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pfam01582: TIR, with user query added  
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TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Statistics
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PSSM-Id: 65386
View PSSM: pfam01582
Aligned: 42 rows
Created: 26-Apr-2007
Updated: 7-May-2007
Structure
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Program:
Drawing:
Aligned Rows:
pfam01582 is not assigned to any domain superfamily.
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FYV_A        15 AFISYSG-----------HDSFW-VKNELLPNLEke--gXQICLHERNFVPGKSIVENiITC-IEKSYKSIFVLSPNFVQ 79
query          1 -----------------sRNIXYdAFVSYSERDAyw--vENLX--VQELENFNPPFKL-XLHkRDFIPGKWIIDNIIDSI 58
gi 75217062   14 VFASFHGp----------DVRKS-FLSHFRKQFIcn--gITMFDDQK-IVRSQTIAPS-LTQgIRESKISIVILSKNYAS 78
gi 75220104   11 VFISFRGk----------DERNG-LLTLLKQKLIdg--nVNVFTDDK--LTG-QPLQN-LFGhIRKSRIAIVIFSKNYAE 73
gi 75223225   17 VFINFRGe----------EIRYS-FLSHLAAAFElh--gINFFIDKD-EQKG-KDLKH-LFKrIKQSQIALAIFSERYAE 80
gi 75099462   21 VFLNFRGk----------QLRNG-FVSHLEKALRrd--gINVFIDRN-ETKG-RDLSN-LFSrIQESRIALAIFSSMYTE 84
gi 75098740   17 VFLNFRGd----------ELRNN-FVSHLDKALRgk--qINVFIDEA-VEKG-ENLDN-LFKeIEKSRIALAIISQKYTE 80
gi 75219620  511 VVFINHGe---------sDQSDG-FIRHVERALNde--gFNVFIDSD-ERRG-RGMEH-IFRaIDNSNVALVIFSDRYTA 575
gi 74762124  410 AFVSYAKwssfpseatssLSEEH-LALSLFPDVLenkygYSLCLLERDVAPGGVYAED-IVSiIKRSRR-GIFILSPNYV 486
gi 34222652  407 IYVSYARn----------AEEEE-FVLLTLRGVLenefgYKLCIFDRDSLPGGIVTDE-TLSfIQKSRR-LLVVLSPNYV 473
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FYV_A        80 SEw--cHYELYFAHHNLFHEgsNSLILILLEPIPQYSIPssYHKLKSLXARRTYLEWPKEK----------SKRGLFWAN 147
query         59 EKs--hKTVFVLSENFVKSEwxKYELDFSHFRLFDENND--AAILILL--EPIEKKAIPQR----------FXKLRKIXN 122
gi 75217062   79 STw--cLNELLEILKCREDIg--QIVMTVFYGVDPSDVR--KQTGEFGTVFNKTCA---RRt---------eKERRNWSQ 140
gi 75220104   74 SGw--cLDELVEIKKCFETEa-LKAVIPIFHRVKVSSVK--KQSGKFGEKFLALQNYLLAEevdkkkikriNSRIKRWKK 148
gi 75223225   81 SPw--cLNELAKMKKLAKKg--KLNVVPIFYKVEVNDVR--HQEGKFGSNFWKLAKISSGDe------------IKKWKE 142
gi 75099462   85 SYw--cLDELVKIKDCVDLg--TLVVIPIFYMVDTDDVK--NLKGAFGYTFWKLAKTCNGEk------------LDKWKQ 146
gi 75098740   81 SKw--cLNELVKMKELEg----KLVTIPIFYNVEPATVR--YQKEAFGAALTKTQENDSDGq------------MKKWKE 140
gi 75219620  576 SEl--cLHEAVRIYDRRREg--KLVLIPVFYRVSEDDVN--MFNGRFGESFLETLTIQGFRd------------HPFAEH 637
gi 74762124  487 NGp--sIFELQAAVNLALDDqtLKLILIKFCYFQEPESLp--HLVKKALRVLPTVTWRGLKs--------vPPNSRFWAK 554
gi 34222652  474 LQgtqaLLELKAGLENMASRgnINVILVQYKAVKETKVK----ELKRAKTVLTVIKWKGEKs--------kYPQGRFWKQ 541

                 ....
1FYV_A       148 LRAA 151
query        123 TKTY 126
gi 75217062  141 ALNV 144
gi 75220104  149 ALKI 152
gi 75223225  143 ALEF 146
gi 75099462  147 ALKD 150
gi 75098740  141 ALTY 144
gi 75219620  638 WMRN 641
gi 74762124  555 MRYH 558
gi 34222652  542 LQVA 545
Citing CDD
Marchler-Bauer A, Anderson JB, Derbyshire MK, DeWeese-Scott C, Gonzales NR, Gwadz M, Hao L, He S, Hurwitz DI, Jackson JD, Ke Z, Krylov D, Lanczycki CJ, Liebert CA, Liu C, Lu F, Lu S, Marchler GH, Mullokandov M, Song JS, Thanki N, Yamashita RA, Yin JJ, Zhang D, Bryant SH. (2007) CDD: a conserved domain database for interactive domain family analysis. Nucleic Acids Res. 35: D237-40
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