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ACEBUTOLOL
Indications
see under Dose
Cautions
see under Propranolol Hydrochloride
Contra-indications
see under Propranolol Hydro-
chloride
Renal impairment
halve dose if eGFR 25–50 mL/
minute/1.73 m
2
;
use quarter dose if eGFR less than
25 mL/minute/1.73 m
2
; do not administer more than
once daily
Pregnancy
see notes above
Breast-feeding
see notes above
Side-effects
see under Propranolol Hydrochloride
Dose
. Hypertension,
initially 400 mg once daily
or
200 mg
twice daily,
increased after 2 weeks to 400 mg twice
daily if necessary
. Angina,
initially 400 mg once daily
or
200 mg twice
daily; 300 mg 3 times daily in severe angina;
up to
1.2 g daily has been used
. Arrhythmias,
0.4–1.2 g daily in 2–3 divided doses
Sectral
c
(Sanofi-Aventis) A
Capsules
,
acebutolol (as hydrochloride) 100 mg
(buff/white), net price 84-cap pack = £14.97;
200 mg
(buff/pink), 56-cap pack = £19.18.
Label:
8
Tablets
,
f/c,
acebutolol 400 mg (as hydrochloride),
net price 28-tab pack = £18.62.
Label:
8
ATENOLOL
Indications
see under Dose
Cautions
see under Propranolol Hydrochloride
Contra-indications
see under Propranolol Hydro-
chloride
Renal impairment
max.
50 mg daily (10 mg on alter-
nate days
intravenously
) if eGFR 15–35 mL/minute/
1.73 m
2
; max. 25 mg daily or 50 mg on alternate days
(10 mg every 4 days
intravenously
) if eGFR less than
15 mL/minute/1.73 m
2
Pregnancy
see notes above
Breast-feeding
see notes above
Side-effects
see under Propranolol Hydrochloride
Dose
. By mouth, hypertension, 25–50 mg daily (higher doses
rarely necessary)
Angina,
100 mg daily in 1 or 2 doses
Arrhythmias,
50–100 mg daily
Migraine prophylaxis [unlicensed], 50–200 mg daily in
divided doses
.
By intravenous injection, arrhythmias, 2.5 mg at a rate
of 1 mg/minute,
repeated at 5-minute intervals to a
max.
of 10 mg
Note
Excessive bradycardia can be countered with intra-
venous injection of atropine sulphate 0.6–2.4 mg in divided
doses of 600 micrograms; for overdosage see Emergency
Treatment of Poisoning,
p.
37
. By intravenous infusion,
arrhythmias,
150 micr-
ograms/kg over 20 minutes, repeated every 12 hours
if required
Early intervention within 12 hours of myocardial
infarction (section 2.10.1),
by intravenous injection
over 5 minutes,
5 mg,
then by mouth,
50 mg after 15
minutes,
50 mg after 12 hours,
then 100 mg daily
Atenolol
(Non-proprietary) A
Tablets
, atenolol 25 mg, net price 28-tab pack = 83p;
50 mg, 28-tab pack = 86p; 100 mg, 28-tab pack = 91p.
Label:
8
Tenormin
c
(AstraZeneca) A
‘25’ tablets
, f/c, atenolol 25 mg, net price 28-tab pack
= £1.16.
Label:
8
LS tablets
,
orange,
f/c,
scored,
atenolol 50 mg,
net
price 28-tab pack = £2.04.
Label:
8
Tablets
,
orange,
f/c,
scored,
atenolol 100 mg,
net
price 28-tab pack = £3.46.
Label:
8
Syrup
,
sugar-free,
atenolol 25 mg/5 mL,
net price
300 mL = £8.55.
Label:
8
Injection
, atenolol 500 micrograms/mL, net price 10-
mL amp = 96p (hosp.
only)
With diuretic
Co-tenidone
(Non-proprietary) A
Tablets
,
co-tenidone 50/12.5 (atenolol 50 mg,
chlor-
talidone 12.5 mg), net price 28-tab pack = £1.77;
co-
tenidone 100/25 (atenolol 100 mg,
chlortalidone
25 mg),
28-tab pack = £1.57.
Label:
8
Dose
hypertension,
1 tablet daily (but see also under Dose
above)
Kalten
c
(BPC 100) A
Capsules
,
red/ivory,
atenolol 50 mg,
co-amilozide
2.5/25 (anhydrous amiloride hydrochloride 2.5 mg,
hydrochlorothiazide 25 mg),
net price 28-cap pack =
£12.17.
Label:
8
Dose
hypertension,
1 capsule daily
Tenoret 50
c
(AstraZeneca) A
Tablets
,
brown,
f/c,
co-tenidone 50/12.5 (atenolol
50 mg, chlortalidone 12.5 mg), net price 28-tab pack =
£1.15.
Label:
8
Dose
hypertension,
1 tablet daily
Tenoretic
c
(AstraZeneca) A
Tablets
,
brown,
f/c,
co-tenidone 100/25 (atenolol
100 mg, chlortalidone 25 mg), net price 28-tab pack =
£1.25.
Label:
8
Dose
hypertension,
1 tablet daily (but see also under Dose
above)
With calcium-channel blocker
Note
Only indicated when calcium-channel
blocker or beta-
blocker alone proves inadequate. For prescribing information
on nifedipine see section 2.6.2
Beta-Adalat
c
(Bayer Schering) A
Capsules
,
reddish-brown, atenolol 50 mg,
nifedipine
20 mg (m/r), net price 28-cap pack = £9.00. Label: 8,
25
Dose
hypertension,
1 capsule daily,
increased if necessary to
twice daily;
ELDERLY,
1 daily
Angina,
1 capsule twice daily
Tenif
c
(AstraZeneca) A
Capsules
,
reddish-brown, atenolol 50 mg,
nifedipine
20 mg (m/r), net price 28-cap pack = £10.63. Label: 8,
25
Dose
hypertension,
1 capsule daily,
increased if necessary to
twice daily;
ELDERLY,
1 daily
Angina,
1 capsule twice daily
100
2.4 Beta-adrenoceptor blocking drugs
BNF 61
2
Cardiovascular system