Energy Citations Database

Bibliographic Citation

 
Document
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title Phtoactivation of polynuclear hydrocarbons
Creator/Author Epstein, S.S.
Publication Date1965 Feb 01
OSTI IdentifierOSTI ID: 6667503
Other Number(s)CODEN: AEHLA
Resource TypeJournal Article
Resource RelationArch. Environ. Health ; Vol/Issue: 10
Subject560304 -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987) ;500200 -- Environment, Atmospheric-- Chemicals Monitoring & Transport-- (-1989); ;AIR POLLUTION-- BIOLOGICAL EFFECTS;POLYCYCLIC AROMATIC HYDROCARBONS-- PHOTOCHEMISTRY;POLYCYCLIC AROMATIC HYDROCARBONS-- TOXICITY; BIOASSAY;CARCINOGENS;HEALTH HAZARDS;PARAMECIUM
Related SubjectANIMALS;AROMATICS;CHEMISTRY;CILIATA;HAZARDS;HYDROCARBONS;INVERTEBRATES;MICROORGANISMS;ORGANIC COMPOUNDS;POLLUTION;PROTOZOA
Description/Abstract This review presented some incomplete studies with these objectives: (1) to study photodynamic mechanisms as a parameter of activity of polynuclear carcinogens; (2) to determine the nature of the correlation existing between photodynamic and carcinogenic activities in the class of polynuclear compounds; and (3) to determine whether the degree of photodynamic activity of crude organic mixtures, such as air pollutants, could provide a useful and rapid measure of presumptive carcinogenic hazard to man, attributable to polynuclear compounds.^Log-phase cells of cloned cultures of Paramecium caudatum, grown axenically in the dark at 28/sup 0/C in a semi-synthetic medium of low protein content, provided the standard source of test cells.^The limited data presented suggested that bioassay may provide a biological index of potential carcinogenic hazard attributable to polycyclic compounds.^However, evaluation of this concept demands correlated photodynamic, carcinogenic, and chemical studies on numerous samples and fractions of organic air pollutants collected from sources exemplifying a wide epidemiological spectrum of respiratory tract cancer.^24 references, 5 figures, 2 tables.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 233-239
System Entry Date2001 May 13

Top