Testing Information

Testing Status of Agents at NTP

CAS Registry Number: 106-92-3 Toxicity Effects

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Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 1

Names (NTP)

  • Allyl glycidyl ether
  • ((2-PROPENYLOXY)METHYL)-OXIRANE (9CI)

Human Toxicity Excerpts

  • SEVERAL CASES OF DERMATITIS AND 1 CASE OF EYE IRRITATION CONSTITUTE THE HUMAN DATA. [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 20]**PEER REVIEWED**
  • Allyl glycidyl ether is a CNS depressant and also causes acute pulmonary edema. It is classified as slightly toxic after oral administration and percutaneous application, appreciably irritating and injurious to the eyes and skin, capable of causing skin sensitization in human subjects ... . [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2199]**PEER REVIEWED**
  • Short-term (acute): Exposure to AGE can cause moderate irritation of the skin and severe irritation of the eyes and respiratory tract. Long-term (chronic): Exposure to AGE can cause dermatitis with itching, swelling, and blisters. Skin sensitization to AGE and cross sensitization with other epoxy agents can also occur. [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. ]**PEER REVIEWED**
  • Dermal contact is the usual mode of exposure, but droplets in mist can also attack the eyes and respiratory tract. Glycidyl & diglycidyl ethers tend to be irritants and sensitizing agents. /Glycidyl & diglycidyl ethers/ [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-411]**PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ... CLASSIFIED AS A MODERATE PRIMARY SKIN IRRITANT AND SEVERE EYE IRRITANT. ... SYSTEMIC TOXICITY TO RATS WAS OBSERVED AFTER 50 DAILY, 7 HOUR EXPOSURES AT 260, 400 AND 900 PPM, MANIFESTED BY INCREASED WEIGHT GAIN AT 260 PPM, AND HIGH MORTALITY AT 600 AND 900 PPM. [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 20]**PEER REVIEWED**
  • KIDNEYS OF ... /RATS/ EXPOSED TO 400 PPM /50 DAYS/ ... EXCESSIVE KIDNEY-BODY WT RATIOS. 260 PPM ... VERY SLIGHT IRRITATION OF EYES & SLIGHT RESPIRATORY DISTRESS. AT HIGHER LEVELS CORNEAL OPACITIES ... & SEVERE RESPIRATORY DIFFICULTIES. ... AUTOPSY SHOWED BRONCHOPNEUMONIA, EMPHYSEMA, BRONCHIECTASIS, PNEUMONITIS & HEMORRHAGE. [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 20]**PEER REVIEWED**
  • AT LEVELS HIGHER THAN 260 PPM AUTOPSY OF RATS EXPOSED 50 DAYS REVEALED: ... MOTTLED DISCOLORATION OF THE LIVER & ENLARGED ADRENAL GLANDS. 2 ANIMALS EXPOSED TO 900 PPM HAD NECROTIC SPLEENS. ... PREDOMINANT TOXICOLOGIC ACTIVITY WAS DEPRESSION OF CNS AFTER INTRAGASTRIC ADMINISTRATION. [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 20]**PEER REVIEWED**
  • ADMIN TO MICE & RATS ORALLY PRODUCED MODERATE DEPRESSION & DYSPNEA WITHIN 15-19 MIN. DEATH OCCURRED IN 4 HR TO 5 DAYS. ... @ AUTOPSY HYPOTONICITY OF ENTERIC TRACT & EXTENSIVE ADHESIONS OF STOMACH WALLS TO ADJACENT TISSUES WERE NOTED. NO CHARACTERISTIC MICROSCOPIC PATHOLOGY OCCURRED ... . [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2199]**PEER REVIEWED**
  • ADMIN TO RATS & MICE ORALLY, DEATH IN 4 HR-5 DAYS: ... AT AUTOPSY ... OCCASIONALLY THE LIVER SHOWED FOCAL AREAS OF NECROSIS. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2199]**PEER REVIEWED**
  • PERCUTANEOUS ABSORPTION. DEPRESSION OCCURRED PROGRESSIVELY DURING THE 7 HR OF CONTACT. ... NECROPSY SHOWED CONSTRICTED KIDNEYS & SPLEENS. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2199]**PEER REVIEWED**
  • VAPOR EXPOSURES. ... MICE & RATS SHOWED SEVERE IRRITATION OF THE EYES & RESPIRATORY TRACT ACCOMPANIED BY LACRIMATION & SALIVATION, DYSPNEA & SEVERE GASPING & GASEOUS DISTENTION OF THE ABDOMEN. ... CORNEAL OPACITIES OCCURRED IN RATS. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2199]**PEER REVIEWED**
  • TESTICULAR ATROPHY AND HEMOPOIETIC ABNORMALITIES WERE OBSERVED IN LAB ANIMALS (RAT, RABBIT, DOG) AFTER EXPOSURE TO ALLYL GLYCIDYL ETHER. [LANE JM; VET HUM TOXICOL 22 (2): 99 (1980)]**PEER REVIEWED**
  • MUTAGENICITY WAS EVALUATED BOTH WITH AND WITHOUT ADDITION OF RAT LIVER MICROSOMAL EXTRACT. ALLYL GLYCIDYL ETHER WAS MUTAGENIC IN TA100 STRAIN, CAUSING REVERSION OF BACTERIA TO HISTIDINE INDEPENDENCE. [WADE MJ ET AL; MUTAT RES 66 (4): 367 (1979)]**PEER REVIEWED**
  • Rat: 400 mg/kg im injections on days 1, 2, 8, & 9; animals sacrificed on day 12; focal necrosis of the testes in 1 of 2 of the 3 surviving rats, atrophy or loss of lymphoid tissue in 2 of 3 rats, decreased leukocyte count. [Verschueren, K. Handbook of Environmental Data of Organic Chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983., p. 180]**PEER REVIEWED**
  • Allyl glycidyl ether causes severe but reversible corneal damage when dropped on a rabbits eye. High vapor concentration produces corneal opacities in rats. [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 70]**PEER REVIEWED**
  • In mice and rats, acute inhalation or oral administration of AGE caused tearing, nasal discharge, dyspnea (breathing difficulty), ... and death (due to pulmonary edema and central nervous system depression); acute intramuscular injection in rats produced testicular degeneration and toxic effects on the hematopoietic (blood-cell-forming) systems, including decreased leukocyte counts and atrophy of lymphoid tissue. Subchronic inhalation AGE by rats caused central nervous system depression, reduction in weight gain, corneal opacity, pneumonia, emphysema, and enlarged adrenal glands. AGE was mutagenic in bacterial test systems ... [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. ]**PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LD50 Rabbit percutaneous 2.55 g/kg [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2199]**PEER REVIEWED**
  • LC50 Mouse inhalation 270 ppm/4 hours [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 20]**PEER REVIEWED**
  • LC50 Rat inhalation 670 ppm/8 hr [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 20]**PEER REVIEWED**
  • LD50 Mouse intragastric 0.39 g/kg [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 20]**PEER REVIEWED**
  • LD50 Rat intragastric 1.60 g/kg [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 20]**PEER REVIEWED**

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Absorption, Distribution and Excretion

  • None found

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Metabolism/Metabolites

  • None found

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TSCA Test Submissions

  • The mutagenicity of allyl glycidyl ether (AGE) was evaluated in Salmonella tester strains TA98 and TA1535, both in the presence and absence of added metabolic activation by either Aroclor-induced or phenobarbitol-induced rat liver S9 fraction. AGE was tested for mutagenicity at concentrations of 0.5, 1.0 and 2.0 micromoles/plate using the plate incorporation method. AGE caused a positive response in tester strain 1535 at 2.0 micromoles/plate in the presence of metabolic activation by Aroclor-induced rat liver S9 fraction.[University of Texas Medical Branch; Final Report on the Epoxides Evaluated for Mutagenicity. (1977), EPA Document No. 878211534, Fiche No. OTS0206138 ]**UNREVIEWED**
  • The effect of allyl glycidyl ether was examined in the DNA repair assay. Human mononucleated white cells in G-0 phase were exposed to 1, 10, 100 or 500 ppm test article (dissolved in DMSO) for 5 hours. Exposure at any concentration did not statistically significantly (Duncan's LSD test, p > 0.05) increase the number of grains per nucleus counted on autoradiographs, or increase the intracellular incorporation of tritiated thymidine measured by liquid scintillation counting. In a preliminary range finding test, toxicity was reported at the upper dose levels used in the definitive test.[ University of Texas Medical Branch at Galveston; Report to the Dow Chemical Company Integrated Mutagenicity Testing Program (1977), EPA Document No. 878211534, Fiche No. OTS0206138 ]**UNREVIEWED**
  • The mutagenicity of allyl glycidyl ether (AGE) was evaluated in male B6D2F1 mice (at least 10) dermally exposed to GBE at a dose level of 1.5 g/kg three times/week for a minimum of 8 weeks. Following the treatment period, the male mice were mated with 3 untreated, virgin female B6D2F1f mice for one week and mated with 3 fresh females for a second week. Significant differences were observed between treated and control mice in the following: proportion of deaths/pregnancy (decreased throughout the study). Significant differences were observed between treated mice over time in the following: number of implants/pregnancy (decreased versus controls in 1st week post-treatment, decreased versus controls in 2nd week post-treatment). There were no differences between treated and control mice or in treated mice over time with respect to percent pregnancy.[University of Texas Medical Branch; Final Report on the Epoxides Evaluated for Mutagenicity. (1977), EPA Document No. 878211534, Fiche No. OTS0206138 ]**UNREVIEWED**

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Footnotes

1 Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.

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Web page last updated on May 14, 2008