Bibliographic Citation
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Title | Phtoactivation of polynuclear hydrocarbons |
Creator/Author | Epstein, S.S. |
Publication Date | 1965 Feb 01 |
OSTI Identifier | OSTI ID: 6667503 |
Other Number(s) | CODEN: AEHLA |
Resource Type | Journal Article |
Resource Relation | Arch. Environ. Health ; Vol/Issue: 10 |
Subject | 560304 -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987) ;500200 -- Environment, Atmospheric-- Chemicals Monitoring & Transport-- (-1989); ;AIR POLLUTION-- BIOLOGICAL EFFECTS;POLYCYCLIC AROMATIC HYDROCARBONS-- PHOTOCHEMISTRY;POLYCYCLIC AROMATIC HYDROCARBONS-- TOXICITY; BIOASSAY;CARCINOGENS;HEALTH HAZARDS;PARAMECIUM |
Related Subject | ANIMALS;AROMATICS;CHEMISTRY;CILIATA;HAZARDS;HYDROCARBONS;INVERTEBRATES;MICROORGANISMS;ORGANIC COMPOUNDS;POLLUTION;PROTOZOA |
Description/Abstract | This review presented some incomplete studies with these objectives: (1) to study photodynamic mechanisms as a parameter of activity of polynuclear carcinogens; (2) to determine the nature of the correlation existing between photodynamic and carcinogenic activities in the class of polynuclear compounds; and (3) to determine whether the degree of photodynamic activity of crude organic mixtures, such as air pollutants, could provide a useful and rapid measure of presumptive carcinogenic hazard to man, attributable to polynuclear compounds.^Log-phase cells of cloned cultures of Paramecium caudatum, grown axenically in the dark at 28/sup 0/C in a semi-synthetic medium of low protein content, provided the standard source of test cells.^The limited data presented suggested that bioassay may provide a biological index of potential carcinogenic hazard attributable to polycyclic compounds.^However, evaluation of this concept demands correlated photodynamic, carcinogenic, and chemical studies on numerous samples and fractions of organic air pollutants collected from sources exemplifying a wide epidemiological spectrum of respiratory tract cancer.^24 references, 5 figures, 2 tables. |
Country of Publication | United States |
Language | English |
Format | Pages: 233-239 |
System Entry Date | 2001 May 13 |
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