1. Journal Articles

2000

Thompson, K.L., Rosenzweig, B.A., Tsong, Y, Sistare, F.D. (in press 2000) Evaluation of in vitro reporter gene induction assays for use in a rapid prescreen for compound selection to test specificity in the Tg.AC mouse short-term carcinogenicity assay. Toxicological Sciences 57#-#.

Honchel R, Rosenzweig BA, Thompson KL, Blanchard KT, Furst SM, Stoll RE, Sistare FD: Loss of palindromic symmetry in Tg.AC mice with a nonresponder phenotype. Molecular Carcinogenesis (In Press).

Herman E.H., Zhang, J., Chadwick, D.P., Ferrans, V.J. (2000) Comparison of the protective effects of WR-2721 and dexrazoxane against the doxicity of doxirubicin in spontaneously hypertensive rats. Cancer Chemoth. and Pharmacol. 45 329-334.

Weaver J.L.(2000) Introduction to Flow Cytometry (Editorial). Methods 21 199-201.

Weaver, J.L., Torous, D. (2000) Development of a Flow Cytometry Assay for Counting Micronucleated Erythrocytes: Beyond the Basics. Methods 21 281-287.

1999

Szabo, D., Szabo, G., Ocsovski, I., Aszalos, A., Molnar, J. (1999) Anti-psychotic drugs reverse multi-drug resistance of tumor cell lines and human AML cells ex vivo. Anticancer Lett. 139 115-119

Aszalos, A., Thompson, K., Yin, J-J., and Ross, D.D. (1999) Comparison of the effects of p-glycoprotein blockers verapamil, PSC833, and cremaphor on the multidrug resistance associated protein (MRP) and on p-glycoprotein (Pgp). Anticancer Res. 19: 1053-1064.

Szabo, Diana; Szabo Jr, Gabor; Ocsovszki, Imre; Aszalos, Adorjan; Molnar, Jozsef. (1999) Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo. Cancer Letters 139 115-119.

Lester, D.S., Lyon, R.C, McGregor, G.N., Engelhardt, R.T., Schmued, L.C., Johnson, G.A. and Johannessen, J.N. (1999) 3-Dimensional Visualization of Excitotoxic Lesions in Rat Brain using Magnetic Resonance Imaging Microscopy (1999) NeuroProtocols 10:737-741.

Kidder, L.H., Colarusso, P., Stewart, S.A., Levin, I.W., Appel, N.M., Lester, D.S., Pentchev, P.G. and Lewis, E.N.. Infrared spectroscopic imaging of biochemical modifications induced in the cerebellum of the Niemann-Pick type C mouse(1999). J.Biomed.Optics 4(1):7-13.

Lester, D.S., Johannessen, J.N., McGregor, G.N., and Johnson, G.A. Virtual Neuropathology: A new approach to preclinical pathology using Magnetic Resonance Imaging Microscopy (1999). Spectroscopy 14(7) 17-22.

Herman, E.H., Zhang, J., Lipshultz, S., Rifai, N., Chadwick, D., Takedo, K., Yu, Z-X., Ferrans, V.J. Correlation between serum levels of cardiac troponin T and the severity of doxorubicin-induced cardiomyopathy. J.Clin. Oncol. 17(7):2237-2243, 1999.

Hirbert, S.L, Luna, R.E., Zhang, J., Wang, Y., Hopkins, R.A., Yu, Z.X., Ferrans, V.J. (1999) Allograft heart valves: the role of apoptosis-mediated cell loss. J. Thorac. Cardiovasc. Surg. 117 454-462.

Zhang, J., Andrade, Z.A., Andrade, S.G., Takeda, K., and Ferrans, V.J. (1999) Apoptosis in a canine model of acute Chagasic myocarditis. J. Mol. Cell Cardiol. 31 581-596.

Zhang, J., Duarte, C.G., Takeda, K., and Ellis, S. (1999) Contrast medium- and mannitol-induced apoptosis in heart and kidney of spontaneously hypertensive rats. Toxicol. Pathol. 27 427-435.

Duarte, G.G., Zhang, J., and Ellis, S. (1999) Effects of radiocontrast, mannitol, and endothelin on blood pressure and renal damage inthe aging male spontaneously hypertensive rat. Invest. Radiol. 34 455-462.

Whitehurst, V.E., Vick, J.A., Alleva, F.R., Zhang, J., Joseph, X., Balazs T. (1999) Reversal of propranolol blockade of adrenergic receptors and related toxicity with drugs that increase cyclic AMP. P.S.E.B.M. 221 382-385.

Duarte, C.G., Zhang, J., Ellis, S. (1999) Effects of radiocontrast, mannitol, and endothelin administration of blood pressure and renal damage in pentobarbital-anesthetized aging male SHR. Invest. Radiol. 24 450-462.

Zhou, Y-F., Shou, M., Gusther, E., Guzman, R., Unger, E.F., Yu, Z-X, Zhang, J., Finkel, T., Epstein, S.E. (1999) Cytomegalovirus infection of rats increases the neointimal response to vascular injury without consistent evidence of direct infection of the vascular wall. Circulation 100 1569-1575.

Halling KC, Lazzaro CR, Honchel R, Bufill JA, Powell SM, Arndt CAS, Lindor NM. (1999) A germline Alu repeat insertion of the APC gene leading to hereditary desmoid disease in an Amish famly. Human Heredity 49 97-102.

1998

Lester, D.S., Kidder L.H., Levin, I.R., and Lewis, E.N. Infrared microspectroscopic imaging fo the cerebellum of normal and drug treated rats. Cell. Mol. Biol. 44, 29-38 (1998).

Parchment RE, Gordon M, Grieshaber CK, Sessa C, Volpe DA, Ghielmini M. Predicting hematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests. Ann. Oncol. 9:357-364, 1998.

An Evaluation of the Hemizygous Transgenic TG.AC Mouse for Carcinogenicity Testing of Pharmaceuticals I. Evidence for a Confounding Nonresponder Phenotype. James L. Weaver, Joseph F. Contrera, Barry A. Rosenzweig, Karol L. Thompson, Patrick J. Faustino, John M. Strong, Christopher D. Ellison, Lawrence W. Anderson, Hullahalli R. Prasanna, Patricia E. Long-Bradley, Karl K. Lin, Jun Zhang, and Frank D. Sistare. Toxicol. Pathol. 26, 532-540 (1998).

An Evaluation of the Hemizygous Transgenic TG.AC Mouse for Carcinogenicity Testing of Pharmaceuticals II. Genotyping that Predicts Tumorigenic Responsiveness. Karol L. Thompson, Barry A. Rosenzweig, Frank D. Sistare. Toxicol. Pathol. 26, 548-555 (1998).

A semiautomated fluorescence-based cell-to-cell fusion assay for gp120-gp41 and CD4 expressing cells. P. Scott Pine, James L. Weaver, Tamas Oravecz, Marina Pall, Michael Ussery, and Adorjan Aszalos. Exp. Cell Res. 240 49-57 (1998).

Szekely, Z., Fabian, P., Torday, L.L., Michejda, C.J., Aszalos, A. Binding between the CD4 receptor and polysulfonated azo-dyes. An exploratory theoretical study on action-mechanism. J. Molec. Structure (Theochem) 423:153-159, 1998

Herman E.H., Lipshultz S.E., Rifai N., Zhang J., Papoian T., Yu Z., Takeda K., Ferrans V.J. Use of Troponin T levels as an indicator of doxorubicin-induced cardiotoxicity. Cancer Res. 58:195-197,1998

Hasinoff, B.B., Hellmann K., Herman E.H., Ferrans V.J. Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines. Current Med. Chem. 5:1-28,1998

Herman E.H., Ferrans V.J. Animal models of anthracycline cardiotoxicity:basic mechanisms and cardioprotective activity. Progr. Ped. Oncol. 8:49-58,1998

Herman E.H., Ferrans V.J. Preclinical models of cardiac protection from anthracycline-induced cardiotoxicity. Semin. Oncol. (In Press),1998

Herman E.H., Zhang J., Hasinoff B.B., Tran K.T., Chadwick D.P., Clark Jr J.R., Ferrans V.J. Comparison of the chronic toxicity of piroxantrone,losoxantrone and doxorubicin in spontaneously hypertensive rats. Toxicology (In Press),1998

Ferrans V.J., Clark Jr j.R., Zhang J., Yu Z.-X., Herman E.H. Pathogenesis and prevention of doxorubicin cardiomyopathy. Tsitolgia(Cytologia)Moscow (In Press),1998

1997

Inhibition of HIV infection of H9 cells by chlorpromazine derivitives. Indira Hewlwtt, Sherwin Lee, Josef Molnar, Sandor Foldeak, P. Scott Pine, James L. Weaver, and Adorjan Aszalos. J. Acq. Imm. Def. Synd. Hum. Retrovir. 15 16-20 (1997).

Considerations in assessing the immunotoxic potential of investigational drugs. Kenneth L. Hastings, Chang-Ho Ahn, Syed N. Alam, Adorjan Aszalos, Young S. Choi, John J. Jessop, and James L. Weaver. Drug Information J. 31 1357-1361 (1997).

Molnar, J., Hever, A., Fakla, I., Fischer, J., Ocscvski, I., and Aszalos, A. Inhibition of the transport functions of membrane proteins by some substituted phenothiazines in E. coli and multidrug resistant tumor cells. Anticancer Research 17 481-486, (1997).

Appel, N.M., Rapoport, S.I. and O'Callaghan, J.P. Sequelae of parenteral domoic acid administration in rats: regional effects on anatomical markers in brain. Synapse 25: 350-358, (1997).

Appel, N.M., Rapoport, S.I., O'Callaghan, J.P., Bell, J.M. and Freed, L.M. Sequelae of parenteral domoic acid administration in rats: regional effects on metabolic markers in brain. Brain Res. 754 55-64, (1997).

Appel, N.M. Classical and contemporary histochemical approaches for evaluating central nervous system microanatomy. Ann. N. Y. Acad. Sci. 820: 14-28, (1997) .

Lewis, E.N., Kidder, L.H., Levin, I.R., Kalasinsky, V.F., Hanig, J.P. and Lester, D.S. Applications of Fourier transform infrared imaging microscopy in neurotoxicity. Ann.N.Y.Acad.Sci. 820, 234-247 (1997).

Lyon, R.C., Lester, D.S., Hanig, J.P. Magnetic Resonance Spectroscopy of Perfused Brain Slices: Evaluation of Neuroprotective Agents.Proc. Int. Soc. Magn. Reson. Med . p. 1257 (1997) .

Duarte C.G., Zhang J., Ellis S. The SHR as a small animal model for radiocontrast renal failure. Relation of nephrotoxicity to animal's age, gender, strain and dose of radiocontrast. Renal Failure 19(6):723-743.1997

Herman E.H., Zhang J., Hasinoff B.B., Clark Jr J.R., Ferrans V.J. Comparison of the structural changes induced by doxorubicin and mitoxantrone in the heart, kidney and intestine and characterization of the Fe(III)-mitoxantrone complex. J.Mol.Cell. Cardiol. 29:2915-2930,1997

Herman E.H., Zhang J., Hasinoff B.B., Clark Jr J.R., Ferrans V.J. Comparison of the protective effects against chronic doxorubicin cardiotoxicity and the rates of Iron(III) displacement reactions of ICRF-187 and other bisdiketopiperazines. Cancer Chemoth. Pharmacol. 40:400-408,1997

Chiou TJ, Zhang J, Ferrans JV, Tzeng WF. (1997) Cardiac and renal toxicity of menadione in rat. Toxicology 124 193-202.

1996

Ahn C-H, Kong JY, Choi WC, Hwang MS. Selective inhibition of the effects of phorbol ester on doxorubicin resistance and P-glycoprotein by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) in multidrug-resistant MCF-7/Dox human breast carcinoma cells. Biochem. Pharmacol. 52:393-399, 1996.

Panyi G, Gaspar R, Krasznai Z, terHost JJ, Ameloot M, Aszalos A, Steel P, Damjanovich S. Immunosuppressors inhibit voltage-gated potassium channels in human peripheral blood lymphocytes. Biochem. Biophys Res. Commun. 221:254-258, 1996.

Hwang MS, Ahn C-H, Pine PS, Yin JJ, Hrycyna CA, Light T, Aszalos A. Effect of combination of suboptimal concentrations of P-glycoprotein blockers on the proliferation of mdr1 gene expressing cells. Int. J. Cancer. 65:389-397, 1996.

Weaver JL, McKinney L, Schoenlein PV, Goldenberg S, Gottesman MM, Aszalos A. MDR1/P-glycoprotein function. I. Effect of hypotonicity and inhibitors on rhodamine 123 exclusion. Am. J. Physiol. 270:C1447-1452, 1996

Weaver JL, Aszalos A, McKinney L. MDR1/P-glycoprotein function. II. Effect of hypotonicity and inhibitors on Cl- efflux and volume regulation. Am. J. Physiol. 270:C1453-1460, 1996.

Herman, E. H., Zhang, J., Chadwick, D.P., Ferrans, V.J. Age dependence of the cardiac lesions induced by minoxidil in the rat. Toxicology 110:71-83, 1996

Rodriquez, R., Hershey, J., Smith, L., Vick, J. Cross reactivity between bee venom and snake venom. Asthma and Immunology 52:18- , 1996

von Bredow, J., Vick, J., Lowenson, H., Adams, N. Pharmacological mechanisms of agents and toxins.Toxicon 34:325- , 1996

Whitehurst,V., Joseph, X., Vick, J., Zhang, J., and Balazs, T. Reversal of acute theophylline toxicity with calcium channel antagonists. Toxicology 110:113- ,1996

Rosenzweig, B.A., Hoskins, A., and Sistare, F.D., A Proposed In Vitro Cellular Insulin Assay to Replace the USP Bioidentity Test, Pharmacopeial Forum, 22, 3270-3287 (1996).

Schreurs, B.G. and Lester, D.S. High resolution fluorescent labeling of living cerebellar slices, Brain Res. 730: 125-132, 1996.

2. Book Chapters

2000

Lester, D.S. and Hanig, J. P. Purkinje cells: A significant target for neurotoxicity. In, Cellular and Molecular Mechanisms of Toxin Action, Vol. 4 (Lester, D.S, Slikker, W., Jr., Johannessen, J.P. and Lazarovici, P., eds.) Harwood Academic Publishers, (in press).

Lester, D.S., Slikker, Jr., W., and Lazarovici, P. Eds. Site-Specific Neurotoxicity. Cellular and Molecular Mechanisms of Toxin Action, Vol. 4. Harwood Academic Publishers, Lond. (in press).

Biomarkers of Toxicity and Surrogate Endpoints for Safety. Sistare, F.D., and Morrow, J.D., in Biomarkers and Surrogate Endpoints: Clinical Research and Applications, ed. G.J. Downing, Elsevier Scientific, Amsterdam, 2000, pp. 165-175.

1998

Estimation of Drug Resistance by Flow Cytometry. Adorjan Aszalos and James L. Weaver. in: Methods in Molecular Biology 91: Flow Cytometry Protocols. M.J. Jaroszeki and R. Heller eds. Humana Press, pp 117-122 (1998).

Estimation of Cell Viability by Flow Cytometry. James L. Weaver. in: Methods in Molecular Biology 91: Flow Cytometry Protocols. M.J. Jaroszeki and R. Heller eds. Humana Press, pp 77-83 (1998).

1997

Sistare, F.D., Anderson, L., Contrera, J.F., Cordaro, J.C., Ellison, C., Faustino, P., Grieshaber, C.K., Long-Bradley, P., Matthews, E., Prasanna, H.R., Rosenzweig, B., Strong, J., Thompson, K., and Weaver, J. "A Preliminary Evaluation of the TG.AC Transgenic Mouse Model for Carcinogenicity Testing," In: Molecular Toxicology: Utilization in Accelerated Drug Discovery and Chemical Safety Analysis, Gutry, P. and Savage, L. eds., IBC Library Series, pp 39 - 60 (1997).

Lester, D.S., Felder, C.C. and Lewis, E.N. Co-editors of Emerging Technologies in Brain Imaging. Ann. N.Y. Acad. Sc., 820.(1997)

1996

Aszalos A. Immunosuppressing agents as modulators of MDR in cancer - Preclinical studies. In Principles of Drug Development in Transplantation and Autoimmunity. Lieberman R, Mukherjee A, eds. New York, Chapman and Hall, pp741-747, (1996).

Lester, D.S. Mechanism of action of protein kinase C modulators. In, Cellular and Molecular Mechanisms of Toxin Action, Vol. 1 (Lazarovici, P. and Gutman, Y., eds.) Harwood Academic Publishers, pp.405-425, (1996).

3. Abstracts

2000

Rosenzweig, B.A., Honchel, R., Thompson, K.L., Strupczewski, C., Blanchard, K.T., Furst, S.M., Stoll, R.E., and Sistare, F.D. (2000) Further evidence for a palindromic orientation of transgene promoter sequence critical for tumorigenic responsiveness in Tg.AC transgenic mice. The Toxicologist 54 215.

Thompson, K.L., Broud, D.D., and Sistare, F.D. (2000) Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. The Toxicologist 54 215.

Weaver, J.L., de Saint-Denis, A., Swann, J., Armstrong, G., Hastings, K.L. (2000) Analysis of immune-related adverse events associated with therapeutic use of drugs. The Toxicologist 54 120.

Lester, D.S., Pine, P.S., David, H.D., Hanig, J.P. (2000) Innovative imaging approaches for detecting brain neurotoxicity. FASEB J. 14L A568.

Zhang, J., Herman E.H., Weaver, J.L., Chadwick, D.P., Broud, D., Rosenzweig, B.A., Knapton, A., Whitehurst, V., Sistare, F.D. (2000) Phosphodiesterase type III inhibitor induces vasculitis preceded by apoptosis in mesenteric vessels and lymphoid tissues in rats. The Toxicologist 54 347.

Herman, E.H., Zhang, J., Chadwick, D.P., Rifai, N., Lipshultz, S., Hasinoff, B., Ferrans, V.J. (2000) A comparison of the cardioprotective effects of dexrazoxone (DZR) against the cardiotoxicity induced by doxirubicin (DXR) and mitoxantrone (MTX) in spontaneously hypertensive rats. Proc. Am. Assn. Ca. Res..

1999

Thompson, K.L., Rosenzweig, B.A., Honchel, R.,, Blanchard, K.T., Stoll, R.E., and Sistare, F.D. (1999) Evidence of a palindromic orientation of transgene promoter sequence for tumorigenic responsiveness among Tg.AC transgenic mice. The Toxicologist 48 225.

Lester, D.S., Pine, P.S., Delnomdedieu, Johannessen, J.N. and Johnson, G.A. (1999) Virtual Neuropathology: 3-Dimensional Visualization and Quantitation of Lesions Due to Toxic Insult. Soc. Toxicol.Path. June, 1999.

Delaglio, F., Haka, A.S. and Lester, D.S., (1999) Multivariate Analysis of IR and NMR Data. SPIE, January, 2000.

Lyon, R.C., Lester, D.S., Johannessen, J.N., McGregor, G.N., Engelhardt, R.T. and Johnson, G.A. (1999) Assessment of Neurotoxicity in Rat Brain by Magnetic Resonance Microscopy. Proc. ISMRM.7:897.

Delnomdedieu, M., Appel, N.M., Pine, P.S., Hayakawa, T., Lester, D.S., and Johnson, G.A. (1999) MR Microscopy of Contrast-Structure in a Rat Model of Parkinson's Disease. Proc. ISMRM 7:450.

S. Ibrahim, A. Knapton, T. Licht, A. Aszalos. (1999) Influence of anti-psychotic, antiemetic and antifungal drugs on the function of P-glycoprotein in CACO-2 cells. ASPET, #PIII-90.

J.L. Weaver, D. Staten, K. Hastings. (1999) An evaluation of Guinea pig hypersensitivity tests for ability to detect systemic hypersensitivity potential of drugs. Toxicol. Sci. 48 1-S 316.

Herman E.H., Zhang, J., Lipshultz, S., Rifai, N., Takeda, K., Yu, Z-X., Chadwick, D.P., Ferrans, V.J. (1999) Cardiac troponin T (cTnT) as a biomarker for monitoring chronic doxirubicin (DXR) cardiomyopathy. J. Amer. Coll. Cardio. 33A 171a.

1998

Sistare, F.D., and Rosenzweig, B.A. Application of a Commercially Available In Vitro Stress Gene Assay as a Rapid Prescreen for Compound Selection to Test Specificity in the TG.AC Mouse Model. The Toxicologist 42 312, (1998).

Thompson K., Rosenzweig, B., and Sistare, F.D. Use of an In Vitro Transgene-Induction Assay as a Prescreen for Testing the Specificity of Pharmaceuticals in the TG.AC Mouse Short-term Carcinogenicity Assay. The Toxicologist 42 72, (1998).

Warren MK, Rose WL, Szabo JM, Volpe DA. Toxicity of chemotherapeutic agents in vitro: comparative effects on myeloid, erythroid and megakaryocyte lineages. Keystone Symposium, “Molecular Regulation of Platelet Production”, January 1998.

Faustino PJ, Volpe DA, Knapton AD, Ellison CD, Carver CA, Flora KP, Hussain AS. In vitro Caco-2 cell culture for predicting intestinal permeability of drugs: role of internal standards. First AAPS Frontier Symposium “From Good Ligands to Good Drugs: Optimizing Pharmaceutical Properties by Accelerated Screening”, February 19-21, 1998.

Herman E., Zhang J., Hasinoff B., Tran D., Chadwick D., Clark Jr J., Ferrans V. Comparison of the chronic toxicity of piroxantron(PXR), losoxantrone(LXR) and doxorubicin(DXR) in spontaneously hypertensive rats. The FASEB J. 12(4):A96,1998

Wang Y, Yu ZX, Zhang J, Detrick B, Hook JJ. (1998) Retinal apoptosis is associated with clearnace of infectious virus in coronavirus-infected retinopathy. Invest. Opthal. Vis. Sci. 39 S148.

1997

Volpe DA, Warren MK, Flora KP. In vitro prediction of time to neutropenic nadir. First International Symposium on Hematotoxicology in New Drug Development, June 1997.

Volpe DA. Myelotoxicity tests in preclinical development. First International Symposium on Hematotoxicology in New Drug Development, June 1997.

Thompson, K., Ahn, C.H., Williams, J., Pine, P.S., Yin, J.J. and Aszalos, A. Effect of multidrug resistance P-glycoprotein modulators in cancer chemotherapy on the function of the multidrug resistance associated protein, MRP. FDA Forum on Regulatory Sciences Abstr. J7 (1997).

P.J. Faustino, C.D. Ellison, B.A. Rosenzweig, K.P. Flora and J.L. Weaver. Plasma and Skin Levels of Chlorpheniramine Following Topical Application in Tg.AC Mice FDA Forum on Regulatory Sciences Abstract A15 (1997).

J.L. Weaver, C.D. Ellison, B.A. Rosenzweig and P.J. Faustino. Plasma and Skin Levels of Phenolphthalein and its Glucuronide Following Topical Application in TG.AC Mice. FDA Forum on Regulatory Sciences Abstract A33 (1997).

Barry Rosenzweig, Frank D. Sistare. Application of a Commercially Available In Vitro Stress Gene Assay as a Rapid Prescreen for Compound Selection to Test Specificity in the TG.AC Mouse ModelFDA Forum on Regulatory Sciences Abstract J5 (1997).

Karol Thompson, Barry Rosenzweig, and Frank D. Sistare. Use of an in vitro transgene-induction assay as a prescreen for evaluating the TG.AC mouse short-term carcinogenicity assay. FDA Forum on Regulatory Sciences Abstract J6, (1997).

Thompson,K., Ahn. C.H., Williams, J., Pine,P.S., Yin, J.J. and Aszalos, A. Effect of multidrug resistance P-glycoprotein modulators in cancer chemotherapy on the function of the multidrug resistance associated protein, MRP. FDA Forum on Regulatory Science. December 8, 1997

Pine, P.S., Ussery, M., Oravecz, T., Pall, M. and Aszalos,A. A fluorescence-based cell-to-cell fusion assay for HIV env and CD4 expressing cells. FDA Forum on Regulatory Science. December 8, 1997

Whitehurst V., Gudbjarnason S., Simental F., Joeseph X., Otulana B., Balazs T., Vick J. The effect of food restriction and rapid weight loss on fatty acid composition of phospholipids in heart muscle. Proc. Am. Thoracic Soc.15, 1997

Vick J., Whitehurst V., Alleva F., Zhang J., Chadwick D., Hinton D. Studies of pulmonary and cardiovascular changes in rats with hyper-reactive airways. Proceed. FDA Forum on Regulatory Sciences 77, 1997

Wang Y, Zhang J, Yu ZX, Detrick B, Hooks J. (1997) Retinal apoptosis in virus-induced retinopathy is associated with the acute infections disease and not with the late degenerative disease. Invest. Opthal. Vis. Sci. 38 S194.

1996

Aszalos A, Pine PS, Torday L. Influence of daunorubicin derivatives on cells transfected with MDR1 or MRP gene. FDA Forum on Regulatory Sciences, 1996, Abstr. A42.

Parchment RE, Machado S, Balch A, Long-Bradley PE, Faustino PJ, Volpe DA, Flora KP, Grieshaber CK. Lack of stimulation of murine tumor growth by antidepressants and antihistamines. Proc. AACR. 37:160, 1996 (abstract).

LoRusso PM, Wozniak A, Foster BM, Parchment RE, Volpe DA, Meyer M, Radulovic L, Corbett T, Valdivieso. Phase I trial of extended daily dosing of acetyldinaline (CI-994). 9th NCI-EORTC Symposium on New Drugs in Cancer Therapy. March 12-15, 1996, Amsterdam, p. 98 (abstract).

Thompson KL, Hwang MS. Ahn, C-H. Induction of p21/waf1 and apoptosis by an RXR-selective retinoid in human prostate cancer cells. Proc. AACR. 37:230, 1996 (abstract).

Torday L. Hrycyna CA, Ramachandra M, Hwang M, Ahn C-H, Gottesman MM, Aszalos A. Behavior of N-aceylated-daunorubicins in cells transfected with the mdr1 or mrp genes. Proc. AACR. 37:331, 1996 (abstract).

Volpe DA, LoRusso PM, Foster BM, Parchment RE. In vivo and in vitro toxicity of acetyldinaline (CI-994) to murine myelopoiesis and megakaryocytopoiesis. 9th NCI-EORTC Symposium on New Drugs in Cancer Therapy. March 12-15, 1996, Amsterdam, p. 115 (abstract).

Herman, E.H., Zhang, J., Chadwick, D.P., Ferrans, V.J. Comparison of the cardioprotective effect of WR 2721 and ICRF-187 on chronic doxorubicin(DXR) cardiotoxicity in spontaneously hypertensive rats(SHR). Proc Am. Assn. Cancer Res. 37:287, 1996

Herman, E.H., Lipshultz, S.E., Rifai, N., Zhang, J., Papoian, T., Yu, Z.-X., Ferrans, V. Cardiac troponin T: elevated serum levels and loss from cardiac myocytes in doxorubicin toxicity. Circulation 94(suppl.) : I-85, 1996

Russell, L., von Bredow, J., Vick, J. An in vitro system for evaluation of cyanide ions in studies with potential candidate antidotes. Animal Test Altternatives 99: 102, 1996

Vick, J., Whitehurst, V., Alleva, F., Zhang, J., Chadwick, D., Hinton, D. A model for studying pulmonary airway resistance and cardiovascular changes on genetically prone "asthmatic rats". J. Clin Pharmacol. 36:848, 1996

Whitehurst, V., Alleva, F., Vick, J., Zhang, J., Pestaner, J. A model for assessing drug effects on pulmonary and cardiovascular parameters in "asthmatic rats". Proc. Am. Thoracic Soc. 16: 47, 1996.

Zhang, J., Clark, Jr. J.R., Herman, E.H., Ferrans, V.J. Doxorubicin(DXR)- induced apoptosis in spontaneously hypertensive rats(SHR): differential effects in heart, kidney and intestine and inhibition by ICRF-187. Proc. Am. Assn. Cancer Res. 37:13, 1996

Sistare, F.D., Rosenzweig, B.A., Contrera, J.G., and Murgo, A.J., "Suramin Modulation of P2T Receptor Calcium Signaling in K562 and Dami Leukemia Cells," Proc. AACR, 37, 36 (1996).

Lyon, RC, Lester, DS, Hanig, JP: Magnetic Resonance Spectroscopy of Perfused Brain Slices: Potential for Evaluating Drug Neurotoxicity. Proc. Soc. Magn. Reson. p. 920, 1996.

Chickhale, E.G., Brady, D.R., Swyt, C.R., Gillen, G., Appel, N.M. and Smith, Q.R. Brain aluminum concentration: new low estimate and influence of contamination. Soc. Neurosci. Abstr. 22: 1922, 1996.

Smith, Q.R., Hokari, M., Aoyagi, M., Appel, N.M., Vannucci, S.J. and Simpsom, I.A. Blood-brain barrier glucose transport and the influence of diabetes and anesthesia. Soc. Neurosci. Abstr. 22: 909, 1996.