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 Thursday, December 20, 2007 Volume 19   Number 24
update banner Family History Population Research Genomics in Practice General Public
Happy Holidays
CDC's National Office of Public Health Genomics will not be publishing or sending the Genomics and
Health Weekly Update next week. The NOPHG staff wish you a wonderful holiday season!
This weekly update provides information about the impact of human genetic research on disease prevention & public health. open mailbox for email deliveryGet email updates
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blue dotScientific Literature
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 Upcoming Events

10th Year Anniversary of Public Health Genomics at CDC

Genomics and Clinical Microbiology  non-gov warning icon

6th Workshop: Statistical methods for post-genomic data  non-gov warning icon



 Let's Go Surfing

Genome Québec  non-gov warning icon

Howard University’s National Human Genome Center  non-gov warning icon

Microarray Tools


CDC Celebrates 10 Years of Public Health Genomics - January 23, 2008
EGAPP logo

The independent EGAPP Working Group released the first in a planned series of recommendation statements on the use of genetic tests in clinical practice. This first statement addresses the use of cytochrome P450 (CYP450) testing in adults with depression treated with a widely prescribed class of antidepressants. The recommendation statement appears in the December issue of Genetics in Medicine, and is accessible through the EGAPP Working Group non-gov warning icon Web site.

> Read more about the EGAPP initiative
> Read CDC Press Statement

Genomics Announcements
 
CDC sponsored material
CDC's National Office of Public Health Genomics announces a new funding opportunity for those interested in genomics translation research.
   
CDC sponsored material
CDC's National Office of Public Health Genomics is looking for a new health services researcher. For more information about the position, click on the U.S. Department of Health and Human Services website non-gov warning icon and enter the vacancy number (HHS-CDC-T2-2008-0091 – for current employees or HHS-CDC-D2-2008-0054 – for non-federal applicants). The deadline to apply is January 2, 2008.
 
CDC sponsored material

The Genomics Forum of the American Public Health Association is soliciting abstracts for the 2008 Annual Meeting and Exposition on October 25-29, 2008, in San Diego, California.

   
CDC sponsored material
HuGENet™ What's New
December 2007
   


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

Researchers initiate gene therapy trial in patients with advanced skin cancer, non-gov warning icon News-Medical.Net, December 19

The International Myeloma Foundation identifies potential link between genetic pathways and environmental risks for myeloma, non-gov warning icon Medical News Today, December 13

Bowel cancer genes that triple risk discovered, non-gov warning icon News-Medical.Net, December 17

Most carriers of Fanconi anemia genes are not at a higher risk of cancer, non-gov warning icon News-Medical.Net, December 13

Herceptin helps women with multiple chromosomes containing HER2 gene, non-gov warning icon Medical News Today, December 15

 

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Cardiovascular Disease

Heart attack risk from smoking due to genetics, non-gov warning icon Medical News Today, December 20

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Diabetes

Worldwide children's diabetes study begins, non-gov warning icon United Press International, December 17

$1.7 million grant to advance understanding of genetic influences on diabetes, non-gov warning icon News-Medical.Net, December 13

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Ethical, Legal and Social Issues (ELSI)

'Informed cohort' provides personal stake in genetics research, non-gov warning icon News-Medical.Net, December 13

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Family History

A family health portrait, non-gov warning icon Syracuse.com, December 18

Family gene puts men at risk for breast cancer, non-gov warning icon ABC News, December 14

Your family medical history may save your child's life, non-gov warning icon Imperial Valley News, December 16

Spotting family health risks could result in a life saving gift, non-gov warning icon Blackanthem.com, December 14

Men unaware of their risk of cancer when female family members test positive for cancer causing gene mutation, non-gov warning icon Medical News Today, December 15

 

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Genetic Testing
Evidence Doesn't Support CYP450 Gene Testing before Antidepressant Treatment, non-gov warning icon Newswise, December 19

As gene tests spread, questions follow, non-gov warning icon Wall Street Journal, December 13

Emory, Ohio State launch partnership in predictive and personalized health care, non-gov warning icon EurekAlert, December 18

Carbamazepine prescribing information to include recommendation of genetic test for patients with Asian ancestry, non-gov warning icon Medical News Today, December 14

Gene test can indicate whether Tamoxifen can fight breast cancer, non-gov warning icon ABC News, December 17

 

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Other News
NIH launches Human Microbiome Project, non-gov warning icon NIH News, December 19

Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease, non-gov warning icon News-Medical.Net, December 17

Association discovered between genes regulating glucose metabolism and Spina Bifida, non-gov warning icon Medical News Today, December 19

International research collaboration narrows focus on genetic cause of Kawasaki disease, non-gov warning icon EurekAlert, December 16

Discovery of new ALS gene, non-gov warning icon News-Medical.Net, December 19

Groundbreaking genome project to be piloted by BGSU undergraduates, non-gov warning icon Medical News Today, December 15

Twin study indicates genetic basis for processing faces, places, non-gov warning icon Medical News Today, December 19

Panning the region for genetic gold, non-gov warning icon The Chronicle Herald, December 15

Boy living in bubble develops leukemia from experimental therapy, non-gov warning icon Fox News, December 18

Trendspotter: Gene scene, non-gov warning icon FT.com, December 15

New hope for sleep disorders: Genetic switch for circadian rhythms discovered, non-gov warning icon Science Daily, December 18

Agency approves drug to treat genetic disorder that can lead to retardation, non-gov warning icon The New York Times, December 14

Quebec announces register to add genetic typing to blood transfusions, non-gov warning icon (last accessed 2/2008) CBC News, December 18

Genetics may boost Mexican-Americans' risk for alcoholism, non-gov warning icon Washington Post, December 13

Mutation in one gene tied to Lou Gehrig's
disease
, non-gov warning icon Reuters Health, December 17

 
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Genomics in Scientific Literature
Featured Item

Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies
Takata Y, et al.
J Hum Genet 2007 Dec

 General Articles

Clustered Environments and Randomized Genes: A Fundamental Distinction between Conventional and Genetic Epidemiology
Smith GD, et al.
PLoS Med 2007 Dec;4(12):e352

Retention of African American women in cancer genetics research
Halbert CH, et al.
Am J Med Genet A 2007 Dec

Genetic susceptibility in pancreatic ductal adenocarcinoma
Lochan R, et al.
Br J Surg 2007 Dec

PTPN22: its role in SLE and autoimmunity
Chung SA & Criswell LA
Autoimmunity 2007 Dec;40(8):582-90

Fc receptor genes and the systemic lupus erythematosus diathesis
Brown EE, et al.
Autoimmunity 2007 Dec;40(8):567-81

Utah Family-Based Analysis: Past, Present and Future
Cannon Albright LA
Hum Hered 2007 Dec;65(4):209-20

Universal False Discovery Rate Estimation Methodology for Genome-Wide Association Studies
Forner K, et al.
Hum Hered 2007 Dec;65(4):183-94

Hereditary Breast Cancer: Part I. Diagnosing Hereditary Breast Cancer Syndromes
Lynch HT, et al.
Breast J 2007 Dec

Hereditary Breast Cancer: Part II. Management of Hereditary Breast Cancer: Implications of Molecular Genetics and Pathology
Silva E, et al.
Breast J 2007 Dec

Genetics of late-onset Alzheimer's disease: progress and prospect
Li Y & Grupe A
Pharmacogenomics 2007 Dec;8(12):1747-55

Endothelial nitric oxide synthase gene: prospects for treatment of heart disease
Cooke GE, et al.
Pharmacogenomics 2007 Dec;8(12):1723-34

Three lectures on case control genetic association analysis
Li W
Brief Bioinform 2007 Dec

Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases
Bustamante J, et al.
Curr Opin Immunol 2007 Dec

Genetic developments in autoimmune thyroid disease: an evolutionary process
Zeitlin AA, et al.
Clin Endocrinol (Oxf) 2007 Dec

Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H
de Cordoba SR & de Jorge EG
Clin Exp Immunol 2008 Jan;151(1):1-13

NPC-db, a Niemann-Pick type C disease gene variation database
Runz H, et al.
Hum Mutat 2007 Dec

Information Disclosure in Population-Based Research Involving Genetics: A Framework for the Practice of Ethics in Epidemiology
Kristman VL & Kreiger N
Ann Epidemiol 2007 Dec

Research highlights from the literature
Jordan J
Clin Auton Res 2007 Dec;17(6):331-3

 

 Genetic Testing

Assessment of the psychological effects of genetic screening for hereditary hemochromatosis
Elsass P, et al.
Ann Hematol 2007 Dec

Adipose tissue-specific PPARgamma deficiency increases resistance to oxidative stress
Luo W, et al.
Exp Gerontol 2007 Nov

Health-related quality of life in a racially diverse population screened for hemochromatosis: results from the Hemochromatosis and Iron Overload Screening (HEIRS) study
Wenzel LB, et al.
Genet Med 2007 Oct;9(10):705-12

Genetic screening for reproductive purposes at school: Is it a good strategy?
Frumkin A & Zlotogora J
Am J Med Genet A 2007 Dec

Molecular Diagnostics in Autosomal Dominant Polycystic Kidney Disease: Utility and Limitations
Zhao X, et al.
Clin J Am Soc Nephrol 2007 Dec

 

 Family History

Screening for dyslipidemia based on family history combined with obesity in children
Yan H, et al.
Beijing Da Xue Xue Bao 2007 Dec;39(6):591-4

Genetics: What Advice for Patients Who Present With a Family History of Melanoma?
Newton Bishop JA & Gruis NA
Semin Oncol 2007 Dec;34(6):452-9

Universal risk factors for multifactorial diseases : LifeLines: a three-generation population-based study
Stolk RP, et al.
Eur J Epidemiol 2007 Dec

Family history and the risk of oral and pharyngeal cancer
Garavello W, et al.
Int J Cancer 2007 Dec

Morbidity and mortality in first-degree relatives of C282Y homozygous probands with clinically detected haemochromatosis compared with the general population: the Hemochromatosis FAmily Study (HEFAS)
Jacobs EM, et al.
Neth J Med 2007 Dec;65(11):425-33

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending December 19, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: December 20, 2007 (archived document)
Content Source: CDC's Office of Public Health Genomics