page123
Modified release
Lopresor SR
c
(Recordati) A
Tablets
, m/r, yellow, f/c, metoprolol tartrate 200 mg,
net price 28-tab pack = £9.80.
Label:
8,
25
Dose
hypertension,
200 mg daily;
angina,
200–400 mg daily;
migraine prophylaxis,
200 mg daily
NADOLOL
Indications
see under Dose
Cautions
see under Propranolol Hydrochloride
Contra-indications
see under Propranolol Hydro-
chloride
Hepatic impairment
manufacturer advises caution
Renal impairment
increase dosage interval if eGFR
less than 50 mL/minute/1.73 m
2
Pregnancy
see notes above
Breast-feeding
see notes above
Side-effects
see under Propranolol Hydrochloride
Dose
. Hypertension,
initially 80 mg once daily,
increased in
increments of up to 80 mg at weekly intervals if
required;
max.
240 mg daily (higher doses rarely
necessary)
. Angina, initially 40 mg once daily, increased at weekly
intervals if required;
usual max.
160 mg daily (rarely
up to 240 mg may be required)
. Arrhythmias,
initially 40 mg once daily,
increased at
weekly intervals up to 160 mg if required;
reduce to
40 mg if bradycardia occurs
. Migraine prophylaxis,
initially 40 mg once daily,
increased in 40 mg increments at weekly intervals
according to response;
usual maintenance dose 80–
160 mg once daily
. Thyrotoxicosis (adjunct),
80–160 mg once daily
Corgard
c
(Sanofi-Aventis) A
Tablets
, blue, scored, nadolol 80 mg, net price 28-tab
pack = £5.00.
Label:
8
NEBIVOLOL
Indications
essential hypertension;
adjunct in stable
mild to moderate heart failure in patients over 70
years
Cautions
see under Propranolol Hydrochloride
Contra-indications
see under Propranolol Hydro-
chloride; also acute or decompensated heart failure
requiring intravenous inotropes
Hepatic impairment
no information available—man-
ufacturer advises avoid
Renal impairment
for
hypertension
,
initially 2.5 mg
once daily, increased to 5 mg once daily if required; for
heart failure
,
manufacturer advises avoid if serum
creatinine greater than 250 micromol/litre
Pregnancy
see notes above
Breast-feeding
see notes above
Side-effects
see under Propranolol Hydrochloride;
also oedema and depression
Dose
. Hypertension,
5 mg daily;
ELDERLY
initially 2.5 mg
daily,
increased if necessary to 5 mg daily
. Adjunct in heart failure (section 2.5.5),
initially
1.25 mg once daily,
then if tolerated increased at
intervals of 1–2 weeks to 2.5 mg once daily,
then to
5 mg once daily,
then to max. 10 mg once daily
Nebivolol
(Non-proprietary) A
Tablets
,
nebivolol (as hydrochloride) 5 mg,
net price
28-tab pack = £3.98.
Label:
8
Nebilet
c
(Menarini) A
Tablets
, scored, nebivolol (as hydrochloride) 5 mg, net
price 28-tab pack = £9.23.
Label:
8
Note
Also available as
Hypoloc
c
OXPRENOLOL HYDROCHLORIDE
Indications
see under Dose
Cautions
see under Propranolol Hydrochloride
Contra-indications
see under Propranolol Hydro-
chloride
Hepatic impairment
reduce dose
Pregnancy
see notes above
Breast-feeding
see notes above
Side-effects
see under Propranolol Hydrochloride
Dose
. Hypertension,
80–160 mg daily in 2–3 divided doses,
increased as required;
max.
320 mg daily
. Angina,
80–160 mg daily in 2–3 divided doses;
max.
320 mg daily
. Arrhythmias,
40–240 mg daily in 2–3 divided doses;
max.
240 mg daily
. Anxiety symptoms (short-term use),
40–80 mg daily
in 1–2 divided doses
Oxprenolol
(Non-proprietary) A
Tablets
,
coated, oxprenolol hydrochloride 20 mg,
net
price 56 = £1.86; 40 mg, 56 = £3.73; 80 mg, 56 = £6.20;
160 mg,
20 = £2.36.
Label:
8
Trasicor
c
(Amdipharm) A
Tablets
, f/c, oxprenolol hydrochloride 20 mg (contain
gluten), net price 56-tab pack = £1.86; 40 mg (contain
gluten),
56-tab pack = £3.73;
80 mg (yellow), 56-tab
pack = £6.20.
Label:
8
Modified release
Slow-Trasicor
c
(Amdipharm) A
Tablets
,
m/r,
f/c,
oxprenolol hydrochloride 160 mg,
net price 28-tab pack = £7.50.
Label:
8,
25
Dose
hypertension,
angina,
initially 160 mg once daily;
if
necessary may be increased to max.
320 mg daily
With diuretic
Trasidrex
c
(Goldshield) A
Tablets
,
red,
s/c,
co-prenozide 160/0.25 (oxprenolol
hydrochloride 160 mg (m/r),
cyclopenthiazide
250 micrograms),
net price 28-tab pack = £10.66.
Label:
8,
25
Dose
hypertension,
1 tablet daily,
increased if necessary to 2
daily as a single dose
PINDOLOL
Indications
see under Dose
Cautions
see under Propranolol Hydrochloride
Contra-indications
see under Propranolol Hydro-
chloride
Renal impairment
may adversely affect renal func-
tion in severe impairment—manufacturer advises
avoid
Pregnancy
see notes above
Breast-feeding
see notes above
Side-effects
see under Propranolol Hydrochloride
BNF 61
2.4 Beta-adrenoceptor blocking drugs
103
2
Cardiovascular system