Fornace, A.J., Jr.:  Role of retinoblastoma gene product in p53-mediated DNA damage response.  Experimental Cell Res. 215:  386-389, 1994.

Zhan, Q., Fan, S., Bae, I., Guillouf, C., Liebermann, D.A., O'Connor, P.M., Fornace, A. J., Jr.:   Induction of BAX by genotoxic stress in human cells correlates with normal p53 status and apoptosis.  Oncogene 9:  3743-3751, 1994.

Fan, S., El-Deiry, W.S., Bae, I., Freeman, J., Jondle, D., Bhatia, K., Fornace, A.J., Jr., Magrath, I., Kohn, K.W., and O’Connor, P.M.:  p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.  Cancer Res. 54:  5824-5830, 1994.

Smith, M.L., Chen., I.T., Zhan, Q., Bae, I., Chen, C.Y., Gilmer, T.M.,  Kastan, M.B., O’Connor, P.M., and Fornace, A. J., Jr.:  Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen.  Science 266:  1376-1380, 1994.  See also "Research News" New link found between p53 and DNA repair, Science 266:  1321-1322.

Jackman, J., Alamo, I., and Fornace, A.J., Jr.:  Genotoxic stress confers preferential and coordinate mRNA stability on the five gadd genes. Cancer Res. 54:  5656-5662, 1994.

Canman, C.E., Wolff, A.C., Chen, C.Y., Fornace, A.J., Jr., and Kastan, M.B.:  The p53-dependent G1 cell cycle checkpoint pathway and ataxia telangiectasia.  Cancer Res. 54:  5054-5058, 1994.

Graeber, T.G., Peterson, J.F., Tsai, M., Monica, K., Fornace, A.J., Jr., and Giaccia, A.J.:  Hypoxia induces the accumulation of p53 protein, but the activation of a G1-phase checkpoint by low oxygen conditions is independent of p53 status.  Molec. Cell. Biol. 14:  6264-6277, 1994.

Carrier, F., McCary, J.M., Bae, I., Yarosh, D.B., and Fornace, A.J., Jr.:  Activation of HIV Type 1 Long Terminal Repeat by Ultraviolet light is serum and strain specific.  AIDS Res. and Human Retroviruses, 10   767-773, 1994.

Zhan, Q., Bae, I., Kastan, M.B., and Fornace, A.J. Jr.:  The p53-dependent g-ray response of GADD45.  Cancer Res. 54:  2755-2760, 1994.

Chen, C.Y., Oliner, J.D., Zhan, Q., Fornace, A.J. Jr., Vogelstein, B., and Kastan, M.B.:  Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.  Proc. Natl. Acad. Sci. USA, 91:  2684-2688, 1994.

Zhan, Q., Lord, K.A., Alamo, I, Hollander, M.C., Carrier, F., Ron, D., Kohn, K.W., Hoffman, B., Liebermann, D., and Fornace, A.J. Jr.:  The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that cooperatively suppress cell growth.  Molec. Cell. Biol. 14:  2361-2371, 1994.

Carrier, F., Gatignol, A., Hollander, M.C., Jeang, K.T., and Fornace, A.J., Jr.:  Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents.  Proc. Natl. Acad. Sci. USA:  91:  1554-1558, 1994.

Hollander, M.C.,  Alamo, I., Jackman, J, Wang, M.G., McBride, O.W.,  Fornace, A.J., Jr.:  Analysis of the mammalian gadd45 gene and its response to DNA damage.  J. Biol. Chem. 268:  24385-24393, 1993.

Zhan, Q., Carrier, F, and Fornace, A.J. Jr.:  Induction of cellular p53 activity by DNA-damaging agents and growth arrest.  Molec. Cell. Biol. 13:  4242-4250, 1993.

Yarosh, D. B., Alas, L., Kibitel, J., O'Connor, A., Carrier, F., and Fornace, Jr, A. J.:  Cyclobutane pryrimidine dimers in UV-DNA induce release of soluble mediators which activate the human immunodeficiency virus promoter.  J. Invest. Dermatol.100:  790-4, 1993.

Kastan, M.B., Zhan, Q, El-Deiry, W.S., Carrier, F, Jacks, T., Walsh, W.V., Plunkett, B.S., Vogelstein, B., and Fornace, A.J. Jr.:  A mammalian cell cycle checkpoint utilizing p53 and GADD45 is defective in ataxia telangiectasia.  Cell 71:  587-597, 1992.
 
 
 
 

REVIEWS, BOOK CHAPTERS, AND OTHER INVITED PUBLICATIONS

Bulavin, D. B. and Fornace, A. J., Jr. p38 MAP kinase's emerging role as a tumor suppressor.  Advances in Cancer Research, Elsevier Publishers, (eds. Klein and Vande Woude) Volume 92: in press, 2004.

Hildesheim, J., and A. J. Fornace, Jr.  The dark side of light: The damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis.  DNA Repair 3:  567-580, 2004.

Amundson, S. A., and A. J. J. Fornace.  Microarray approaches for analysis of cell cycle regulatory genes.  Methods Mol Biol 241:  125-141, 2004

Rockett, J. C., Burczynski, M. E., Fornace, A. J., Jr., Herrmann, P.C., Krawetz, S. A., and Dix, D. J.  Surrogate Tissue Analysis: Monitoring Toxicant Exposure And Health Status Of Inaccessible Tissues Through The Analysis Of Accessible Tissues And Cells. Toxocol. and Applied Pharmacol., 194:  189-199, 2004.

Amundson, SA and Fornace, A.J., Jr.  Complexity of stress signaling and responses, in Handbook of Cell Signaling (Karin, M, et al. ed.)  Academic Press, San Diego, CA, 3:  179-184, 2003.

Amundson, S.A. and Fornace, A.J., Jr.  Monitoring human radiation exposure by gene expression profiling:  Possibilities and Pitfalls.  Health Physics, 85: 36-42, 2003. 

Amundson, S.A., Bittner, M., and Fornace, A. J., Jr. Functional genomics as a window on radiation stress signaling.  Oncogene 22:  5828-5833, 2003.

Amundson, S. A., K. T. Do, P. Meltzer, J. Trent, M. Bittner, and A. J. Fornace, Jr.  Stress-gene induction by low-dose gamma-irradiation. Military Med. 167:  13-15,  2002.

Bulavin, D, Amundson, S.A., and Fornace, A.J., Jr. p38 and Chk1 kinases: different conductors for the G2/M checkpoint symphony.  Current Opinion in Genetics and Development, 12:  92-97, 2002.

Smith, M.L., and Fornace, A.J., Jr.  Commentary:  Chemotherapeutic Targeting of p53.  Cancer Biology & Therapy 1:  56-57, 2002.

Hildesheim, J., and Fornace, Jr, A. J. Gadd45a: An Elusive Yet Attractive Candidate Gene in Pancreatic Cancer: Commentary re: K. Yamasawa et al., Clinicopathological Significance of Abnormalities in Gadd45 Expression and Its Relationship to p53 in Human Pancreatic Cancer. Clin. Cancer Res., 8: 2563-2569, 2002. Clin Cancer Res 8:  2475-2479, 2002.

Carrier, F., and Fornace, A.J., Jr. Ataxia-Telangiectasia Syndrome.  In Encyclopedia of Cancer, J. R. Bertino (ed.), Academic Press, San Diego, CA., in press, 2002.

Amundson, SA and Fornace, A.J., Jr. (2002)  Microarray approaches for analysis of tumor suppressor gene function, in Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal
Applications (El-Deiry, WS, ed.) Humana Press, Totowa, NJ., in press, 2002.

Hollander, M. C., and Fornace, A. J. Jr. Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a. Oncogene 21:  6228-6233, 2002.

Amundson, S. A., P. Meltzer, J. Trent, M. Bittner, and A. J. Fornace, Jr.  Induction of gene expression as a monitor of radiation exposure. Radiation Res. 156:  657-61, 2001.

Amundson, S. A., P. Meltzer, J. Trent, M. Bittner, and A. J. Fornace, Jr.  Physiological function as regulation of large transcriptional programs:  The cellular response to genotoxic stress.  Comparative Biochemistry and Physiology 129:  703-710, 2001.

Amundson, S. A., P. Meltzer, J. Trent, M. Bittner, and A. J. Fornace, Jr.  Biological indicators for the identification of radiation exposure in humans. Expert Review of Molecular Diagnostics  1:
89-97, 2001.

Amundson, S.A. and Fornace, A.J., Jr.  Gene expression profiles for monitoring radiation exposure.  Radiation Protection Dosimetry, 97:  11-16, 2001.

 Amundson, S.A., Bittner, M. and Fornace, A.J., Jr.  Microarray approaches for analysis of tumor suppressor gene function, in Tumor Suppressor Genes:  Methods and Protocols (El-Deiry, W.S., ed.) Humana Press, Totowa, NJ, in press:  2001.

Fornace, A.J., Jr., Fuks, Z., Weichselbaum, R. R., and Milas, L. Radiation therapy. In The Molecular Basis of Cancer, Second Edition.  Mendelsohn, J., Howley, P. M., Israel, M. A., and Liotta, L. A. (ed.), p.423-466, W. B. Saunders Co., Philadelphia., 2001.

Sheikh, M.S., and Fornace, A.J., Jr.  Death and decoy receptors and p53-mediated apoptosis.  Leukemia 14:  1509-13, 2000.

Sheikh, M.S., Hollander, M.C. and Fornace, A.J., Jr.  Role of Gadd45 in apoptosis. Biochemical Pharmacology 59:  43-45, 2000.

Sheikh, M.S., and Fornace, A.J., Jr.  Role of p53 family members in apoptosis.  J. Cell. Physiol.  182:  171-181, 2000.

Bittner, M., Y. Chen, S. A. Amundson, J. Khan, A. J. Fornace, Jr, E. R. Dougherty, P. S. Meltzer, and J. M. Trent.  Obtaining and evaluating gene expression profiles with cDNA microarrays. Proceedings of the International Conference on Genomics and Proteomics:  Functional and Computational Aspects in press, 1999.

Sheikh, M.S., and Fornace, A.J., Jr.  Regulation of translation initiation following stress.  Oncogene 18:  6121-6128, 1999.

Fornace, A.J., Jr., Amundson, S.A., Bittner, M., Myers, T.G., Weinstein, J.N., Meltzer, P., and Trent, J.  The complexity of radiation stress responses:  analysis by informatics and functional genomics approaches.  Gene Expression, 7:  387-400, 1999.

Amundson, S. A., T. G. Myers, and A. J. Fornace, Jr.  Roles for p53 in growth arrest and apoptosis:  Putting on the brakes after genotoxic stress. Oncogene 17:  3287-3300, 1998.

Smith, M.L., and Fornace, A.J., Jr.  Correspondence re: J. S. DeFrank et al., p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine. Cancer Res., 56: 5365-5368, 1996 [letter]. Cancer Res. 57:  5434-5436, 1997.

"Albert J. Fornace, Jr.:  a member of The Editorial Academy of The International Journal of Oncology," Cover Legend.  Int. J. Oncology 12:  3-4, 1998.

Fornace, A.J., Jr.  Genotoxic stress responses associated with growth arrest and apoptosis, and the role of p53 in their regulation.  In:  Molecular Toxicology, utilitzation in accelerated drug discovery and chemical safety analysis, edited by Guttry, P., IBC Inc., Southborough, MA, p. 1-8, 1997.

Smith, M.L. and Fornace, A.J. Jr.:  p53-mediated protective responses to UV irradiation.   Proc. Natl. Acad. Sci. U S A 94:  12255-12257, 1997.

Akamatsu, M., Chen, I-T., Fornace, A.J., Jr., O’Connor, P.M., and Roller, P.P.  Conformational mapping of p21!af1/Cip1 protein, and cyclin dependent kinase-modulating effect of its peptide fragments.  In:  Peptides: Chemistry, Structure and Biology, edited by Kaumaya, P.T.P. and Hodges, R.S., Mayflower Scientific Ltd., p.370-371, 1996.

Smith, M.L. and Fornace, A.J. Jr.:  The two faces of tumor suppressor p53-EDITORIAL.  Amer. J. Pathology 148:  1019-1022, 1996.

Gorospe, M., Martindale, J.L., Sheikh, M.S., Fornace, A.J. Jr.,  and Holbrook, N.J.:  Regulation of p21CIP1/WAF1 expression by cellular stress:   p53-dependent and p53-independent mechanisms.  Molecular Cellular Differentiation 4: 47-65, 1996.

Holbrook, N.J., Liu, Y., and Fornace, A.J. Jr.:  Signaling events controlling the molecular response to genotoxic stress.  In:  Stress-inducible Cellular Responses; edited by Feige, U., Morimoto, R.I., Yahara, I., and Polla, B.S., Birkhauser Verlag, Basel, Switzerland, p. 273-288, 1996.

Smith, M.L. and Fornace, A.J. Jr.:  Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis.  Mutation Res. 340:  109-124, 1996.

Carrier, F., and A. J. Fornace, Jr.  Ataxia-Telangiectasia Syndrome. p. 100-111. In Encyclopedia of Cancer, vol. 1, J. R. Bertino (ed.), Academic Press, San Diego, CA., 1996

Hollander, M. C. and Fornace, A.J. Jr.:  Cell cycle checkpoints and growth-arrest genes activated by genotoxic stress. In: Vos, J. M. H. (eds.), DNA Repair Mechanisms: Impact on Human Diseases and Cancer, pp. 221-237, Georgetown, TX: R. G. Landes Company, 1995.

Smith, M.L. and Fornace, A.J., Jr.:  Genomic instability and the role of p53 mutations in cancer cells.  Current Opinion in Oncology 7:  69-75, 1995.

Thompson, L.H., Fornace, A.J. Jr., Caldecott, K.W., Brookman, K.W., Weber, C.A., Salazar, E.S., and Takayama, K.:  Recent developments with the human repair genes ERCC2, ERCC4, and XRCC1.  In DNA Repair Mechaniisms, Alfred Benzon Symposium 35, edited by V.A. Bohr, K. Wassermann, and K. Kraemer.  Munksgaard, Copenhagen, 42-53, 1992.

Fornace, A.J., Jr., Jackman, J., Hollander, M.C., Hoffman-Liebermann, B., and Liebermann, D.A.:  Genotoxic-stress-response genes and growth-arrest genes;  the gadd, MyD, and other genes induced by treatments eliciting growth arrest.  Annals N.Y. Acad. Sci. 663: 139-153, 1992.

Fornace, A.J., Jr.:  Mammalian genes induced by radiation;  activation of genes associated with growth control.  Annual Rev. Genetics 26:  507-526, 1992.
 
 
 
 
 

Click for MEDLINE listing of above publications