Summaries & Associations of Study Results
TR-335 C.I. Acid Orange 3
Target Organs and Levels of Evidence
NTP Technical Report Number 335
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| C.I. ACID ORANGE 3 6373-74-6 |
07/14/87 | DYEING ACETATE, WOOL, NYLON, SILK, AND LEATHER; SHADING COMPONENT IN SOAPS AND WOOD STAINS. A DINITRODIPHENYLAMINE DERIVATIVE USED IN SEMIPERMANENT HAIR COLORING PRODUCTS. | Gavage R: 0,375,750 MG/KG MM: 0,125,250 MG/KG FM: 0,250,500 MG/KG/50 PER GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INFLAMMATION, SUPPURATIVE 7/50 37/50 44/50; PIGMENTATION 4/50 4/50 39/50; HYPERPLASIA, EPITHELIAL, PELVIC 0/50 6/50 13/50 | |||
| FR: CLEAR EVIDENCE | KIDNEY TRANSITIONAL CELL: CARCINOMA 0/50 0/50 6/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INFLAMMATION, SUPPURATIVE 0/50 10/50 45/50; PIGMENTATION 0/50 0/50 5/50; HYPERPLASIA, EPITHELIAL, PELVIC 0/50 2/50 13/50; NEPHROPATHY 23/50 45/50 48/50; NECROSIS, PAPILLA 0/50 0/50 10/50 | |||
| MM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INFLAMMATION, SUPPURATIVE 1/50 4/50 12/50; FIBROSIS 0/50 5/50 19/50; NECROSIS 0/50 0/50 7/50; DEGENERATION, PAPILLA 0/50 4/50 18/50; DILATATION, TUBULE 2/50 39/50 33/50 | |||
| FM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INFLAMMATION, SUPPURATIVE 7/50 7/50 22/50; FIBROSIS 4/50 9/50 31/50; NECROSIS 2/50 5/50 8/50; DEGENERATION, PAPILLA 0/50 3/50 19/50; DILATATION, TUBULE 2/50 35/50 42/50; NEPHROSIS 13/50 42/50 50/50; MINERALIZATION, TUBULE 3/50 15/50 22/50 | |||
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