LOCUS NP_776684 716 aa linear MAM 21-DEC-2008
DEFINITION calpain 1, large subunit [Bos taurus].
ACCESSION NP_776684 XP_615535
VERSION NP_776684.1 GI:27806281
DBSOURCE REFSEQ: accession NM_174259.2
KEYWORDS .
SOURCE Bos taurus (cattle)
ORGANISM Bos taurus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
REFERENCE 1 (residues 1 to 716)
AUTHORS Averna,M., Stifanese,R., De Tullio,R., Passalacqua,M., Salamino,F.,
Pontremoli,S. and Melloni,E.
TITLE Functional role of HSP90 complexes with endothelial nitric-oxide
synthase (eNOS) and calpain on nitric oxide generation in
endothelial cells
JOURNAL J. Biol. Chem. 283 (43), 29069-29076 (2008)
PUBMED 18682401
REMARK GeneRIF: the protective effect exerted by HSP90 on eNOS degradation
mediated by calpain represents a novel and critical mechanism that
assures the reversibility of the intracellular trafficking and
activation of the synthase
REFERENCE 2 (residues 1 to 716)
AUTHORS Cheong,H.S., Yoon,D.H., Park,B.L., Kim,L.H., Bae,J.S., Namgoong,S.,
Lee,H.W., Han,C.S., Kim,J.O., Cheong,I.C. and Shin,H.D.
TITLE A single nucleotide polymorphism in CAPN1 associated with marbling
score in Korean cattle
JOURNAL BMC Genet. 9, 33 (2008)
PUBMED 18423040
REMARK GeneRIF: polymorphisms in CAPN1 might be one of the important
genetic factors involved in carcass quality in beef cattle
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 716)
AUTHORS Barendse,W., Harrison,B.E., Hawken,R.J., Ferguson,D.M.,
Thompson,J.M., Thomas,M.B. and Bunch,R.J.
TITLE Epistasis between calpain 1 and its inhibitor calpastatin within
breeds of cattle
JOURNAL Genetics 176 (4), 2601-2610 (2007)
PUBMED 17603104
REMARK GeneRIF: direct measurement of epistatic interactions of causative
mutations for quantitative trait loci (QTL) at calpain 1 (CAPN1),
located on chromosome 29, with causative mutations for QTL
variation at calpastatin (CAST), located on chromosome 7
REFERENCE 4 (residues 1 to 716)
AUTHORS Raynaud,F., Jond-Necand,C., Marcilhac,A., Furst,D. and Benyamin,Y.
TITLE Calpain 1-gamma filamin interaction in muscle cells: a possible in
situ regulation by PKC-alpha
JOURNAL Int. J. Biochem. Cell Biol. 38 (3), 404-413 (2006)
PUBMED 16297652
REMARK GeneRIF: Data show that gamma-filamin formed a stable complex in
vitro and in cells with calpain 1 in the absence of calcium
stimulation.
Erratum:[Int J Biochem Cell Biol. 2006;38(7):1230. Fabrice, Raynaud
[corrected to Raynaud, Fabrice]; Carole, Jond-Necand [corrected to
Jond-Necand, Carole]; Anne, Marcilhac [corrected to Marcilhac,
Anne]; Dieter, Furst [corrected to Furst, Dieter]; Yves, Benyamin
[corrected to Benyamin, Yves]]
REFERENCE 5 (residues 1 to 716)
AUTHORS Raynaud,F., Fernandez,E., Coulis,G., Aubry,L., Vignon,X.,
Bleimling,N., Gautel,M., Benyamin,Y. and Ouali,A.
TITLE Calpain 1-titin interactions concentrate calpain 1 in the Z-band
edges and in the N2-line region within the skeletal myofibril
JOURNAL FEBS J. 272 (10), 2578-2590 (2005)
PUBMED 15885106
REMARK GeneRIF: Data show that calpain I is located at the periphery of
the Z-band and at the midpoint of the I-band in skeletal muscle
myofibrils.
REFERENCE 6 (residues 1 to 716)
AUTHORS Juszczuk-Kubiak,E., Sakowski,T., Flisikowski,K., Wicinska,K.,
Oprzadek,J. and Rosochacki,S.J.
TITLE Bovine mu-calpain (CAPN1) gene: new SNP within intron 14
JOURNAL J. Appl. Genet. 45 (4), 457-460 (2004)
PUBMED 15523157
REFERENCE 7 (residues 1 to 716)
AUTHORS Raynaud,F., Bonnal,C., Fernandez,E., Bremaud,L., Cerutti,M.,
Lebart,M.C., Roustan,C., Ouali,A. and Benyamin,Y.
TITLE The calpain 1-alpha-actinin interaction. Resting complex between
the calcium-dependent protease and its target in cytoskeleton
JOURNAL Eur. J. Biochem. 270 (23), 4662-4670 (2003)
PUBMED 14622253
REMARK GeneRIF: investigation of calpain 1 binding with alpha-actinin;
propose that calpain 1 interacts in a resting state with
cytoskeletal targets
REFERENCE 8 (residues 1 to 716)
AUTHORS Heaton,M.P., Harhay,G.P., Bennett,G.L., Stone,R.T., Grosse,W.M.,
Casas,E., Keele,J.W., Smith,T.P., Chitko-McKown,C.G. and
Laegreid,W.W.
TITLE Selection and use of SNP markers for animal identification and
paternity analysis in U.S. beef cattle
JOURNAL Mamm. Genome 13 (5), 272-281 (2002)
PUBMED 12016516
REFERENCE 9 (residues 1 to 716)
AUTHORS Smith,T.P., Casas,E., Rexroad,C.E. III, Kappes,S.M. and Keele,J.W.
TITLE Bovine CAPN1 maps to a region of BTA29 containing a quantitative
trait locus for meat tenderness
JOURNAL J. Anim. Sci. 78 (10), 2589-2594 (2000)
PUBMED 11048924
REFERENCE 10 (residues 1 to 716)
AUTHORS Zimmerman,U.J. and Schlaepfer,W.W.
TITLE Two-stage autolysis of the catalytic subunit initiates activation
of calpain I
JOURNAL Biochim. Biophys. Acta 1078 (2), 192-198 (1991)
PUBMED 2065086
REMARK Erratum:[Biochim Biophys Acta. 1991 Nov 15;1080(3):275. PMID:
1954235]
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF221129.1.
On Mar 29, 2005 this sequence version replaced gi:61827747.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..716
/organism="Bos taurus"
/db_xref="taxon:9913"
/chromosome="29"
/map="29"
Protein 1..716
/product="calpain 1, large subunit"
/EC_number="3.4.22.52"
/note="micromolar calcium activated neutral protease 1;
micromolar calcium-activated neutral protease 1"
/calculated_mol_wt=82077
Region 44..352
/region_name="CysPc"
/note="IIb; calcium-dependent cytoplasmic cysteine
proteinases, papain-like. Functions in cytoskeletal
remodeling processes, cell differentiation, apoptosis and
signal transduction; cd00044"
/db_xref="CDD:28925"
Site order(115,272,296)
/site_type="other"
/note="catalytic site"
/db_xref="CDD:28925"
Region 364..526
/region_name="Calpain_III"
/note="Calpain, subdomain III. Calpains are
calcium-activated cytoplasmic cysteine proteinases,
participate in cytoskeletal remodeling processes, cell
differentiation, apoptosis and signal transduction.
Catalytic domain and the two calmodulin-like domains...;
cd00214"
/db_xref="CDD:29269"
Site order(402..404,419)
/site_type="other"
/note="acidic loop"
/db_xref="CDD:29269"
Region 592..646
/region_name="EFh"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading...;
cd00051"
/db_xref="CDD:28933"
Site order(600,602,604,611,630,632,634,641)
/site_type="other"
/note="Ca2+ binding site"
/db_xref="CDD:28933"
Region 619..>711
/region_name="FRQ1"
/note="Ca2+-binding protein (EF-Hand superfamily) [Signal
transduction mechanisms / Cytoskeleton / Cell division and
chromosome partitioning / General function prediction
only]; COG5126"
/db_xref="CDD:34727"
CDS 1..716
/gene="CAPN1"
/coded_by="NM_174259.2:78..2228"
/db_xref="GeneID:281661"
ORIGIN
1 maeefitpvy ctgvsaqvqk qrakelglgr henaikylgq dyeqlrvhcl qrgalfrdea
61 fppvpqslgf kelgpnsskt ygikwkrpte lfsnpqfivd gatrtdicqg algdcwllaa
121 iasltlndtl lhrvvphgqs fqdgyagifh fqlwqfgewv dvvvddllpt kdgklvfvhs
181 aqgnefwsal lekayakvng syealsggst segfedftgg vtewyelrka psdlyniilk
241 alergsllgc sidissildm eavtfkklvk ghaysvtgak qvnyqgqmvn lirmrnpwge
301 vewtgawsdg ssewngvdpy mreqlrvkme dgefwmsfrd fmreftrlei cnltpdalks
361 qrfrnwnttl yegtwrrgst aggcrnypat fwvnpqfkir leetddpdpd dyggresgcs
421 fllalmqkhr rrerrfgrdm etigfavyev ppelmgqpav hlkrdfflsn asrarseqfi
481 nlrevstrfr lppgeyvvvp stfepnkegd fvlrffseks agtqelddqv qanlpdeqvl
541 seeeidenfk slfrqlaged meisvkelrt ilnriiskhk dlrttgfsle scrsmvnlmd
601 rdgngklglv efnilwnrir nylsifrkfd ldksgsmsay emrmaiefag fklnkklyel
661 iitrysepdl avdfdnfvcc lvrletmfrf fktldtdldg vvtfdlfkwl qltmfa
//